Search Results

You are looking at 1 - 10 of 392 items for :

  • Refine by access: All content x
Clear All
Xi Wei Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Search for other papers by Xi Wei in
Google Scholar
PubMed
Close
,
Shang Cai Department of Oncology, Southern Research Institute and Cancer Cell Biology Program, the University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, USA
Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China

Search for other papers by Shang Cai in
Google Scholar
PubMed
Close
,
Rebecca J Boohaker Department of Oncology, Southern Research Institute and Cancer Cell Biology Program, the University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, USA

Search for other papers by Rebecca J Boohaker in
Google Scholar
PubMed
Close
,
Joshua Fried Department of Oncology, Southern Research Institute and Cancer Cell Biology Program, the University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, USA

Search for other papers by Joshua Fried in
Google Scholar
PubMed
Close
,
Ying Li The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Search for other papers by Ying Li in
Google Scholar
PubMed
Close
,
Linfei Hu Department of Thyroid Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Search for other papers by Linfei Hu in
Google Scholar
PubMed
Close
,
Yi Pan Department of Thyroid Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Search for other papers by Yi Pan in
Google Scholar
PubMed
Close
,
Ruifen Cheng Department of Thyroid Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Search for other papers by Ruifen Cheng in
Google Scholar
PubMed
Close
,
Sheng Zhang Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Search for other papers by Sheng Zhang in
Google Scholar
PubMed
Close
,
Ye Tian Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China

Search for other papers by Ye Tian in
Google Scholar
PubMed
Close
,
Ming Gao Department of Thyroid Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Search for other papers by Ming Gao in
Google Scholar
PubMed
Close
, and
Bo Xu Department of Oncology, Southern Research Institute and Cancer Cell Biology Program, the University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, USA
Department of Molecular Radiation Oncology, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

Search for other papers by Bo Xu in
Google Scholar
PubMed
Close

overexpression and poor clinical prognosis. KAT5 promotes ATC cell invasion and proliferation through acetylating C-MYC, thus inhibiting ubiquitination proteasome degradation and stabilizing the protein. Furthermore, we demonstrate evidence that overexpression of

Free access
D J Liao Vincent T Lombardi Cancer Center, Georgetown University Medical Center, Washington DC 20007, USA.

Search for other papers by D J Liao in
Google Scholar
PubMed
Close
and
R B Dickson Vincent T Lombardi Cancer Center, Georgetown University Medical Center, Washington DC 20007, USA.

Search for other papers by R B Dickson in
Google Scholar
PubMed
Close

Ever since Bishop and his co-workers discovered the c-myc gene in the late 1970s (Bishop 1982), voluminous literature has documented its central role in proliferation and malignant transformation of human and animal cells (Amati et al. 1998, Bouchard et al. 1998, Dang et al. 1999). Most, if not all, types of human malignancy have been reported to have amplification and/or overexpression of this gene, although the frequency of these alterations varies greatly among different reports (Nesbit et al. 1999). In 1992, researchers started to realize that aberrant expression of c-myc could cause apoptosis (Evan et al. 1992, Shi et al. 1992), although the phenomenon had actually been observed much earlier (Wurm et al. 1986). Studies in recent years have further shown that the c-myc gene regulates growth, both in the sense of cell size and in the context of tissue differentiation (Gandarillas & Watt 1997, Iritani & Eisenman 1999, Johnston et al. 1999, Schmidt 1999, Schuhmacher et al. 1999). Thus, it is now known that the c-myc gene participates in most aspects of cellular function, including replication, growth, metabolism, differentiation, and apoptosis (Packham & Cleveland 1995, Hoffman & Liebermann 1998, Dang 1999, Dang et al. 1999, Elend & Eilers 1999, Prendergast 1999). How the c-Myc protein may be specifically directed to perform one, but not the others, of these functions is still obscure, despite the fact that the relevant literature has been accumulating at a fast pace in the past two decades. This review focuses on the profound roles of c-Myc in breast cancer and in the actions of the hormones that are eitologically related to breast cancer.

