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Federica Morani
Federica Morani
Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences
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Rossella Titone
Rossella Titone
Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences
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Loredana Pagano
Loredana Pagano
Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences
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Alessandra Galetto
Alessandra Galetto
Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences
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Oscar Alabiso
Oscar Alabiso
Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences
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Gianluca Aimaretti
Gianluca Aimaretti
Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences
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Ciro Isidoro
Ciro Isidoro
Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences
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, we examine the genetic and epigenetic links between autophagy and thyroid carcinogenesis. A better understanding of such mechanistic connections could help to identify new targets for a more accurate diagnostic, prognostic, and therapeutic management
Maria Grazia Vizioli
Maria Grazia Vizioli
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Patricia A Possik
Patricia A Possik
Molecular Mechanisms Unit, Division of Molecular Genetics, Department of Pathology, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation - Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy
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Eva Tarantino
Eva Tarantino
Molecular Mechanisms Unit, Division of Molecular Genetics, Department of Pathology, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation - Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy
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Katrin Meissl
Katrin Meissl
Molecular Mechanisms Unit, Division of Molecular Genetics, Department of Pathology, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation - Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy
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Maria Grazia Borrello
Maria Grazia Borrello
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Claudia Miranda
Claudia Miranda
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Maria Chiara Anania
Maria Chiara Anania
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Sonia Pagliardini
Sonia Pagliardini
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Ettore Seregni
Ettore Seregni
Molecular Mechanisms Unit, Division of Molecular Genetics, Department of Pathology, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation - Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy
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Marco A Pierotti
Marco A Pierotti
Molecular Mechanisms Unit, Division of Molecular Genetics, Department of Pathology, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation - Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy
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Silvana Pilotti
Silvana Pilotti
Molecular Mechanisms Unit, Division of Molecular Genetics, Department of Pathology, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation - Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy
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Daniel S Peeper
Daniel S Peeper
Molecular Mechanisms Unit, Division of Molecular Genetics, Department of Pathology, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation - Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy
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Angela Greco
Angela Greco
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increasing evidence of OIS involvement in human cancer suggests the possibility of new therapeutic approaches based on the functional restoration of OIS in tumour cells. In this study, we investigate the occurrence of OIS in thyroid carcinogenesis with in
Stefan Karger
Stefan Karger
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Carl Weidinger
Carl Weidinger
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Kerstin Krause
Kerstin Krause
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Sien-Yi Sheu
Sien-Yi Sheu
Division of Endocrinology and Diabetes, Institute of Pathology and Neuropathology, Institute of Pathology, Department of Surgery, Department of Internal Medicine, University of Leipzig, Ph.-Rosenthal-Street 27, 04103 Leipzig, Germany
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Thomas Aigner
Thomas Aigner
Division of Endocrinology and Diabetes, Institute of Pathology and Neuropathology, Institute of Pathology, Department of Surgery, Department of Internal Medicine, University of Leipzig, Ph.-Rosenthal-Street 27, 04103 Leipzig, Germany
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Oliver Gimm
Oliver Gimm
Division of Endocrinology and Diabetes, Institute of Pathology and Neuropathology, Institute of Pathology, Department of Surgery, Department of Internal Medicine, University of Leipzig, Ph.-Rosenthal-Street 27, 04103 Leipzig, Germany
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Kurt-Werner Schmid
Kurt-Werner Schmid
Division of Endocrinology and Diabetes, Institute of Pathology and Neuropathology, Institute of Pathology, Department of Surgery, Department of Internal Medicine, University of Leipzig, Ph.-Rosenthal-Street 27, 04103 Leipzig, Germany
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Henning Dralle
Henning Dralle
