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Cristina L Ronchi
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Silviu Sbiera Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany

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Barbara Altieri
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Sonja Steinhauer
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Vanessa Wild Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany
Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany

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Michaela Bekteshi
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Matthias Kroiss Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany

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Martin Fassnacht
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Bruno Allolio
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localization sequence (NICD), an RBP-Jκ-associated module (RAM) domain, a C-terminal PEST region, and seven ankyrin repeats. Up until now, four receptors (NOTCH1, NOTCH2, NOTCH3, and NOTCH4) and six ligands (JAG1, JAG2, DLL1, DLL3, DLL4, and DLK1) have been

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0163
Volume/Issue:
Volume 22: Issue 4
Free access
Hongyu Chen Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Dan Liu Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Zhengyan Yang Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Limin Sun Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Que Deng Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Shuo Yang Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Lu Qian Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Liang Guo Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Ming Yu Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Meiru Hu Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Ming Shi Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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Ning Guo Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China

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degree of angiogenesis in vitro , were counted in five random low-power fields. Construction JAG1 cDNA was amplified from the total RNA of MDA-231 cells by RT-PCR using the specific primers (sense: 5′-CCGGAATTCAGCACCAGCGCGAACAGCAG-3′ and antisense: 5

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0236
Volume/Issue:
Volume 21: Issue 5
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Antonella Verrienti Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Giovanni Tallini Department of Medicine (DIMES), Anatomic Pathology-Molecular Diagnostic Unit AUSL of Bologna, University of Bologna School of Medicine, Bologna, Italy

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Chiara Colato Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy

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Amélie Boichard Laboratoire de Recherche Translationnelle et, Centre de Ressources Biologiques, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France

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Saula Checquolo Laboratory of Molecular Pathology, Department of Medico-Surgical and Biotechnology, ‘Sapienza’ University of Rome, Latin, Italy

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Valeria Pecce Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Marialuisa Sponziello Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Francesca Rosignolo Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Dario de Biase Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, Bologna, Italy

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Kerry Rhoden Department of Medicine (DIMEC), Medical Genetics Unit, University of Bologna School of Medicine, Bologna, Italy

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Gian Piero Casadei Anatomic Pathology Unit, AUSL di Bologna-Maggiore Hospital, Bologna, Italy

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Diego Russo Department of Health Sciences, University of Catanzaro ‘Magna Graecia’, Catanzaro, Italy

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Michela Visani Department of Medicine (DIMES), Anatomic Pathology-Molecular Diagnostic Unit AUSL of Bologna, University of Bologna School of Medicine, Bologna, Italy

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Giorgia Acquaviva Department of Medicine (DIMES), Anatomic Pathology-Molecular Diagnostic Unit AUSL of Bologna, University of Bologna School of Medicine, Bologna, Italy

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Marco Ferdeghini Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy

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Sebastiano Filetti Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Cosimo Durante Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Scientific) for the main components of the Notch pathway (receptors: NOTCH1, 2, 3, 4 ; ligands: DLL1, DLL3, DLL4, JAG1, JAG2 ; regulators: the gamma-secretases PSEN1 and 2 , DTX1, MAML1 and RBPJ ; effectors: HES1, HEY1-2-L; the repressor NUMB

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0132
Volume/Issue:
Volume 23: Issue 8
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Garrett Daniels Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Yirong Li Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Lan Lin Gellert Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Albert Zhou Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Jonathan Melamed Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Xinyu Wu Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Xinming Zhang Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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David Zhang Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Daniel Meruelo Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Susan K Logan Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Ross Basch Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Peng Lee Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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GAPDH (Cell Signaling (Danvers, MA, USA)), KRT18, NKX3-1, p21, p27, HUS1, and JAG1 (Abcam (Cambridge, MA, USA)). Immunofluorescence microscopy The cells were fixed in 4% paraformaldehyde (PFA) for 20 min and permeabilized in 1:1 methanol:acetone for 20

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0293
Volume/Issue:
Volume 21: Issue 1
Free access
V Häyry Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

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K Salmenkivi Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

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J Arola Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

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P Heikkilä Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

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C Haglund Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

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H Sariola Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

