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C Verdelli Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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L Avagliano Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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P Creo Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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V Guarnieri Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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A Scillitani Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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L Vicentini Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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G B Steffano Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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E Beretta Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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L Soldati Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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E Costa Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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A Spada Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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G P Bulfamante Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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S Corbetta Laboratory of Molecular Biology, Department of Human Pathology, Laboratory of Stem Cells for Tissue Engineering, Medical Genetics, Endocrinology Unit, Endocrine Surgery, Surgery Unit, Surgery Unit, Department of Health Sciences, Endocrinology and Diabetology Unit, Endocrinology and Diabetology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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important target for cancer therapy. Fibroblasts within the tumour stroma are critically involved in promoting tumour growth and angiogenesis through secretion of soluble factors, synthesis of extracellular matrix and direct cell–cell interaction. Tumour-associated

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Pedro Marques Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Sayka Barry Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Eivind Carlsen Department of Pathology, STHF, Skien, Norway

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David Collier Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Amy Ronaldson Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Sherine Awad Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Neil Dorward The National Hospital for Neurology and Neurosurgery, UCLH, NHS Trust, London, UK

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Joan Grieve The National Hospital for Neurology and Neurosurgery, UCLH, NHS Trust, London, UK

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Nigel Mendoza Department of Neurosurgery, Charing Cross Hospital, Imperial College, London, UK

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Samiul Muquit Department of Neurosurgery, Derriford Hospital, Plymouth, UK

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Ashley B Grossman Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Frances Balkwill Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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fibroblasts undergo activation in tumours, often then termed as tumour-associated fibroblasts (TAFs) ( Cirri & Chiarugi 2012 , Shiga et al. 2015 ). TAFs are an important source of cytokines and growth factors which contribute to their pro-tumoural effects

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Xiang Zhang Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Ya Hu Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Ming Cui Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Mengyi Wang Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Xiaobin Li Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Yalu Zhang Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Sen Yang Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Surong Hua Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Meiping Shen Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Quan Liao Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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profile the transcriptome of 27,251 cells isolated from 4 PA tissues. Our work revealed the cellular heterogeneity, transcriptional states, and immune cell diversity inside PA tissues, underlying the role of tumour-associated fibroblasts (TAFs) and immune

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Chiara Verdelli Laboratory of Experimental Endocrinology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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Irene Forno Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy

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Annamaria Morotti Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy
Endocrine Surgery, IRCCS Ospedale San Raffaele, Milan, Italy

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Riccardo Maggiore Endocrine Surgery, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Gilberto Mari Endocrine Surgery, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Leonardo Vicentini Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Stefano Ferrero Endocrine Surgery, IRCCS Ospedale San Raffaele, Milan, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

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Elisabetta Kuhn Endocrine Surgery, IRCCS Ospedale San Raffaele, Milan, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

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Valentina Vaira Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy
Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Sabrina Corbetta Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
Endocrinology and Diabetology Service, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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. Oncogene 31 27 – 38 . ( https://doi.org/10.1038/onc.2011.209 ) Verdelli C Avagliano L Creo P Guarnieri V Scillitani A Vicentini L Steffano GB Beretta E Soldati L Costa E et al . 2015a Tumour-associated fibroblasts contribute to

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W Nathaniel Brennen Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB-I, Room 1M44, Baltimore, Maryland 21287, USA

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Samuel R Denmeade Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB-I, Room 1M44, Baltimore, Maryland 21287, USA

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John T Isaacs Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB-I, Room 1M44, Baltimore, Maryland 21287, USA

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.1002/pmic.200700089 ). Paunescu V Bojin FM Tatu CA Gavriliuc OI Rosca A Gruia AT Tanasie G Bunu C Crisnic D Gherghiceanu M 2011 Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences

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Vincenzo Condello Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, Pisa, Italy
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Filomena Cetani Endocrine Unit, University Hospital of Pisa, Pisa, Italy

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Maria Denaro Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, Pisa, Italy

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Liborio Torregrossa Division of Surgical Pathology, University Hospital of Pisa, Pisa, Italy

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Elena Pardi Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Paolo Piaggi Department of Information Engineering, University of Pisa, Pisa, Italy

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Simona Borsari Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Anello Marcello Poma Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, Pisa, Italy

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Lucia Anna Muscarella Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, Laboratory of Oncology, San Giovanni Rotondo (FG), Italy

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Paolo Graziano Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, Unit of Pathology, San Giovanni Rotondo (FG), Italy

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Maria Grazia Chiofalo Fondazione IRCCS G. Pascale, Thyroid and Parathyroid Surgery Unit, Istituto Nazionale Tumori, Naples, Italy

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Andrea Repaci Endocrinology Unit, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

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Giovanni Tallini Department of Medicine, Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy

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Francesco Boi Department of Medical Sciences and Public Health, Endocrinology Unit, University of Cagliari, Cagliari, Italy

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Gabriele Materazzi Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, Pisa, Italy

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Fulvio Basolo Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, Pisa, Italy

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Claudio Marcocci Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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L Costa E et al . 2015 Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia . Endocrine-Related Cancer 22 87 – 98 . ( https://doi.org/10.1530/ERC-14-0161 ) Verdelli C Avagliano L Guarnieri V

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Filomena Cetani University Hospital of Pisa, Unit of Endocrinology, Pisa, Italy

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Claudio Marcocci Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Liborio Torregrossa University Hospital of Pisa, Division of Surgical Pathology, Pisa, Italy

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Elena Pardi Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Soldati L Costa E , et al . 2015 Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia . Endocrine-Related Cancer 22 . ( https://doi.org/10.1530/ERC-14-0161 ) 25515730 Verdelli C Forno I Morotti A

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