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Walid Zeyghami
Walid Zeyghami
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Marie-Louise Uhre Hansen
Marie-Louise Uhre Hansen
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Kathrine Kronberg Jakobsen
Kathrine Kronberg Jakobsen
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Christian Groenhøj
Christian Groenhøj
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Endocrinology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark
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Christian von Buchwald
Christian von Buchwald
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark
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Christoffer Holst Hahn
Christoffer Holst Hahn
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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released from the primary tumors such as circulating tumor cells (CTCs) or cell-free DNA (cfDNA) ( Fig. 1 ). Several techniques have been developed to detect liquid biopsies ( Palmirotta et al. 2018 , Lone et al. 2022 ). The increased release of cfDNA
Maria Chiara Zatelli
Maria Chiara Zatelli
Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy
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Erika Maria Grossrubatscher
Erika Maria Grossrubatscher
Endocrine Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
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Elia Guadagno
Elia Guadagno
Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy
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Concetta Sciammarella
Concetta Sciammarella
IOS & COLEMAN Srl, Naples, Italy
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Antongiulio Faggiano
Antongiulio Faggiano
Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura Dei Tumori ‘Fondazione G. Pascale’ – IRCCS, Naples, Italy
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Annamaria Colao
Annamaria Colao
IOS & COLEMAN Srl, Naples, Italy
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performed in cancer fields different from NENs. Aim The aim of this review is to summarize the available data on two new putative prognostic biomarkers for NENs, such as circulating tumors cells (CTCs) and microRNAs (miRNAs). Methods Among
Nely Díaz-Mejía
Nely Díaz-Mejía
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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David García-Illescas
David García-Illescas
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Rafael Morales-Barrera
Rafael Morales-Barrera
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Cristina Suarez
Cristina Suarez
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Jacques Planas
Jacques Planas
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Xavier Maldonado
Xavier Maldonado
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Joan Carles
Joan Carles
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Joaquin Mateo
Joaquin Mateo
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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evaluated the response to olaparib among 49 men with mCRPC, defining response as either a radiological response according to RECIST, a PSA response >50% and/or a confirmed circulating tumor cells (CTC) count conversion from high to low counts. Overall, 33
Mark Daniel
Mark Daniel
Masonic Cancer Center, University of Minnesota
Graduate Program in Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, Minnesota, USA
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Graduate Program in Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, Minnesota, USA
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Todd P Knutson
Todd P Knutson
University of Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, USA
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Jamie M Sperger
Jamie M Sperger
Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Yingming Li
Yingming Li
Masonic Cancer Center, University of Minnesota
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Anupama Singh
Anupama Singh
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Charlotte N Stahlfeld
Charlotte N Stahlfeld
Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Courtney Passow
Courtney Passow
University of Minnesota Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA
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Benjamin Auch
Benjamin Auch
University of Minnesota Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA
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Joshua M Lang
Joshua M Lang
Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Scott M Dehm
Scott M Dehm
Masonic Cancer Center, University of Minnesota
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA
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Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA
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are challenging and a high burden for patients. As a result, assessing CRPC genomic alterations via blood-based 'liquid biopsy' is an attractive alternative. One common liquid biopsy approach involves the examination of circulating tumor cells (CTCs
Alexa Childs
Alexa Childs
UCL Cancer Institute, University College London, London, UK
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Christopher D Steele
Christopher D Steele
UCL Cancer Institute, University College London, London, UK
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Clare Vesely
Clare Vesely
UCL Cancer Institute, University College London, London, UK
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Francesca M Rizzo
Francesca M Rizzo
UCL Cancer Institute, University College London, London, UK
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Leah Ensell
Leah Ensell
UCL Cancer Institute, University College London, London, UK
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Helen Lowe
Helen Lowe
UCL Cancer Institute, University College London, London, UK
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Pawan Dhami
Pawan Dhami
UCL Cancer Institute, University College London, London, UK
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Heli Vaikkinen
Heli Vaikkinen
UCL Cancer Institute, University College London, London, UK
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Tu Vinh Luong
Tu Vinh Luong
Department of Histopathology, Royal Free London NHS Foundation Trust, London, UK
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Lucia Conde
Lucia Conde
UCL Cancer Institute, University College London, London, UK
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Javier Herrero
Javier Herrero
UCL Cancer Institute, University College London, London, UK
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Martyn Caplin
Martyn Caplin
Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK
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Christos Toumpanakis
Christos Toumpanakis
Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK
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Christina Thirlwell
Christina Thirlwell
UCL Cancer Institute, University College London, London, UK
Department of Oncology, Royal Free London NHS Foundation Trust, London, UK
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Department of Oncology, Royal Free London NHS Foundation Trust, London, UK
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John A Hartley
John A Hartley
UCL Cancer Institute, University College London, London, UK
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Nischalan Pillay
Nischalan Pillay
Research Department of Pathology, Cancer Institute, University College London, London, UK
Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK
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Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK
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Tim Meyer
Tim Meyer
UCL Cancer Institute, University College London, London, UK
Department of Oncology, Royal Free London NHS Foundation Trust, London, UK
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Department of Oncology, Royal Free London NHS Foundation Trust, London, UK
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. Furthermore, characterization of single-circulating tumor cells (CTCs) as part of a minimally invasive 'liquid biopsy' provides an opportunity to explore tumor biology and identify therapeutic targets. The first clinical applications of CTCs focused on
Courtney A Dreyer
Courtney A Dreyer
Department of Biochemistry and Molecular Medicine, and UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, USA
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Kacey VanderVorst
Kacey VanderVorst
Department of Biochemistry and Molecular Medicine, and UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, USA
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Savannah Free
