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Dolly Thomas
Dolly Thomas
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
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Susan Friedman
Susan Friedman
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
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Reigh-Yi Lin
Reigh-Yi Lin
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
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Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
Department of Medicine, Department of Molecular, The Leon D. Black Family Stem Cell Institute, Mount Sinai School of Medicine, Box 1055, One Gustave L. Levy Place, New York, New York 10029, USA
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thyroid stem cells has been largely unstudied. This discrepancy may be due to the availability of an effective, economical, standardized, and well-tolerated hormone replacement therapy for hypothyroidism. The recent identification and characterization of
Fiorenza Gianì
Fiorenza Gianì
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Giuseppe Pandini
Giuseppe Pandini
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Nunzio Massimo Scalisi
Nunzio Massimo Scalisi
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Paolo Vigneri
Paolo Vigneri
Medical Oncology and Center of Experimental Oncology and Hematology, Department of Clinical and Experimental Medicine, University of Catania, A.O.U Policlinico Vittorio Emanuele, Catania, Italy
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Carmine Fazzari
Carmine Fazzari
Humanitas, Catania Oncology Center, Catania, Italy
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Pasqualino Malandrino
Pasqualino Malandrino
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Marco Russo
Marco Russo
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Romilda Masucci
Romilda Masucci
Surgical Oncology, Garibaldi-Nesima Medical Center, Catania, Italy
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Antonino Belfiore
Antonino Belfiore
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Gwabriella Pellegriti
Gwabriella Pellegriti
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
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Riccardo Vigneri
Riccardo Vigneri
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
IC Crystallography Institute, National Research Council, CNR, Catania, Italy
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IC Crystallography Institute, National Research Council, CNR, Catania, Italy
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Thyroid cancer incidence is increased in volcanic areas where environment pollution biocontaminates residents. Tungsten (W) is the most increased heavy metal in drinking water of Mount Etna volcanic area where it exceeds the normal range in the urine of 27% inhabitants. The possible connection between increased tungsten and thyroid cancer has never been studied. We investigated in vitro the effect tungsten on both human thyrocytes in primary culture, thyrospheres (aggregates of stem/precursor thyroid cells) and thyrocytes differentiated from tungsten-exposed thyrospheres. Chronic exposure to low-dose (nanomolar range, as in the urines of volcanic area residents) soluble tungsten had major biological effects on thyroid stem/precursor cells, promoting growth with a biphasic (hormetic) dose-response and reducing apoptosis. No such effects were observed in mature thyrocytes. In addition, tungsten-exposed thyrospheres had abnormal expression of genes commonly altered also in thyroid cancer and increased activation of the DNA-repair proteins H2AX and 53BP1. Moreover, exposure to tungsten decreased thyrosphere differentiation, as indicated by the reduced expression of thyroid-specific genes in derived thyrocytes that also showed preneoplastic changes such as increased anchorage-independent growth, clonogenic growth and migration capacity. The mechanism of action of tungsten on thyroid stem/precursor cells is unclear but involves membrane G-proteins and activation of the ERK signaling pathway. These data indicate that chronic exposure to slightly increased tungsten, harmless for mature thyrocytes, importantly affects the biology of stem/precursor thyroid cells and of their progeny, inducing characteristics of preneoplastic transformation.
John E Phay
John E Phay
Division of Surgical Oncology, Division of Endocrinology, Department of Surgery
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Matthew D Ringel
Matthew D Ringel
Division of Surgical Oncology, Division of Endocrinology, Department of Surgery
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response to injury and therefore can be either quiescent or cycling, depending on the need of the organ. Adult thyroid stem cells have long been posited ( Dumont et al . 1992 ), but human thyroid follicular cells are estimated to have a turnover rate of ∼8
Caterina Tiozzo
Caterina Tiozzo
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Soula Danopoulos
Soula Danopoulos
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Maria Lavarreda-Pearce
Maria Lavarreda-Pearce
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Sheryl Baptista
Sheryl Baptista
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Radka Varimezova
Radka Varimezova
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Denise Al Alam
Denise Al Alam
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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David Warburton
David Warburton
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Rehan Virender
Rehan Virender
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Stijn De Langhe
Stijn De Langhe
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Antonio Di Cristofano
Antonio Di Cristofano
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Saverio Bellusci
Saverio Bellusci
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Parviz Minoo
Parviz Minoo
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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Developmental Biology Program, Department of Pediatrics, Department of Pediatrics, Department of Pediatrics, Division of Cell Biology, Department of Developmental and Molecular Biology, Department of Internal Medicine II, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
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homeostasis is thought to be maintained by a distinct pool of stem cells present in the adult thyroid gland. At least two types of thyroid stem cells have been described in the literature: the progenitor of follicular cells and the progenitor of C cells
Michael Derwahl
Michael Derwahl
Department of Medicine, St Hedwig Hospital and Charite, University Medicine Berlin, Grosse Hamburger Straße 5‐11, 10115 Berlin, Germany
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Diana Nicula
Diana Nicula
