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Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China
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et al. 2011 , Scarpa et al. 2017 ), small intestine ( Banck et al. 2013 , Francis et al. 2013 ), and lung ( Gabriel et al. 2020 ), while the genomic data based on whole-exome sequencing in R-NETs was absent. Evidence has shown that the
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Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
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Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
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secondary mutations in growth-promoting genes have been reported in APA with mutations in aldosterone-driver genes so far. In this study, we used whole-exome sequencing (WES) to characterize the landscape of somatic alterations in a homogeneous series of
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Service of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
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Department of Neurosurgery, Hôpital Foch, Suresnes, France
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Service d’Endocrinologie, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
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Department of Pathological Cytology and Anatomy, Hôpital Foch, Suresnes, France
Department of Endocrinology, CHU de Liège, University of Liège, Liège, Belgium
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defects in 23 corticotropinoma DNA samples from these patients has been reported before ( Stratakis et al. 2010 , Trivellin et al. 2016 ). Germline DNA samples from 98 patients and tumor DNA samples from 28 of them were submitted for whole-exome
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sensitivity. In this paper, we report the immunophenotyping, genome-wide copy number profiling, whole-exome sequencing and comprehensive inhibitor screening of seven GEPNET cell lines. We confirmed the neuroendocrine phenotype of GOT1, P-STS, BON-1 and QGP-1
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investigated the genetic landscape of ATC cell lines using SNP array analysis, RNA sequencing and whole exome sequencing (WES). We found that ATC cell lines display highly complex genomes, with multiple breakpoints and large variation in copy numbers. We
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Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
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whole-exome sequencing. Materials and methods Samples The study cohort consisted of 14 women known to have both primary breast and thyroid cancer malignancies. They were identified from a cohort of study participants who consented to participate in
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Unidade de Hipertensão, Disciplina de Nefrologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Endocrinology, Metabolism and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
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Servico de Endocrinologia, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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.e.m. Comparisons were carried out via unpaired two-tailed t test. P- value <0.05 was considered significant. Results Whole exome sequencing All cases underwent unilateral adrenalectomy guided by CT or because of inconclusive lateralization index at
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Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
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Carling Adrenal Center, Tampa, Florida, USA
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Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital Stockholm, Sweden
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protein expression profiles and calcium currents. Material and methods Discovery PCC cohort Fifteen PCC cases from the Karolinska University Hospital were previously analyzed by whole-exome sequencing (WES). In a previous report, somatic
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
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School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Barbieri et al . (2012) in which new recurrently mutated genes were identified in primary PCa through whole-exome sequencing. Among the recurrently mutated genes identified, MED12 , encoding a subunit of the Mediator complex, is mutated in 5.4% of
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30% of sporadic parathyroid tumors ( Marx 2011 ). Screening a small number of sporadic parathyroid tumors by others, using whole exome sequencing analysis, did not show any CDKI gene mutation ( Cromer et al . 2012 , Newey et al . 2012 ). In a