Free access
Maya Dadiani Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Search for other papers by Maya Dadiani in
Google Scholar
PubMed
Close
,
Dalia Seger Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Search for other papers by Dalia Seger in
Google Scholar
PubMed
Close
,
Tamar Kreizman Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Search for other papers by Tamar Kreizman in
Google Scholar
PubMed
Close
,
Daria Badikhi Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Search for other papers by Daria Badikhi in
Google Scholar
PubMed
Close
,
Raanan Margalit Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Search for other papers by Raanan Margalit in
Google Scholar
PubMed
Close
,
Raya Eilam Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Search for other papers by Raya Eilam in
Google Scholar
PubMed
Close
, and
Hadassa Degani Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Search for other papers by Hadassa Degani in
Google Scholar
PubMed
Close

’ regulator in breast cancer is the c-Myc proto-oncogene that encodes the c-Myc transcription factor. Estrogen has been shown to activate c-Myc expression in ERα-positive human breast cancer cells through its enhanced transcription ( Dubik & Shiu 1988

Free access
Alison J Butt
Search for other papers by Alison J Butt in
Google Scholar
PubMed
Close
,
Catriona M McNeil
Search for other papers by Catriona M McNeil in
Google Scholar
PubMed
Close
,
Elizabeth A Musgrove
Search for other papers by Elizabeth A Musgrove in
Google Scholar
PubMed
Close
, and
Robert L Sutherland
Search for other papers by Robert L Sutherland in
Google Scholar
PubMed
Close

increased c-Myc expression, which occurs within 15 min of oestrogen stimulation ( Dubik et al. 1987 , Dubik & Shiu 1988 ). The DNA binding region of ERα is required for c-Myc induction, and the P2 promoter region of the MYC gene contains an atypical ERE

Free access
D Dworakowska Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK
Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by D Dworakowska in
Google Scholar
PubMed
Close
,
E Wlodek Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by E Wlodek in
Google Scholar
PubMed
Close
,
C A Leontiou Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by C A Leontiou in
Google Scholar
PubMed
Close
,
S Igreja Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by S Igreja in
Google Scholar
PubMed
Close
,
M Cakir Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK
Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by M Cakir in
Google Scholar
PubMed
Close
,
M Teng Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by M Teng in
Google Scholar
PubMed
Close
,
N Prodromou Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by N Prodromou in
Google Scholar
PubMed
Close
,
M I Góth Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by M I Góth in
Google Scholar
PubMed
Close
,
S Grozinsky-Glasberg Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK
Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by S Grozinsky-Glasberg in
Google Scholar
PubMed
Close
,
M Gueorguiev Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by M Gueorguiev in
Google Scholar
PubMed
Close
,
B Kola Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by B Kola in
Google Scholar
PubMed
Close
,
M Korbonits Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by M Korbonits in
Google Scholar
PubMed
Close
, and
A B Grossman Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

Search for other papers by A B Grossman in
Google Scholar
PubMed
Close

phosphorylate ERK1 and ERK2 at two sites, Tyr185 followed by Thr183 ( Haystead et al . 1992 ). ERK1/2 in turn phosphorylates and activates ribosomal S6 kinase and transcription factors such as c-MYC, Elk1, c-Fos or CYCLIN D1 ( Terada et al . 1999 a , b

Free access
Gina Chia-Yi Chu Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Gina Chia-Yi Chu in
Google Scholar
PubMed
Close
,
Haiyen E Zhau Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Haiyen E Zhau in
Google Scholar
PubMed
Close
,
Ruoxiang Wang Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Ruoxiang Wang in
Google Scholar
PubMed
Close
,
André Rogatko Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by André Rogatko in
Google Scholar
PubMed
Close
,
Xu Feng Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Xu Feng in
Google Scholar
PubMed
Close
,
Majd Zayzafoon Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Majd Zayzafoon in
Google Scholar
PubMed
Close
,
Youhua Liu Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Youhua Liu in
Google Scholar
PubMed
Close
,
Mary C Farach-Carson Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Mary C Farach-Carson in
Google Scholar
PubMed
Close
,
Sungyong You Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Sungyong You in
Google Scholar
PubMed
Close
,
Jayoung Kim Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Jayoung Kim in
Google Scholar
PubMed
Close
,
Michael R Freeman Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Michael R Freeman in
Google Scholar
PubMed
Close
, and
Leland W K Chung Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