Department of Medicine, St Hedwig Hospital and Charite, University Medicine Berlin, Grosse Hamburger Straße 5‐11, 10115 Berlin, Germany
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addition, in thyroid cancer, the PI3K/Akt pathway may also be activated by mutational inactivation of PTEN , a tumor-suppressor gene, or decreased/ absent expression of its mRNA or protein ( Bruni et al . 2000 ). Estrogen and thyroid stem cells There is
Zhenying Guo
Zhenying Guo
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China
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Heather Hardin
Heather Hardin
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China
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Ricardo V Lloyd
Ricardo V Lloyd
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China
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is combined with conventional therapy it may be possible to eradicate even highly lethal cancers such as anaplastic thyroid carcinomas. Thyroid stem cells and CSCs identification The precise tissue microenvironment of thyroid CSCs remains unknown
Dang Vu-Phan
Dang Vu-Phan
Cellular and Molecular Biology Graduate Program, Division of Metabolism, Department of Comparative Medicine, Division of Hematology and Oncology, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
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Vladimir Grachtchouk
Vladimir Grachtchouk
Cellular and Molecular Biology Graduate Program, Division of Metabolism, Department of Comparative Medicine, Division of Hematology and Oncology, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
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Jingcheng Yu
Jingcheng Yu
Cellular and Molecular Biology Graduate Program, Division of Metabolism, Department of Comparative Medicine, Division of Hematology and Oncology, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
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Lesley A Colby
Lesley A Colby
Cellular and Molecular Biology Graduate Program, Division of Metabolism, Department of Comparative Medicine, Division of Hematology and Oncology, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
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Max S Wicha
Max S Wicha
Cellular and Molecular Biology Graduate Program, Division of Metabolism, Department of Comparative Medicine, Division of Hematology and Oncology, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
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Ronald J Koenig
Ronald J Koenig
Cellular and Molecular Biology Graduate Program, Division of Metabolism, Department of Comparative Medicine, Division of Hematology and Oncology, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
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subpopulation of thyroid cancer cells are promising tools for future use in the study of thyroid stem cells and cancer. The mechanism of Wnt/TCF pathway activation by PPFP is unclear, except that it requires the PPARG DBD within PPFP. Activation of this pathway
Elena Stauffer
Elena Stauffer
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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Peter Weber
Peter Weber
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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Theresa Heider
Theresa Heider
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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Claudia Dalke
Claudia Dalke
Helmholtz Zentrum München – German Research Center for Environmental Health, Institute of Metabolism and Cell Death, Neuherberg, Germany
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Andreas Blutke
Andreas Blutke
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Analytical Pathology, Neuherberg, Germany
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Axel Walch
Axel Walch
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Analytical Pathology, Neuherberg, Germany
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Gerald Burgstaller
Gerald Burgstaller
Helmholtz Zentrum München – Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany
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Nikko Brix
Nikko Brix
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
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Kirsten Lauber
Kirsten Lauber
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Horst Zitzelsberger
Horst Zitzelsberger
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Kristian Unger
Kristian Unger
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Neuherberg, Germany
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Martin Selmansberger
Martin Selmansberger
Helmholtz Zentrum München – German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Neuherberg, Germany
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Ukraine (1998–2000) . American Journal of Epidemiology 167 305 – 312 . ( https://doi.org/10.1093/aje/kwm301 ) Zane M Scavo E Catalano V Bonanno M Todaro M De Maria R Stassi G 2016 Normal vs cancer thyroid stem cells: the road to
Amruta Ashtekar
Amruta Ashtekar
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA
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Danielle Huk
Danielle Huk
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA
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Alexa Magner
Alexa Magner
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA
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Krista La Perle
Krista La Perle
Department of Veterinary Biosciences and Comparative Pathology & Mouse Phenotyping Shared Resource, The Ohio State University, Columbus, Ohio, USA
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Xiaoli Zhang
Xiaoli Zhang
Department of Biostatistics, The Ohio State University, Columbus, Ohio, USA
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José I Piruat
José I Piruat
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Seville, Spain
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José López-Barneo
José López-Barneo
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Seville, Spain
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Sissy M Jhiang
Sissy M Jhiang
Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA
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Lawrence S Kirschner
Lawrence S Kirschner
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA
Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
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Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
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transcription factors and cellular production of the thyroid stem cell marker ALDH. Although the tumor cells retained sufficiently differentiated function to maintain normal thyroid function, the acquisition of stem-like features is likely to play an important
