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Yuanliang Li Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yiying Guo Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Zixuan Cheng Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Chao Tian Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yingying Chen Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Ruao Chen Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Fuhuan Yu Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yanfen Shi Department of Pathology, China-Japan Friendship Hospital, Beijing, China

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Fei Su Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China

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Shuhua Zhao Department of Biological Information Research, HaploX Biotechnology Co., Ltd, Shenzhen, Guangdong, China

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Zhizheng Wang Academic Department, HaploX Biotechnology, Co., Ltd, Shenzhen, Guangdong, China

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Jie Luo Department of Pathology, China-Japan Friendship Hospital, Beijing, China

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Huangying Tan Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China

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et al. 2011 , Scarpa et al. 2017 ), small intestine ( Banck et al. 2013 , Francis et al. 2013 ), and lung ( Gabriel et al. 2020 ), while the genomic data based on whole-exome sequencing in R-NETs was absent. Evidence has shown that the

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Antonio M Lerario Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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Kazutaka Nanba Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Amy R Blinder Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Sachiko Suematsu Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan

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Masao Omura Medical Checkup Clinic, Minatomirai Medical Square, Sowa-Group, Yokohama, Japan

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Tetsuo Nishikawa Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan

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Thomas J Giordano Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA

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William E Rainey Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Tobias Else Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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secondary mutations in growth-promoting genes have been reported in APA with mutations in aldosterone-driver genes so far. In this study, we used whole-exome sequencing (WES) to characterize the landscape of somatic alterations in a homogeneous series of

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Laura C Hernández-Ramírez Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Ryhem Gam Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada

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Nuria Valdés Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
Service of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain

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Maya B Lodish Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Nathan Pankratz Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Aurelio Balsalobre Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada

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Yves Gauthier Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada

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Fabio R Faucz Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Giampaolo Trivellin Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Prashant Chittiboina Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA

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John Lane Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Denise M Kay Newborn Screening Program, Wadsworth Center, New York State Department of Health, Albany, New York, USA

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Aggeliki Dimopoulos Division of Intramural Population Health Research, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Stephan Gaillard Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France
Department of Neurosurgery, Hôpital Foch, Suresnes, France

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Mario Neou Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France

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Jérôme Bertherat Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France
Service d’Endocrinologie, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France

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Guillaume Assié Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France
Service d’Endocrinologie, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France

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Chiara Villa Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Paris, France
Department of Pathological Cytology and Anatomy, Hôpital Foch, Suresnes, France
Department of Endocrinology, CHU de Liège, University of Liège, Liège, Belgium

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James L Mills Division of Intramural Population Health Research, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Jacques Drouin Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada

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Constantine A Stratakis Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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defects in 23 corticotropinoma DNA samples from these patients has been reported before ( Stratakis et al. 2010 , Trivellin et al. 2016 ). Germline DNA samples from 98 patients and tumor DNA samples from 28 of them were submitted for whole-exome

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Tobias Hofving Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Yvonne Arvidsson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Bilal Almobarak Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Linda Inge Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Roswitha Pfragner Institute of Pathophysiology and Immunology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria

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Marta Persson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Göran Stenman Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Erik Kristiansson Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden

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Viktor Johanson Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Ola Nilsson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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sensitivity. In this paper, we report the immunophenotyping, genome-wide copy number profiling, whole-exome sequencing and comprehensive inhibitor screening of seven GEPNET cell lines. We confirmed the neuroendocrine phenotype of GOT1, P-STS, BON-1 and QGP-1

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Eleanor L Woodward Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Andrea Biloglav Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Naveen Ravi Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Minjun Yang Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Lars Ekblad Division of Oncology and Pathology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden

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Johan Wennerberg Division of Otorhinolaryngology/Head and Neck Surgery, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden

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Kajsa Paulsson Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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investigated the genetic landscape of ATC cell lines using SNP array analysis, RNA sequencing and whole exome sequencing (WES). We found that ATC cell lines display highly complex genomes, with multiple breakpoints and large variation in copy numbers. We

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Yuji Ikeda Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Kazuma Kiyotani Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Poh Yin Yew Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Taigo Kato Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Kenji Tamura Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Kai Lee Yap Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Sarah M Nielsen Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Jessica L Mester Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Charis Eng Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Yusuke Nakamura Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Raymon H Grogan Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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whole-exome sequencing. Materials and methods Samples The study cohort consisted of 14 women known to have both primary breast and thyroid cancer malignancies. They were identified from a cohort of study participants who consented to participate in

