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Tae-Hwan Kim Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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Mi Yeon Lee Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Sung Min Jin Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sang Hyuk Lee Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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The impact of serum thyroid hormone levels on thyroid cancer risk is unclear. Some studies reported that elevated thyroid-stimulating hormone (TSH) is associated with higher risk for incidence of thyroid cancer, but other studies reported no relationship. We conducted a large cohort study in 164,596 South Korean men and women who were free of thyroid cancer at baseline and underwent health examination with hormone levels of thyroid function. A parametric proportional hazard model was used to evaluate the adjusted hazard ratio (HR) and 95% CI. During 2,277,749.78 person-years of follow-up, 1280 incident thyroid cancers were identified (men = 593, women = 687). Among men, the multivariable-adjusted HR (95% CI) for thyroid cancer comparing low levels of TSH with normal levels of TSH was 2.95 (1.67–5.23), whereas the corresponding HR (95% CI) in women was 1.5 (0.88–2.55). High levels of free T4 and free T3 were also associated with incident thyroid cancer in both men and women. In clinical implication, overt hyperthyroidism is associated with thyroid cancer in both men and women. Within the euthyroid range, the highest tertile of TSH was associated with a lower risk of thyroid cancer than the lowest TSH tertile and the highest FT4 tertile was associated with a higher risk of thyroid cancer than the lowest FT4 tertile in both men and women. Our finding indicates that low levels of TSH and high levels of FT4, even within the normal range, were associated with an increased risk of incident thyroid cancer.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0094
Volume/Issue:
Volume 29: Issue 12
Restricted access
Tommaso Porcelli Department of Public Health, University of Naples ‘Federico II’, Naples, Italy

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Raffaele Ambrosio Department of Public Health, University of Naples ‘Federico II’, Naples, Italy

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Maria Angela De Stefano Department of Public Health, University of Naples ‘Federico II’, Naples, Italy

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Cristina Luongo Department of Clinical Medicine and Surgery, University of Naples ‘Federico II’, Naples, Italy

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Daniela Terracciano Department of Translational Medical Sciences, University of Naples ‘Federico II’, Naples, Italy

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Caterina Miro Department of Clinical Medicine and Surgery, University of Naples ‘Federico II’, Naples, Italy

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Monica Dentice Department of Clinical Medicine and Surgery, University of Naples ‘Federico II’, Naples, Italy

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Martin Schlumberger Department of Endocrine Oncology, Gustave Roussy and University Paris-Saclay, Villejuif, France

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Domenico Salvatore Department of Public Health, University of Naples ‘Federico II’, Naples, Italy
CEINGE Biotecnologie Avanzate Scarl, Naples, Italy

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Treatment with tyrosine kinase inhibitors (TKIs) has been associated with alterations in circulating thyroid hormone levels, possibly related to perturbations in peripheral thyroid hormone metabolism. In this study, we evaluated the effect of the multi-kinase inhibitor vandetanib on the expression of the three deiodinase selenoenzymes, responsible for the thyroid hormone activation (type 1 and type 2 deiodinases) or for its inactivation (type 3 deiodinase). Here, we show that the multi-kinase inhibitor vandetanib determines a strong cell-specific downregulation of type 2 deiodinase (D2) expression and a significant reduction in D2 enzymatic activity. This occurs in the diffused population of fibro/adipogenic progenitors, which reside in different tissues – including the muscles – and normally express D2. Given the widespread diffusion of mesenchymal cells within the body, our results may explain at least partially the alterations in thyroid hormone levels that occur in vandetanib-treated patients. Our findings represent a step forward into the understanding of the mechanisms by which TKIs induce hypothyroidism and identify a resident cell population in which such an effect takes place.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0269
Volume/Issue:
Volume 30: Issue 5
Restricted access
Briseis Aschebrook-Kilfoy Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Gila Neta Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Alina V Brenner Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Amy Hutchinson Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Ruth M Pfeiffer Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Erich M Sturgis Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Li Xu Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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William Wheeler Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Michele M Doody Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Stephen J Chanock Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Alice J Sigurdson Occupational and Environmental Epidemiology Branch, Department of Health Studies, Radiation Epidemiology Branch, Core Genotype Facility, Biostatistics Branch, Department of Head and Neck Surgery, Information Management Services, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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NAT2 ( Hernández et al . 2008 , Lemos et al . 2008 , Guilhen et al . 2009 ). Thus, there is some evidence of associations for thyroid cancer with polymorphisms in genes related to thyroid hormone metabolism and detoxification enzymes, but the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0372
Volume/Issue:
Volume 19: Issue 3
Free access
Loredana Bianchi
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Luigi Rossi
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Federica Tomao Oncology Unit - ICOT, Department of Gynecology and Urology, Department of Medico-Surgical Sciences and Biotechnologies, University of Rome ‘Sapienza’, Latina, Italy

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Anselmo Papa
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Federica Zoratto
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Silverio Tomao
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autoimmunological background. Thyroid hormone metabolism Abdulrahman hypothesized the influence of sorafenib on iodothyronine deiodinase (D1, D2, and D3) activity, resulting in enhanced T 4 and T 3 metabolism that may contribute to hypothyroidism during sorafenib

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0201
Volume/Issue:
Volume 20: Issue 5
Free access
Monia Zidane INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Radiation Epidemiology Group, Villejuif, France
Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France

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Jean-Baptiste Cazier Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, UK

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Sylvie Chevillard CEA, Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, iRCM, SREIT, Laboratoire de Cancérologie Expérimentale (LCE), Université Paris-Saclay, Fontenay-aux-Roses, France