Search for other papers by Leland W K Chung in
Google Scholar
PubMed
Close

downstream c-Myc/Max or c-Met signaling network abolished skeletal metastasis in mice. Animal models also showed that RANKL-expressing PCa cells conferred bone colonizing and aggressive phenotypes to neighboring non-metastatic bystander cells by activating

Open access
Salma Kaochar Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Dan L. Duncan Comprehensive Cancer Center, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Salma Kaochar in
Google Scholar
PubMed
Close
,
Aleksandra Rusin Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Aleksandra Rusin in
Google Scholar
PubMed
Close
,
Christopher Foley Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Christopher Foley in
Google Scholar
PubMed
Close
,
Kimal Rajapakshe Dan L. Duncan Comprehensive Cancer Center, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Kimal Rajapakshe in
Google Scholar
PubMed
Close
,
Matthew Robertson Dan L. Duncan Comprehensive Cancer Center, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Matthew Robertson in
Google Scholar
PubMed
Close
,
Darlene Skapura Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Darlene Skapura in
Google Scholar
PubMed
Close
,
Cammy Mason Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Cammy Mason in
Google Scholar
PubMed
Close
,
Karen Berman De Ruiz Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Karen Berman De Ruiz in
Google Scholar
PubMed
Close
,
Alexey Mikhailovich Tyryshkin Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Alexey Mikhailovich Tyryshkin in
Google Scholar
PubMed
Close
,
Jenny Deng Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Jenny Deng in
Google Scholar
PubMed
Close
,
Jin Na Shin Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Jin Na Shin in
Google Scholar
PubMed
Close
,
Warren Fiskus Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Warren Fiskus in
Google Scholar
PubMed
Close
,
Jianrong Dong Dan L. Duncan Comprehensive Cancer Center, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Jianrong Dong in
Google Scholar
PubMed
Close
,
Shixia Huang Dan L. Duncan Comprehensive Cancer Center, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Department of Education, Innovation, and Technology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Shixia Huang in
Google Scholar
PubMed
Close
,
Nora M Navone Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Nora M Navone in
Google Scholar
PubMed
Close
,
Christel M Davis Avera Institute for Human Genetics, Sioux Falls, South Dakota, USA

Search for other papers by Christel M Davis in
Google Scholar
PubMed
Close
,
Erik A Ehli Avera Institute for Human Genetics, Sioux Falls, South Dakota, USA

Search for other papers by Erik A Ehli in
Google Scholar
PubMed
Close
,
Cristian Coarfa Dan L. Duncan Comprehensive Cancer Center, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Cristian Coarfa in
Google Scholar
PubMed
Close
, and
Nicholas Mitsiades Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Dan L. Duncan Comprehensive Cancer Center, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Nicholas Mitsiades in
Google Scholar
PubMed
Close

inhibit the GATA2 transcriptional program. Dilazep suppressed the expression of AR, c-MYC, FOXM1, CENPF, EZH2, and several other PC drivers. Using cellular thermal shift assay (CETSA), ChIP-qPCR, and GATA2 DNA-binding assay, we further confirmed GATA2

Open access
Céline Van Themsche Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Canada Research Chair in Molecular Gyneco-Oncology, Université du Québec à Trois-Rivières, 3351, Boul. des Forges, CP 500, Trois-Rivières, Québec, Canada G9A 5H7

Search for other papers by Céline Van Themsche in
Google Scholar
PubMed
Close
,
Sophie Parent Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Canada Research Chair in Molecular Gyneco-Oncology, Université du Québec à Trois-Rivières, 3351, Boul. des Forges, CP 500, Trois-Rivières, Québec, Canada G9A 5H7

Search for other papers by Sophie Parent in
Google Scholar
PubMed
Close
,
Valérie Leblanc Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Canada Research Chair in Molecular Gyneco-Oncology, Université du Québec à Trois-Rivières, 3351, Boul. des Forges, CP 500, Trois-Rivières, Québec, Canada G9A 5H7

