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Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway
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Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway
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Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway
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Exercise training has been hypothesized to lower the inflammatory burden for patients with cancer, but the role of exercise intensity is unknown. To this end, we compared the effects of high-intensity (HI) and low-to-moderate intensity (LMI) exercise on markers of inflammation in patients with curable breast, prostate and colorectal cancer undergoing primary adjuvant cancer treatment in a secondary analysis of the Phys-Can randomized trial (NCT02473003). Sub-group analyses focused on patients with breast cancer undergoing chemotherapy. Patients performed 6 months of combined aerobic and resistance exercise on either HI or LMI during and after primary adjuvant cancer treatment. Plasma taken at baseline, immediately post-treatment and post-intervention was analyzed for levels of interleukin 1 beta (IL1B), IL6, IL8, IL10, tumor-necrosis factor alpha (TNFA) and C-reactive protein (CRP). Intention-to-treat analyses of 394 participants revealed no significant between-group differences. Regardless of exercise intensity, significant increases of IL6, IL8, IL10 and TNFA post-treatment followed by significant declines, except for IL8, until post-intervention were observed with no difference for CRP or IL1B. Subgroup analyses of 154 patients with breast cancer undergoing chemotherapy revealed that CRP (estimated mean difference (95% CI): 0.59 (0.33; 1.06); P = 0.101) and TNFA (EMD (95% CI): 0.88 (0.77; 1); P = 0.053) increased less with HI exercise post-treatment compared to LMI. Exploratory cytokine co-regulation analysis revealed no difference between the groups. In patients with breast cancer undergoing chemotherapy, HI exercise resulted in a lesser increase of CRP and TNFA immediately post-treatment compared to LMI, potentially protecting against chemotherapy-related inflammation.
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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study was to evaluate whether a combination of clinical parameters and cytokine profiles in ascites can predict survival in patients with ovarian cancer. Therefore, Th1 (interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα))-, Th2 (IL4, IL6, and
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ezpression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes 52 1779 –1785. Key TJ , Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C
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tumorigenesis, inflammation, and apoptosis and thus promotes tumor progression. Constitutive activation of NFKB is frequently observed in medullary thyroid cancer and NFKB protects pancreatic islet cells from tumor necrosis factor alpha-mediated cell death
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osteoclasts . Journal of Biological Chemistry 278 44667 – 44674 . Webster JC Huber RM Hanson RL Collier PM Haws TF Mills JK Burn TC Allegretto EA 2002 Dexamethasone and tumor necrosis factor-alpha
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://doi.org/10.1111/jne.12614 ) 29869822 10.1111/jne.12614 Candolfi M Jaita G Zaldivar V Zarate S Ferrari L Pisera D Castro MG Seilicovich A 2005 Progesterone antagonizes the permissive action of estradiol on tumor necrosis factor-alpha-induced apoptosis of
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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interleukin-6, but not tumor necrosis factor-alpha, in vivo . Journal of Clinical Endocrinology and Metabolism 82 4196 – 4200 doi:10.1210/jc.82.12.4196 . Orban Z Remaley AT Sampson M Trajanoski Z Chrousos GP 1999 The differential effect of
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papillary thyroid cancer. Clinical Endocrinology 56 53 –63. Grey A , Mitnick MA, Shapses S, Ellison A, Gundberg C & Insogna K 1996 Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary
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negatively regulated by cytokines, such as interleukin-1 beta and tumor necrosis factor alpha. However, stimulatory or inhibitory effects of these molecules depend on the type of cytokine, the species and the organ studied ( Ongphiphadhanakul et al. 1994
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& Baxter RC 2005 Enhancement of tumor necrosis factor-alpha-induced growth inhibition by insulin-like growth factor-binding protein-5 (IGFBP-5), but not IGFBP-3 in human breast cancer cells. Endocrinology 146 3113 –3122