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John W Cassidy Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Ankita S Batra Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Wendy Greenwood Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Alejandra Bruna Department of Oncology, University of Cambridge, Cambridge, UK

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-derived tumour xenografts (PDTXs) ( Whittle et al. 2015 ), which retain the complex heterogeneity of their originating tumour samples ( DeRose et al. 2011 , Cassidy et al. 2015 , Eirew et al. 2015 ). PDTX models of BC resemble primary tumours across the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0251
Volume/Issue:
Volume 23: Issue 12
Open access
Audrey Ziverec Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Marie Chanal Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Perrine Raymond Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Mirela Diana Ilie Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France
Endocrinology Department, “C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania

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Dario De Alcubierre Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Arja Pasternack Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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Olli Ritvos Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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Gerald Raverot Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France
Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France
Department of Endocrinology, Reference center for rare pituitary disease (HYPO), Groupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France

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Philippe Bertolino Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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of CSF-1 ( Principe et al. 2020 ). These results support the existence of paracrine effects that may be modulated by LβT2 cells in vivo , confirming the need to explore their behaviour and cellular interactions in the context of tumour xenografts

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0245
Volume/Issue:
Volume 30: Issue 3
Restricted access
Silvana Libertini
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Antonella Abagnale
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Carmela Passaro
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Ginevra Botta
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Sara Barbato
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Paolo Chieffi Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento di Medicina Sperimentale, Facoltà di Medicina e Chirurgia, Università di Napoli Federico II, Via S. Pansini 5, 80131 Napoli, Italy

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Giuseppe Portella
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); a phase I trial of dl922-947 in women with relapsed ovarian cancer is under way ( Baird et al . 2008 ). We have shown that dl922-947 is active against ATC cell lines and tumour xenografts ( Libertini et al . 2008 ). However, data accumulated so

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0234
Volume/Issue:
Volume 18: Issue 1
Free access
Haleh Vosgha Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

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Armin Ariana Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

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Robert Anthony Smith Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
Genomics Research Centre, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia

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Alfred King-yin Lam Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

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ability of endothelial cells was imaged using an inverted microscope 4× magnification. Wimasis WimTube (Wimasis GmbH, Munich, Germany) software was used to analyse the number of loops and number of branching points. Tumour xenografts studies in mice

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0497
Volume/Issue:
Volume 25: Issue 3
Free access
Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Anja Rockstroh Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Martin C Sadowski Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Atefeh Taherian Fard Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Gregor Tevz Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Michelle S Libério Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Charles L Bidgood Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Jennifer H Gunter Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Stephen McPherson Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Nenad Bartonicek Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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John D Wade Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
School of Chemistry, University of Melbourne, Melbourne, Victoria, Australia

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Laszlo Otvos OLPE, LLC, Audubon, Pennsylvania, USA
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary

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Colleen C Nelson Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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. Figure 4 (A, B, C, D, E, F, G and H). Efficacious effects of Allo-aca in preventing tumour progression in LNCaP xenograft progression model in castrate nude mice. Impact of Allo-aca on tumour xenograft (A) doubling time (^in cohort growth inhibition

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0405
Volume/Issue:
Volume 28: Issue 5
Restricted access
Lisa K Philp Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Anja Rockstroh Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia
Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada

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Martin C Sadowski Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Nenad Bartonicek Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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John D Wade Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
School of Chemistry, University of Melbourne, Melbourne, Victoria, Australia

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Laszlo Otvos Jr OLPE, LLC, Audubon, Pennsylvania, USA
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary

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Colleen C Nelson Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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reproducible nature of the LNCaP line to model PCa progression in vivo (androgen-sensitive, AR-positive, secretes PCa biomarker PSA). ADIPOR agonism suppresses tumour growth in vivo Daily administration of ADP355 slowed LNCaP tumour xenograft

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0297
Volume/Issue:
Volume 27: Issue 12
Restricted access
Giovanni Vitale Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy
Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Germano Gaudenzi Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Luisa Circelli Department of Experimental Oncology, Laboratory of Molecular Biology and Viral Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, ‘Fondazione Pascale’ – IRCCS, Naples, Italy

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Marco F Manzoni Department of Endocrinology and Internal Medicine, Endocrine Tumors Unit, San Raffaele Hospital Vita-Salute San Raffaele University, Milan, Italy

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Andrea Bassi Department of Physics, Politecnico di Milano, Milan, Italy

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Niccolò Fioritti Department of Biosciences, University of Milan, Milan, Italy

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Antongiulio Faggiano Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione G. Pascale’ – IRCCS, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, Section of Endocrinology, ‘Federico II’ University of Naples, Naples, Italy

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on behalf of NIKE Group Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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-Viqueira & Hidalgo 2009 ). Another type of xenograft model used in research is the ‘patient-derived tumour xenograft’ (PDX). This model is based on the transfer of primary tumour directly from the patient into an immunodeficient mouse. To accomplish this, patient

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0399
Volume/Issue:
Volume 24: Issue 1
Free access
D Alwyn Dart
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Bradley Spencer-Dene Androgen Signalling Laboratory, Department of Histopathology, Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK

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Simon C Gamble
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Jonathan Waxman
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Charlotte L Bevan
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on growth of LNCaP/Luc tumour xenografts in nude mice. (A) Relative tumour volume (RTV) of LNCaP/Luc tumours over 36 days. Each point represents the mean± s.e.m . of six to eight observations. Treatment groups assigned on day 20. ** P <0.01, * P <0

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0028
Volume/Issue:
Volume 16: Issue 4
Open access
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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, Australia

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processes. The authors highlight the influence of factors such as the extracellular matrix on the biology of cancer cells and introduce the recent evolution of patient-derived tumour xenograft (PDTX) models. The review highlights how PDTX models better

Article Type:
Editorial
DOI:
https://doi.org/10.1530/ERC-16-0466
Volume/Issue:
Volume 23: Issue 12
Free access
Tobias Hofving Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Viktor Sandblom Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Yvonne Arvidsson Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Emman Shubbar Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Gülay Altiparmak Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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John Swanpalmer Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden

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Bilal Almobarak Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Anna-Karin Elf Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Viktor Johanson Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Erik Elias Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Erik Kristiansson Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden

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Eva Forssell-Aronsson Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden

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Ola Nilsson Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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replicates and was performed once due to the limited cell numbers. Cell plates were analysed 72 h after the start of the experiment. Tumour xenograft model and animal handling GOT1 tissue was transplanted subcutaneously to BALB/c nude mice (Janvier

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0509
Volume/Issue:
Volume 26: Issue 4
Open access