Search for other papers by Valérie Leblanc in
Google Scholar
PubMed
Close
,
Caroline Descôteaux Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Canada Research Chair in Molecular Gyneco-Oncology, Université du Québec à Trois-Rivières, 3351, Boul. des Forges, CP 500, Trois-Rivières, Québec, Canada G9A 5H7

Search for other papers by Caroline Descôteaux in
Google Scholar
PubMed
Close
,
Anne-Marie Simard Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Canada Research Chair in Molecular Gyneco-Oncology, Université du Québec à Trois-Rivières, 3351, Boul. des Forges, CP 500, Trois-Rivières, Québec, Canada G9A 5H7

Search for other papers by Anne-Marie Simard in
Google Scholar
PubMed
Close
,
Gervais Bérubé Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Canada Research Chair in Molecular Gyneco-Oncology, Université du Québec à Trois-Rivières, 3351, Boul. des Forges, CP 500, Trois-Rivières, Québec, Canada G9A 5H7

Search for other papers by Gervais Bérubé in
Google Scholar
PubMed
Close
, and
Eric Asselin Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Canada Research Chair in Molecular Gyneco-Oncology, Université du Québec à Trois-Rivières, 3351, Boul. des Forges, CP 500, Trois-Rivières, Québec, Canada G9A 5H7

Search for other papers by Eric Asselin in
Google Scholar
PubMed
Close

′ (antisense) for c- myc ; 5′-CGGGCTTCAACGCAGACTA-3′ (sense) and 5′-GGTCCGTGCAGAAGTCCTG-3′ (antisense) for c- fos ; 5′-CAATGGCCACCATGGAGAAC-3′ (sense) and 5′-AACGGTGTCGTCGAAACAGC-3′ (antisense) for tff1 ; 5′-GTCAGTGGTGGACCTGACCT-3′ (sense) and 5

Free access
Stefan J Barfeld Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

Search for other papers by Stefan J Barfeld in
Google Scholar
PubMed
Close
,
Harri M Itkonen Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

Search for other papers by Harri M Itkonen in
Google Scholar
PubMed
Close
,
Alfonso Urbanucci Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

Search for other papers by Alfonso Urbanucci in
Google Scholar
PubMed
Close
, and
Ian G Mills Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway
Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway
Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

Search for other papers by Ian G Mills in
Google Scholar
PubMed
Close

, including c-Myc, which is overexpressed and predictive of poor prognosis in a subset of cases ( Hawksworth et al . 2010 ). Other examples include hypoxia-inducible factor 1α (HIF1A), which is associated with PCa metastasis ( Ranasinghe et al . 2013 ). In

Free access
Dong Hyun Seo Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Search for other papers by Dong Hyun Seo in
Google Scholar
PubMed
Close
,
Seul Gi Lee Yonsei University Graduate School of Medical Science, Seoul, South Korea

Search for other papers by Seul Gi Lee in
Google Scholar
PubMed
Close
,
Soon Min Choi Department of Surgery, Hallym Hospital, Incheon, South Korea

Search for other papers by Soon Min Choi in
Google Scholar
PubMed
Close
,
Ha Yan Kim Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, South Korea

Search for other papers by Ha Yan Kim in
Google Scholar
PubMed
Close
,
Sunmi Park Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Search for other papers by Sunmi Park in
Google Scholar
PubMed
Close
,
Sang Geun Jung Department of Gynecological Oncology, Bundang CHA Medical Center, CHA University Gyeonggi-do, South Korea

Search for other papers by Sang Geun Jung in
Google Scholar
PubMed
Close
,
Young Suk Jo Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Search for other papers by Young Suk Jo in
Google Scholar
PubMed
Close
, and
Jandee Lee Department of Surgery, Open NBI Convergence Technology Research Laboratory, Yonsei University College of Medicine, Seoul, South Korea

Search for other papers by Jandee Lee in
Google Scholar
PubMed
Close

Figure 3C). MYC , NFκB 2, and V-Rel avian reticuloendotheliosis viral oncogene homolog B ( RELB ) were upregulated in TERT (+) PTC ( Fig. 1F ; Supplementary Figure 3D). Furthermore, the expression levels of TERT were significantly correlated with

Restricted access