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Marcela Rassi-Cruz Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Andrea G Maria Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA

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Fabio R Faucz Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA

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Edra London Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA

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Leticia A P Vilela Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Lucas S Santana Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Anna Flavia F Benedetti Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Tatiana S Goldbaum Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Fabio Y Tanno Serviço de Urologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Vitor Srougi Serviço de Urologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Jose L Chambo Serviço de Urologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Maria Adelaide A Pereira Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Aline C B S Cavalcante Instituto de Radiologia InRad, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Francisco C Carnevale Instituto de Radiologia InRad, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Bruna Pilan Instituto de Radiologia InRad, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Luiz A Bortolotto Unidade de Hipertensão, Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Luciano F Drager Unidade de Hipertensão, Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Unidade de Hipertensão, Disciplina de Nefrologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Antonio M Lerario Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Endocrinology, Metabolism and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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Ana Claudia Latronico Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Maria Candida B V Fragoso Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Servico de Endocrinologia, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Berenice B Mendonca Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Maria Claudia N Zerbini Divisão de Anatomia Patológica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Constantine A Stratakis Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA

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Madson Q Almeida Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Servico de Endocrinologia, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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.e.m. Comparisons were carried out via unpaired two-tailed t test. P- value <0.05 was considered significant. Results Whole exome sequencing All cases underwent unilateral adrenalectomy guided by CT or because of inconclusive lateralization index at

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Fredrika Svahn Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Karolina Solhusløkk Höse Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Adam Stenman Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Yaxuan Liu Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China

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Jan Calissendorff Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

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Emma Tham Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden

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Ákos Végvári Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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Roman A Zubarev Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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Na Wang Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden

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Reju Korah Yale Endocrine Neoplasia Laboratory, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA

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Tobias Carling Yale Endocrine Neoplasia Laboratory, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA
Carling Adrenal Center, Tampa, Florida, USA

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Jan Zedenius Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Robert Bränström Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital Stockholm, Sweden

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Catharina Larsson Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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protein expression profiles and calcium currents. Material and methods Discovery PCC cohort Fifteen PCC cases from the Karolinska University Hospital were previously analyzed by whole-exome sequencing (WES). In a previous report, somatic

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David Adler Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Anne Offermann Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Martin Braun Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Roopika Menon Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Isabella Syring Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Michael Nowak Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Rebecca Halbach Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Wenzel Vogel Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Christian Ruiz Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Tobias Zellweger Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Cyrill A Rentsch Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Maria Svensson Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Ove Andren Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Lukas Bubendorf Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Saskia Biskup Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Stefan Duensing Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Jutta Kirfel Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Sven Perner Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Barbieri et al . (2012) in which new recurrently mutated genes were identified in primary PCa through whole-exome sequencing. Among the recurrently mutated genes identified, MED12 , encoding a subunit of the Mediator complex, is mutated in 5.4% of

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Thomas Gluick Genetics and Endocrinology Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Departments of Surgery and Genetics, Albert Einstein College of Medicine, Bld 10, Room 9C-103, 10 Center Drive, Bethesda, Maryland, 20892, USA

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Ziqiang Yuan Genetics and Endocrinology Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Departments of Surgery and Genetics, Albert Einstein College of Medicine, Bld 10, Room 9C-103, 10 Center Drive, Bethesda, Maryland, 20892, USA

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Steven K Libutti Genetics and Endocrinology Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Departments of Surgery and Genetics, Albert Einstein College of Medicine, Bld 10, Room 9C-103, 10 Center Drive, Bethesda, Maryland, 20892, USA

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Stephen J Marx Genetics and Endocrinology Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Departments of Surgery and Genetics, Albert Einstein College of Medicine, Bld 10, Room 9C-103, 10 Center Drive, Bethesda, Maryland, 20892, USA

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30% of sporadic parathyroid tumors ( Marx 2011 ). Screening a small number of sporadic parathyroid tumors by others, using whole exome sequencing analysis, did not show any CDKI gene mutation ( Cromer et al . 2012 , Newey et al . 2012 ). In a

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