Division of Endocrinology and Diabetes, Institute of Pathology and Neuropathology, Institute of Pathology, Department of Surgery, Department of Internal Medicine, University of Leipzig, Ph.-Rosenthal-Street 27, 04103 Leipzig, Germany
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Dagmar Fuhrer
Dagmar Fuhrer
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emerged to play a fundamental role in thyroid carcinogenesis ( Paes & Ringel 2008 ). Since we observed an inhibitory impact of the PI3K/Akt pathway on FOXO3a activity in vitro , we were interested to know whether this regulatory principle might also apply
Monica Fedele
Monica Fedele
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Dario Palmieri
Dario Palmieri
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Gennaro Chiappetta
Gennaro Chiappetta
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Rosa Pasquinelli
Rosa Pasquinelli
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Ivana De Martino
Ivana De Martino
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Claudio Arra
Claudio Arra
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Giuseppe Palma
Giuseppe Palma
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Teresa Valentino
Teresa Valentino
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Giovanna M Pierantoni
Giovanna M Pierantoni
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Giuseppe Viglietto
Giuseppe Viglietto
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Jay L Rothstein
Jay L Rothstein
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Massimo Santoro
Massimo Santoro
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Alfredo Fusco
Alfredo Fusco
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto dei Tumori di Napoli Fondazione ‘G. Pascale’, Dipartimento di Medicina Sperimentale e Clinica, Inflammation Research, NOGEC (Naples Oncogenomic Center)-Ceinge, Via S. Pansini 5, 80131 Naples, Italy
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data show increased miR221 and 222 levels in PTCs that correlate with low levels of p27 ( Visone et al . 2007 ). However, a causal link between p27 impairment and thyroid carcinogenesis has not been established yet. The aim of the present work was to
Lucas Leite Cunha
Lucas Leite Cunha
Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo, Brazil
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Marjory Alana Marcello
Marjory Alana Marcello
Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo, Brazil
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Laura Sterian Ward
Laura Sterian Ward
Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo, Brazil
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microenvironment is established in thyroid tumors and what is its influence on the outcome of patients with DTC. Principles of thyroid carcinogenesis Although ∼50–67% of the population will eventually present a thyroid nodule during their lives ( Mazzaferri 2006
Xuguang Zhu
Xuguang Zhu
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Dong Wook Kim
Dong Wook Kim
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Li Zhao
Li Zhao
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Mark C Willingham
Mark C Willingham
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Sheue-yann Cheng
Sheue-yann Cheng
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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human thyroid cancer with a pathological progression from hyperplasia to capsular invasion, vascular invasion, and eventually metastasis ( Suzuki et al . 2002 ). Extensive molecular analyses of altered signaling pathways during thyroid carcinogenesis
Jeong Won Park
Jeong Won Park
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 5128, Bethesda, Maryland 20892-6264, USA
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Cho Rong Han
Cho Rong Han
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 5128, Bethesda, Maryland 20892-6264, USA
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Li Zhao
Li Zhao
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 5128, Bethesda, Maryland 20892-6264, USA
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Mark C Willingham
Mark C Willingham
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 5128, Bethesda, Maryland 20892-6264, USA
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Sheue-yann Cheng
Sheue-yann Cheng
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 5128, Bethesda, Maryland 20892-6264, USA
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increased risk thyroid cancer, the molecular mechanisms by which obesity increase the risk of thyroid cancer progression are poorly understood. Because it would be difficult to study how obesity could affect thyroid carcinogenesis in patients at the
Elena Stauffer
Elena Stauffer
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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Peter Weber
Peter Weber
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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Theresa Heider
Theresa Heider
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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Claudia Dalke
Claudia Dalke
Helmholtz Zentrum München – German Research Center for Environmental Health, Institute of Metabolism and Cell Death, Neuherberg, Germany
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Andreas Blutke
Andreas Blutke
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Analytical Pathology, Neuherberg, Germany
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Axel Walch
Axel Walch
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Analytical Pathology, Neuherberg, Germany