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Catherine Ory CEA, Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, iRCM, SREIT, Laboratoire de Cancérologie Expérimentale (LCE), Université Paris-Saclay, Fontenay-aux-Roses, France

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Martin Schlumberger Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France
UMR 8200 CNRS, Villejuif, France

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Corinne Dupuy Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France
UMR 8200 CNRS, Villejuif, France

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Jean-François Deleuze Centre National de Recherche en Génomique Humaine, CEA, Evry, France

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Anne Boland Centre National de Recherche en Génomique Humaine, CEA, Evry, France

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Nadia Haddy INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Radiation Epidemiology Group, Villejuif, France
Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France

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Fabienne Lesueur Institut Curie, Paris, France
PSL Research University, Paris, France
INSERM, U900, Paris, France
Mines Paris Tech, Fontainebleau, France

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Florent de Vathaire INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Radiation Epidemiology Group, Villejuif, France
Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France

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in LIG1 , one was in ALKBH3 and one was in ERCC2 . Other SNPs associated to radiation-related DTC are in or near genes involved in thyroid hormone metabolism such as FOXE1 , TSHR and NKX2-1. The latter are associated with both sporadic and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0321
Volume/Issue:
Volume 26: Issue 10
Free access
Helena Andrea Sterle Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Ximena Hildebrandt Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Matías Valenzuela Álvarez Remodeling Processes and Cellular Niches Laboratory, Institute of Translational Medicine and Biomedical Engineering (IMTIB), National Scientific and Technical Research Council (CONICET), Italian Hospital of Buenos Aires and the University Institute of the Italian Hospital (IUHI), Buenos Aires, Argentina

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María Alejandra Paulazo Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Luciana Mariel Gutierrez Remodeling Processes and Cellular Niches Laboratory, Institute of Translational Medicine and Biomedical Engineering (IMTIB), National Scientific and Technical Research Council (CONICET), Italian Hospital of Buenos Aires and the University Institute of the Italian Hospital (IUHI), Buenos Aires, Argentina

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Alicia Juana Klecha Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Florencia Cayrol Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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María Celeste Díaz Flaqué Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Cinthia Rosemblit Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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María Laura Barreiro Arcos Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Lucas Colombo Immunobiology Department, Investigation Area, Institute of Oncology Angel H. Roffo, University of Buenos Aires (UBA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Marcela Fabiana Bolontrade Remodeling Processes and Cellular Niches Laboratory, Institute of Translational Medicine and Biomedical Engineering (IMTIB), National Scientific and Technical Research Council (CONICET), Italian Hospital of Buenos Aires and the University Institute of the Italian Hospital (IUHI), Buenos Aires, Argentina

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Vanina Araceli Medina Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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Graciela Alicia Cremaschi Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

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postmenopausal women . Breast Cancer Research 12 R33. ( https://doi.org/10.1186/bcr2587 ) van der Spek AH Fliers E Boelen A 2017 The classic pathways of thyroid hormone metabolism . Molecular and Cellular Endocrinology 458 29 – 38 . ( https

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0277
Volume/Issue:
Volume 28: Issue 7
Restricted access
Maya B Lodish Section on Endocrinology Genetics, Pediatric Endocrinology Inter-Institute Training Program, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Section on Endocrinology Genetics, Pediatric Endocrinology Inter-Institute Training Program, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

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Constantine A Stratakis Section on Endocrinology Genetics, Pediatric Endocrinology Inter-Institute Training Program, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Section on Endocrinology Genetics, Pediatric Endocrinology Inter-Institute Training Program, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

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TKIs has raised the awareness of adverse affects on thyroid hormone function and/or thyroid hormone metabolism, as outlined in Table 2 . As a result of these studies, it is now recommended that all patients starting therapy with TKIs have their thyroid

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0082
Volume/Issue:
Volume 17: Issue 3
Free access
Maria Angela De Stefano Department of Public Health, University of Naples “Federico II”, Naples, Italy

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Tommaso Porcelli Department of Public Health, University of Naples “Federico II”, Naples, Italy

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Martin Schlumberger Department of Endocrine Oncology, Gustave Roussy and University Paris-Saclay, Villejuif, France

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Domenico Salvatore Department of Public Health, University of Naples “Federico II”, Naples, Italy
CEINGE Biotecnologie Avanzate Scarl, Naples, Italy

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Battiprolu PK Nguyen A , 2020 FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth . Nature Communications 11 2551. ( https://doi.org/10.1038/s41467-020-16345-y ) 32439985 Field JB Ealey PA Marshall

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-23-0015
Volume/Issue:
Volume 30: Issue 5
Open access
T M A Kerkhofs Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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M H T Ettaieb Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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I G C Hermsen Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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H R Haak Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands
Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands
Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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effect on the pituitary gland or induction of thyroid hormone metabolism ( Zatelli et al . 2010 ). Based on clinical experience, treatment with thyroxine supplementation restores euthyroidism. In men with signs of hypogonadism, assessment of testosterone

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0318
Volume/Issue:
Volume 22: Issue 6
Free access
Kathrin A Schmohl Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany

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Peter J Nelson Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany

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Christine Spitzweg Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany

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.11.7.1376 ) 10.1200/JCO.1993.11.7.1376 Wu SY Green WL Huang WS Hays MT Chopra IJ 2005 Alternate pathways of thyroid hormone metabolism . Thyroid 15 943 – 958 . ( https://doi.org/10.1089/thy.2005.15.943 ) 10.1089/thy.2005.15.943 16131336 Xie TX Xia Z

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0058
Volume/Issue:
Volume 26: Issue 6
Free access