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important target for cancer therapy. Fibroblasts within the tumour stroma are critically involved in promoting tumour growth and angiogenesis through secretion of soluble factors, synthesis of extracellular matrix and direct cell–cell interaction. Tumour-associated
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fibroblasts undergo activation in tumours, often then termed as tumour-associated fibroblasts (TAFs) ( Cirri & Chiarugi 2012 , Shiga et al. 2015 ). TAFs are an important source of cytokines and growth factors which contribute to their pro-tumoural effects
Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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profile the transcriptome of 27,251 cells isolated from 4 PA tissues. Our work revealed the cellular heterogeneity, transcriptional states, and immune cell diversity inside PA tissues, underlying the role of tumour-associated fibroblasts (TAFs) and immune
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Endocrinology and Diabetology Service, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
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. Oncogene 31 27 – 38 . ( https://doi.org/10.1038/onc.2011.209 ) Verdelli C Avagliano L Creo P Guarnieri V Scillitani A Vicentini L Steffano GB Beretta E Soldati L Costa E et al . 2015a Tumour-associated fibroblasts contribute to
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.1002/pmic.200700089 ). Paunescu V Bojin FM Tatu CA Gavriliuc OI Rosca A Gruia AT Tanasie G Bunu C Crisnic D Gherghiceanu M 2011 Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences
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L Costa E et al . 2015 Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia . Endocrine-Related Cancer 22 87 – 98 . ( https://doi.org/10.1530/ERC-14-0161 ) Verdelli C Avagliano L Guarnieri V
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Soldati L Costa E , et al . 2015 Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia . Endocrine-Related Cancer 22 . ( https://doi.org/10.1530/ERC-14-0161 ) 25515730 Verdelli C Forno I Morotti A