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William D Foulkes, Jérôme Bertherat, and Charis Eng

significantly affect management at each stage – prevention, diagnosis and treatment. These reviews are focused on these aspects. If we are going to start with a gene that is associated with an endocrine syndrome, let’s start with PTEN , as the Editor

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L Fishbein, S Ben-Maimon, S Keefe, K Cengel, D A Pryma, A Loaiza-Bonilla, D L Fraker, K L Nathanson, and D L Cohen

Dear Editor, Pheochromocytomas and paragangliomas (PCCs/PGLs) are tumors in the adrenal medulla and extra-adrenal ganglia, respectively. About a quarter are metastatic, often with a long latency period. Some PCC/PGLs are defined as clinically

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Simone De Leo, Michela Perrino, Sara Badiali, Stefania Rossi, Valentina Cirello, Carla Colombo, Delfina Tosi, Gianmaria Cantoni, Luca Poggi, Gaetano Bulfamante, Paolo Beck-Peccoz, Leonardo Vicentini, and Laura Fugazzola

Dear Editor Incidental thyroid carcinoma (ITC) is defined as a tumor diagnosed at histology after surgical intervention for a benign thyroid disease and, therefore, without a preoperative diagnosis of malignancy. The prevalence of ITCs reported in

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Zi Ying Tan, Taosheng Huang, and Joanne Ngeow

base editor (ABE) has been reported to mediate conversion of A:T to C:G base pairing in genomic DNA without DSBs ( Gaudelli et al. 2017 ) ( Fig. 2B ). In this massive effort to evolve tRNA adenine deaminase (TadA) for seven generations in bacteria

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Kristien Boelaert

diseases as well as the patient interaction during the clinical years of study, which affirmed my feeling that I had made the right career choice. In 1993, during my 6th year of study, I was given the unique opportunity of participating in an Erasmus

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Francesca Marini, Francesca Giusti, Francesco Tonelli, and Maria Luisa Brandi

before the age of 5 years. A positive MEN1 genetic test is indication for periodic biochemical and imaging screenings for MEN1-associated tumor detection, and for the early choice of the appropriate surgical and/or pharmacological treatment

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Roberta Visconti and Domenico Grieco

screening and diagnosis have allowed detection of the disease in early stages in approximately 85% of cases. Radical prostatectomy, radiation therapy and active surveillance are treatments of choice for early, organ-confined tumors that can be cured in the

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Frédéric Castinetti, Alexander Kroiss, Rakesh Kumar, Karel Pacak, and David Taieb

approaches for PHEOs/PGLs according to the localization and genotype Entities Associated conditions 1st choice radiopharmaceuticals 2nd choice radiopharmaceuticals PHEO MEN2 (RET), SDHx, VHL, NF1, TMEM127, MAX 18 F-FDOPA 123 I-MIBG Extraadrenal abdominal and

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Hannah Nieto and Kristien Boelaert

, follicular carcinoma is defined as a tumour that invades the capsule, a feature that cannot be identified on cytological evaluation rendering these cancers indistinguishable from thyroid adenomas using cytopathology. The standard treatment of choice is

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Amélie Fradet-Turcotte, Justine Sitz, Damien Grapton, and Alexandre Orthwein

( Fig. 3 ). DNA repair pathway choice is controlled in mammalian cells by the tumor suppressors p53-binding protein 1 (53BP1) and BRCA1, which have an antagonistic relationship ( Chapman et al . 2012 , Escribano-Diaz et al . 2013 , Tang et al . 2013