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Elena Valassi IIB-Sant Pau and Department of Endocrinology/Medicine, Hospital Sant Pau and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain
Universitat Internacional de Catalunya (UIC), Barcelona, Spain

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Frédéric Castinetti Department of Endocrinology, Aix Marseille University, AP-HM, INSERM, Marseille Medical Genetics, Marmara Institute, La Conception Hospital, Marseille, France

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Amandine Ferriere Department of Endocrinology, Diabetes and Nutrition, University of Bordeaux, Bordeaux, France

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Stylianos Tsagarakis Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece

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Richard A Feelders Erasmus Medical Center, Division of Endocrinology, Department of Internal Medicine, Rotterdam, The Netherlands

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Romana T Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Michael Droste Praxis für Endokrinologie Dr. med. Michael Droste, Oldenburg, Germany

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Christian J Strasburger Division of Clinical Endocrinology, Department of Medicine CCM, Charité-Universitätsmedizin, Berlin, Germany

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Dominique Maiter Service d’Endocrinologie et Nutrition, Cliniques universitaires Saint Luc, Brussels, Belgium

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Darko Kastelan Department of Endocrinology, University Hospital Zagreb, Zagreb, Croatia

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Philippe Chanson Institut National de la Santé et de la Recherche Médicale, U1185, Le Kremlin, Bicêtre, Paris, France

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Susan M Webb IIB-Sant Pau and Department of Endocrinology/Medicine, Hospital Sant Pau and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Frank Demtröder Zentrum für Endokrinologie, Diabetologie, Rheumatologie Dr. Demtröder & Kollegen, Dortmund, Germany

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Valdis Pirags Paula Stradiņa klīniskā universitātes slimnīca, Riga, Latvia

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Olivier Chabre Hospitalier Universitaire, Grenoble, France

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Holger Franz Lohmann & Birkner Health Care Consultimg GmbH, Berlin, Germany

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Alicia Santos IIB-Sant Pau and Department of Endocrinology/Medicine, Hospital Sant Pau and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Martin Reincke Medizinische Klinik UND Poliklinik IV, Campus Innestadt, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany

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( Fountas & Karavitaki 2020 ). A recent consensus recognized the presence of an expanding adenoma on imaging as the most accurate diagnostic criterion of NS and, accordingly, proposed the definition of ‘corticotroph tumor progression after bilateral

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Anna Bagnato Molecular Pathology and Ultrastructure Laboratory, Regina Elena Cancer Institute, Via delle Messi d’Oro 156, 00158 Rome, Italy

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Francesca Spinella Molecular Pathology and Ultrastructure Laboratory, Regina Elena Cancer Institute, Via delle Messi d’Oro 156, 00158 Rome, Italy

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Laura Rosanò Molecular Pathology and Ultrastructure Laboratory, Regina Elena Cancer Institute, Via delle Messi d’Oro 156, 00158 Rome, Italy

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patients in advanced stages is still associated by low survival rates, the development of new treatment protocols depends on improved knowledge of the molecular mechanisms controlling tumor progression ( Naora & Montell 2005 ). Cancer invasion is a state

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Yvonne Fierz Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

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Ruslan Novosyadlyy Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

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Archana Vijayakumar Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

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Shoshana Yakar Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

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Derek LeRoith Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

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the setting of type 2 diabetes are largely unknown. To study the effect of mTOR blockade on type 2 diabetes-induced mammary tumor progression, we employed a hyperinsulinemic mouse model of type 2 diabetes, the female MKR mice. These mice overexpress

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A Bardin
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N Boulle
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G Lazennec
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F Vignon
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P Pujol
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feature of estrogen-dependent tumor progression in clinical studies Analysis of ERα and ERβ expression in estrogen-sensitive cancers (Tables 1–4) In breast tissues, several studies have indicated an increase in ERα/ERβ mRNA

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Annu Makker Post Graduate Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

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Madhu Mati Goel Post Graduate Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

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in CTNNB1 , PPP21A , and p53 genes have been suggested to contribute to tumor progression from EEC to UEC ( Kuhn et al . 2014 ). Although the overall 5-year survival rate in patients with stage I EEC approaches 90%, ∼30% of these tumors are high

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Zane Hammoud Department of Obstetrics and Gynecology, Thoracic Surgery, Pathology, Indiana University School of Medicine, 975 West Walnut Street (IB360), Indianapolis, Indiana 46202-5121, USA Departments of

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Bailin Tan
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Sunil Badve Department of Obstetrics and Gynecology, Thoracic Surgery, Pathology, Indiana University School of Medicine, 975 West Walnut Street (IB360), Indianapolis, Indiana 46202-5121, USA Departments of

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Robert M Bigsby
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that estrogen increased tumor grade in males ( P <0.001), but not in ovariectomized females ( Fig. 4 ). Figure 4 Effect of estradiol on tumor progression. Using a scale described by Jackson et al . (2005) for grading mouse lung tumors, histological

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Louis de Mestier
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Clarisse Dromain Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Gaspard d'Assignies Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Jean-Yves Scoazec Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Nathalie Lassau Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Rachida Lebtahi Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Hedia Brixi
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Emmanuel Mitry Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Rosine Guimbaud Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Frédéric Courbon Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Michèle d'Herbomez Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Guillaume Cadiot
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SD: no criteria for CR, PR, or PD and no symptomatic deterioration attributed to tumor progression PD: ≥10% increase in the sum of diameters, increase in size of existing intra-tumoral nodules, new lesion, or intra-tumor nodule Chun

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Teresa Ramone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Cristina Romei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Raffaele Ciampi Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Roberta Casalini Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Angelo Valetto Department of Laboratory Medicine, Section of Cytogenetics, University Hospital of Pisa, Pisa, Italy

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Veronica Bertini Department of Laboratory Medicine, Section of Cytogenetics, University Hospital of Pisa, Pisa, Italy

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Francesco Raimondi Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore, Pisa, Italy

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Anthony Onoja Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Paolo Piaggi Department of Information Engineering, University of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Pathology, University Hospital of Pisa, Pisa, Italy

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Clara Ugolini Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Pathology, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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et al. 2007 ). In fact, the amplification of chromosomal regions containing oncogenes involved in tumor progression or the loss of regions containing TSG could justify the correlation between SCNA and metastatic progression and poor outcomes of the

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Nikki A Ford Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Nomeli P Nunez Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Valerie B Holcomb Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Stephen D Hursting Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA
Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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). Furthermore, the Met1 cell line, derived from a spontaneous tumor from a polyoma middle-T antigen transgenic mouse, progressively loses ER and progesterone receptor positivity with tumor progression, therefore providing a rapid and relevant model for studying

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Clay E S Comstock Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Karen E Knudsen Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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with the conclusion that tumor progression is largely driven by resurgent AR activity, hormone therapy ‘failure’ is typically first detected by a rise in PSA despite the maintenance of ligand depletion and AR-directed therapeutic regimens, indicating

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