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Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Introduction It has long been known that androgens are critical in the growth and progression of prostate cancer ( Dehm & Tindall 2006 ). Androgens signal through the androgen receptor (AR), a member of the steroid receptor family of transcription
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acquiring comprehensive information for metastatic tumors is needed to improve clinical outcomes. Similar to ER and PR, androgen receptor (AR) is a member of the steroid nuclear receptor family ( Basile et al . 2017 ), playing an important role in the
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The androgen receptor: gene, mRNA, and protein The androgen receptor (AR) is a 110 kDa member of the steroid receptor transcription factor family that mediates the cellular actions of the androgens testosterone and dihydrotestosterone (DHT). The
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Introduction Androgens regulate numerous physiological responses from male sexual development to bone and muscle growth. The biological action of androgens is mediated through the androgen receptor (AR), a ligand
Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium
Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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not within the context of a multimodal approach. In the metastatic setting, androgen deprivation therapy (ADT) is the mainstay treatment, targeting androgen receptor (AR) signaling. The first therapies, aimed at blocking AR activity, were already being
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Introduction The androgen receptor (AR) is a ligand-dependent transcription factor of the nuclear receptor (NR) superfamily. Like other NRs, AR is composed of a N-terminal transactivation domain (NTD) harboring one or more hormone
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Introduction Prostate cancer is one of the most frequently diagnosed cancers in developed countries. Characteristically, prostate cancer depends on androgen receptor (AR) signaling for its carcinogenesis, development, and progression ( Basu
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Introduction AR receptor structure and signaling The androgen receptor (AR) is a member of the steroid hormone receptor family that in turn belongs to the superfamily of nuclear receptors. Other steroid hormone receptors include estrogen
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Introduction The androgen receptor (AR) is a steroid hormone receptor that is important in the development of male-specific phenotype. AR has a well-established canonical function as a ligand-activated transcription factor involved in the
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
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VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
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VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
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VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
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VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
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VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
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Introduction Prostate cancer (PCa) development and progression are regulated by the androgen receptor (AR), a steroid nuclear receptor, in both early and advanced stages of the disease ( Yuan et al . 2014 ). While localized PCa is mostly treated by