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Isadora Pontes Cavalcante, Anna Vaczlavik, Ludivine Drougat, Claudimara Ferini Pacicco Lotfi, Karine Perlemoine, Christopher Ribes, Marthe Rizk-Rabin, Eric Clauser, Maria Candida Barisson Villares Fragoso, Jérôme Bertherat and Bruno Ragazzon

protein involved in the ubiquitin-proteasome system (UPS), mediating the ubiquitination process and leading to target proteins to the 26S proteasome complex ( Ciechanover 2017 , Dubiel et al . 2018 ). UPS regulates various important cellular processes

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Carl Weidinger, Kerstin Krause, Antje Klagge, Stefan Karger and Dagmar Fuhrer

posttranslational modifications (PTMs) such as phosphorylation, acetylation and ubiquitination ( Fig. 2 ; Van Der Heide et al . 2004 , Vogt et al . 2005 , van der Horst & Burgering 2007 , Huang & Tindall 2007 , Reagan-Shaw & Ahmad 2006 ). PTMs of FOXOs ensure

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Matthew Saldana, Kacey VanderVorst, Anastasia L Berg, Hyun Lee and Kermit L Carraway III

Introduction Ubiquitination, the post-translational addition of the ubiquitin protein to target proteins, controls various cellular processes by altering protein stability, localization, activity or interactions. This process is accomplished

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Alexander J Cole, Roderick Clifton-Bligh and Deborah J Marsh

2004 ). Lysine 34 on histone H2B can also be monoubiquitinated and is involved in histone cross-talk; however, it appears to utilise different ubiquitination machinery compared with H2Bub1 and its role in the regulation of chromatin structure, if any

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Suzan Stelloo, Simon Linder, Ekaterina Nevedomskaya, Eider Valle-Encinas, Iris de Rink, Lodewyk F A Wessels, Henk van der Poel, Andries M Bergman and Wilbert Zwart

binding in a window of 20-kb upstream or within their gene body. Using ingenuity pathway analysis, we found that XBP1s target genes were enriched for genes involved in the unfolded protein response, eIF2 signaling and protein ubiquitination with no

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Gennaro Chiappetta, Carmela De Marco, Alfina Quintiero, Daniela Califano, Simona Gherardi, Donatella Malanga, Marianna Scrima, Cristina Montero-Conde, Letizia Cito, Mario Monaco, Maria Letizia Motti, Rosa Pasquinelli, Valter Agosti, Mercedes Robledo, Alfredo Fusco and Giuseppe Viglietto

specificity ( Patton et al. 1998 , Deshaies 1999 ). Each F-box protein recognizes a specific subset of protein substrates and thus promotes their ubiquitination and subsequent degradation ( Kipreos & Pagano 2000 , Jin et al. 2004 ). The F

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K S Kimbro and J W Simons

–loop–helix (bHLH)-PER-ARNT-Sim (PAS) family of transcription factors. They share a conserved bHLH region for DNA binding, and two PAS domains for target gene specificity and dimerization. HIF-1α is regulated post-transcriptionally in normoxia by ubiquitination and

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Zhengping Zhuang, Chunzhang Yang, Ales Ryska, Yuan Ji, Yingyong Hou, Sky D Graybill, Petra Bullova, Irina A Lubensky, Günter Klöppel and Karel Pacak

affects its protein ubiquitination in the presence of oxygen. Figure 1 Histopathological features of GPGLs from patient 1 (A) and patient 2 (B). In both tumors, the neoplastic cells were arranged in solid nests, trabeculae, and fascicules with areas

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Eric Glasgow and Lopa Mishra

TGF-β signaling by ubiquitinators Interactions involving ubiquitination are an integral part of the TGF-β/Smad signaling pathway ( Fig. 1 ). The ubiquitin–proteasome system is composed of two discrete steps. First, multiple ubiquitin molecules are

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Deborah J Marsh

his review in this special issue of Endocrine-Related Cancer on Ubiquitination and Cancer, Johnson 2015 describes how aberrant expression of oncogenes and/or tumour suppressors can disrupt normal cellular processes such as cell cycle progression or