Savannah Free
Department of Biochemistry and Molecular Medicine, and UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, USA
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Ashley Rowson-Hodel
Ashley Rowson-Hodel
Department of Biochemistry and Molecular Medicine, and UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, USA
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Kermit L Carraway III
Kermit L Carraway III
Department of Biochemistry and Molecular Medicine, and UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, USA
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), and association with cells in circulation ( Lambert et al. 2017 ). Important intermediaries of the distant metastatic cascade are circulating tumor cells (CTCs), which exit primary tumors as single cells or clusters and travel to distant sites to
Laura Gerard
Laura Gerard
Service de Gastroentérologie et d’Oncologie Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Céline Patte
Céline Patte
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Laurence Chardon
Laurence Chardon
Service de Biochimie Biologie Moléculaire, Centre de Biologie Est, Hospices Civils de Lyon, Bron, France
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Valérie Hervieu
Valérie Hervieu
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
Service Central d’Anatomie et Cytologie Pathologiques, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Service Central d’Anatomie et Cytologie Pathologiques, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Léa Payen
Léa Payen
Institut de Cancérologie des Hospices Civils de Lyon, CIRculating CANcer Program (CIRCAN), Lyon, France
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Marion Allio
Marion Allio
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Claire Marx
Claire Marx
Service d'Endocrinologie-Diabète-Nutrition, Hospices Civils de Lyon, Hôpital Lyon Sud, Lyon, France
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Hugo Clermidy
Hugo Clermidy
Service de Chirurgie Thoracique, Vidéothoracoscopie et Transplantation Pulmonaire, Hospices Civils de Lyon, Hôpital Louis Pradel, Lyon, France
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Alice Durand
Alice Durand
Service de Gastroentérologie et d’Oncologie Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Patrick Mehlen
Patrick Mehlen
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Julien Bollard
Julien Bollard
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Gilles Poncet
Gilles Poncet
Service de Chirurgie Digestive, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Colette Roche
Colette Roche
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Benjamin Gibert
Benjamin Gibert
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Thomas Walter
Thomas Walter
Service de Gastroentérologie et d’Oncologie Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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have emerged as a non-invasive and repeatable alternative during disease course. Circulating tumour cells (CTCs) are tumour cells that have shed from the primary tumour and extravasated into the bloodstream ( Garcia et al. 2019 , Mandair et al
J Hadoux
J Hadoux
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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D Malka
D Malka
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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D Planchard
D Planchard
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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J Y Scoazec
J Y Scoazec
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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C Caramella
C Caramella
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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J Guigay
J Guigay
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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V Boige
V Boige
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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S Leboulleux
S Leboulleux
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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P Burtin
P Burtin
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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A Berdelou
A Berdelou
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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Y Loriot
Y Loriot
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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P Duvillard
P Duvillard
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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C N Chougnet
C N Chougnet
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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D Déandréis
D Déandréis
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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M Schlumberger
M Schlumberger
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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I Borget
I Borget
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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M Ducreux
M Ducreux
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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E Baudin
E Baudin
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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treatment and response to first-line cisplatin–etoposide combination, date of FOLFOX initiation, schedules of chemotherapy, number of cycles administered, toxicity according to the National Cancer Institute Common Terminology Criteria (NCI-CTC) v.4.0, dose
D Mandair
D Mandair
UCL Cancer Institute, University College London, London, UK
Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK
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Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK
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C Vesely
C Vesely
UCL Cancer Institute, University College London, London, UK
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L Ensell
L Ensell
UCL Cancer Institute, University College London, London, UK
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H Lowe
H Lowe
UCL Cancer Institute, University College London, London, UK
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V Spanswick
V Spanswick
UCL Cancer Institute, University College London, London, UK
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J A Hartley
J A Hartley
UCL Cancer Institute, University College London, London, UK
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M E Caplin
M E Caplin
Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK
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T Meyer
T Meyer
UCL Cancer Institute, University College London, London, UK
Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK
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Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK
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Dear Editor, Circulating tumour cells (CTCs) have been hypothesised to be mediators of metastases ( Fidler et al . 2003 ) but with numbers as low as 1/10 7 white cells ( Alunni-Fabbroni & Sandri 2010 ), their utility as biomarkers has been
Sathya Neelature Sriramareddy
Sathya Neelature Sriramareddy
Molecular and Cellular Epigenetics (GIGA), University of Liege, Liège, Belgium
Molecular Biology (TERRA), University of Liege, Gembloux, Belgium
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Molecular Biology (TERRA), University of Liege, Gembloux, Belgium
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Etienne Hamoir
Etienne Hamoir
Endocrinology, University Hospital, Liège, Belgium
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Marcela Chavez
Marcela Chavez
Clinical Hematology, University Hospital, Liège, Belgium
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Renaud Louis
Renaud Louis
Pneumology, University Hospital, Liège, Belgium
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Albert Beckers
Albert Beckers
Endocrinology, University Hospital, Liège, Belgium
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Luc Willems
Luc Willems
Molecular and Cellular Epigenetics (GIGA), University of Liege, Liège, Belgium
Molecular Biology (TERRA), University of Liege, Gembloux, Belgium
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Molecular Biology (TERRA), University of Liege, Gembloux, Belgium
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despite metastasis of rare tumor cells in thyroidectomized patients. In this context, we designed a sensitive and specific technique to identify calcitonin-positive circulating tumor cells (CTC) in medullary thyroid carcinoma. We demonstrate that