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Introduction Phaeochromocytoma is a rare tumour of the adrenal medulla. We lack exact incidence figures in Finland, but in Sweden, the incidence is 2.1 per million ( Stenstrom & Svardsudd 1986 ). It usually arises from adrenergic cells in the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0049
Volume/Issue:
Volume 16: Issue 4
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Yu-fang Bi Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Rui-xin Liu Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Lei Ye Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Hai Fang Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Xiao-ying Li Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases
Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Wei-qing Wang Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Ji Zhang Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Kan-Kan Wang Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Lei Jiang Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Ting-wei Su Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Zhong-yuan Chen Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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Guang Ning Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases
Department of Endocrinology and Metabolism, State Key Laboratory of Medical Genomics, Department of Thoracic Surgery, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases

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.56 0.01 NM_016645 NEUGRIN 1.31 1.58 1.49 1.62 0.51 0.73 0.01 NM_000214 JAG1 1.11 1.10 −0.37 1.10 1.71 1.66 0.13 AB044088 BHLHB3 1.08 0.46 1.35 1.28 0.27 0.91 0.24 NM_001242 TNFRSF7 −1.11 0.12 −1.31 0.02 −0.92 −0.81 0.24 AF208043 IFI16 −1.17 0.33 −1

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Research Article
DOI:
https://doi.org/10.1677/ERC-08-0325
Volume/Issue:
Volume 16: Issue 4
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Marc Lacroix
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additional immunotherapy targets, such as NY-ESO-1 ( Sugita et al. 2004 , Jäger and Knuth 2005 ), as standard cytotoxic chemotherapy is inefficient in non-proliferating DTC. Table 1 A list of markers that have been used in mono- or multi

Article Type:
Review Article
DOI:
https://doi.org/10.1677/ERC-06-0001
Volume/Issue:
Volume 13: Issue 4
Free access
Lautaro Zubeldía-Brenner Instituto de Biología y Medicina Experimental, IBYME-CONICET, Buenos Aires, Argentina

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Catalina De Winne Instituto de Biología y Medicina Experimental, IBYME-CONICET, Buenos Aires, Argentina

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Sofía Perrone Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires, CITNOBA (UNNOBA-CONICET), Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Buenos Aires, Argentina

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Santiago A Rodríguez-Seguí Departamento de Fisiología y Biología Molecular y Celular, Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina
CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina

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Christophe Willems Department of Development and Regeneration, Cluster Stem Cell and Developmental Biology, Unit of Stem Cell Research, KU Leuven (University of Leuven), Leuven, Belgium

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Ana María Ornstein Instituto de Biología y Medicina Experimental, IBYME-CONICET, Buenos Aires, Argentina

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Isabel Lacau-Mengido Instituto de Biología y Medicina Experimental, IBYME-CONICET, Buenos Aires, Argentina

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Hugo Vankelecom Department of Development and Regeneration, Cluster Stem Cell and Developmental Biology, Unit of Stem Cell Research, KU Leuven (University of Leuven), Leuven, Belgium

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Carolina Cristina Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires, CITNOBA (UNNOBA-CONICET), Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Buenos Aires, Argentina

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Damasia Becu-Villalobos Instituto de Biología y Medicina Experimental, IBYME-CONICET, Buenos Aires, Argentina

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two subunits: an extracelluar and an intracelluar domain (NICD) held together by non-covalent interactions. Notch signaling is initiated by cell-to-cell contact of the receptor with the neighboring-cell Notch ligands Jagged1 and 2 (JAG1 and JAG2) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0337
Volume/Issue:
Volume 26: Issue 1
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Serk In Park Department of Periodontics and Oral Medicine, Department of Pathology, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, Michigan 48109, USA

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Laurie K McCauley Department of Periodontics and Oral Medicine, Department of Pathology, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, Michigan 48109, USA
Department of Periodontics and Oral Medicine, Department of Pathology, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, Michigan 48109, USA

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fewer metastatic lesions compared to cells expressing higher PTHrP, potentially mediated by increased anoikis due to loss of intracrine PTHrP activity. Materials and methods Cells PC-3, LNCaP, and Ace-1 prostate carcinoma cells were selected to study the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0278
Volume/Issue:
Volume 19: Issue 3
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Annu Makker Post Graduate Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

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Madhu Mati Goel Post Graduate Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

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between SHARP1 and E-cadherin levels; negative correlation between SHARP1 and vimentin, SNAIL and JAG1 Tumor samples ( n =15); Ishikawa and HEC1B cell lines Liao et al . (2014 b ) Notch pathway has a tumor-suppressive role in human EC cells Tumor (stage 1

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0218
Volume/Issue:
Volume 23: Issue 2
Free access