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Gerald Burgstaller
Gerald Burgstaller
Helmholtz Zentrum München – Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany
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Nikko Brix
Nikko Brix
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
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Kirsten Lauber
Kirsten Lauber
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Horst Zitzelsberger
Horst Zitzelsberger
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Kristian Unger
Kristian Unger
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Martin Selmansberger
Martin Selmansberger
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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according to a multi-step model ( Vogelstein & Kinzler 1993 , Kondo et al. 2006 ). Those alterations, that consequently stimulate effectors of the MAPK signaling pathway or PI3K/AKT signaling pathway, play a central role in thyroid carcinogenesis
Fiorenza Gianì
Fiorenza Gianì
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Giuseppe Pandini
Giuseppe Pandini
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Nunzio Massimo Scalisi
Nunzio Massimo Scalisi
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Paolo Vigneri
Paolo Vigneri
Medical Oncology and Center of Experimental Oncology and Hematology, Department of Clinical and Experimental Medicine, University of Catania, A.O.U Policlinico Vittorio Emanuele, Catania, Italy
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Carmine Fazzari
Carmine Fazzari
Humanitas, Catania Oncology Center, Catania, Italy
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Pasqualino Malandrino
Pasqualino Malandrino
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Marco Russo
Marco Russo
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Romilda Masucci
Romilda Masucci
Surgical Oncology, Garibaldi-Nesima Medical Center, Catania, Italy
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Antonino Belfiore
Antonino Belfiore
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Gwabriella Pellegriti
Gwabriella Pellegriti
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Riccardo Vigneri
Riccardo Vigneri
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
IC Crystallography Institute, National Research Council, CNR, Catania, Italy
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IC Crystallography Institute, National Research Council, CNR, Catania, Italy
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) Nakashima M Suzuki K Meirmanov S Naruke Y Matsuu‐Matsuyama M Shichijo K Saenko V Kondo H Hayashi T Ito M , et al . 2008 Foci formation of P53‐binding protein 1 in thyroid tumors: activation of genomic instability during thyroid
Pei-Pei Xu
Pei-Pei Xu
Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Su Zeng
Su Zeng
Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Xiao-Tian Xia
Xiao-Tian Xia
Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Zi-Heng Ye
Zi-Heng Ye
Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Mei-Fang Li
Mei-Fang Li
Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Ming-Yun Chen
Ming-Yun Chen
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai, China
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Tian Xia
Tian Xia
CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
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Jing-Jing Xu
Jing-Jing Xu
Department of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
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Qiong Jiao
Qiong Jiao
Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Liang Liu
Liang Liu
Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Lian-Xi Li
Lian-Xi Li
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai, China
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Ming-Gao Guo
Ming-Gao Guo
Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Our aims were to uncover the role of FAM172A (Family with sequence similarity 172 member A) in the pathogenesis of follicular thyroid carcinoma (FTC) and to evaluate its value in the differential diagnosis between malignant and benign thyroid follicular lesions. FAM172A expression was evaluated by q-PCR, immunoblotting and immunohistochemistry (IHC). The ability of proliferation, migration and invasion of cells were assessed by Cell Counting Kit-8 assay (CCK8), clone-formation and Transwell assays. Nude mouse tumorigenicity assays were used to investigate the role of FAM172A in the pathogenesis of FTC in vivo. The value of FAM172A in the differential diagnosis for FTC was assessed using 120 formalin-fixed paraffin-embedded (FFPE) tissues after the operation and 81 fine-needle aspiration biopsy (FNAB) samples before the operation. FAM172A was highly expressed in FTC tissues and FTC cell lines. Downregulation of FAM172A inhibited the proliferation, invasion and migration of FTC cells through Erk1/2 and JNK pathways. Subcutaneous tumorigenesis in nude mice showed that knockdown of FAM172A inhibited tumor growth and progression in vivo. The FAM172A IHC scores of 3.5 had 92% sensitivity and 63% specificity to separate FTC from benign/borderline thyroid follicular lesions, and 92% sensitivity and 80% specificity to discriminate FTC from benign thyroid follicular lesions in postoperative FFPE samples. The corresponding values were 75 and 78%, and 75 and 89% in preoperative FNA samples, respectively. FAM172A plays an important role in the pathogenesis of FTC through Erk1/2 and JNK pathways. FAM172A may be a potential marker for the preoperative diagnosis of FTC based on the IHC results of thyroid FNAB samples.
