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Zhaoxia Zhang, Sasha Beyer, and Sissy M Jhiang

and monitoring of recurrence and metastases as well as alternative targeted therapy with minimal side effects for breast cancer patients remains warranted. The Na + /I − symporter (NIS (SLC5A5)) is a transmembrane glycoprotein that mediates active

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Aparna Lakshmanan, Anna Wojcicka, Marta Kotlarek, Xiaoli Zhang, Krystian Jazdzewski, and Sissy M Jhiang

Introduction Na + /I − symporter (NIS)-mediated radioiodide uptake (RAIU) in thyroid cells allows for targeted treatment of thyroid cancer. Many patients with advanced thyroid cancer do not benefit from radioiodine therapy due to reduced

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Zongjing Zhang, Dingxie Liu, Avaniyapuram Kannan Murugan, Zhimin Liu, and Mingzhao Xing

with decreased or lost expression of thyroid iodide-handling genes in PTC, particularly sodium iodide symporter (NIS; Xing 2007 a , Kim et al . 2012 , Xing et al . 2013 a ), which is normally localized in the basal membrane of thyroid cells and

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Christina Schug, Sarah Urnauer, Carsten Jaeckel, Kathrin A Schmohl, Mariella Tutter, Katja Steiger, Nathalie Schwenk, Markus Schwaiger, Ernst Wagner, Peter J Nelson, and Christine Spitzweg

MSCs as a tool to deliver therapeutic genes, such as the sodium iodide symporter ( NIS ), deep into tumor microenvironments ( Hagenhoff et al. 2016 , Melzer et al. 2016 ). NIS is an intrinsic transmembrane glycoprotein with 13 putative

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Camille Buffet, Johanna Wassermann, Fabio Hecht, Laurence Leenhardt, Corinne Dupuy, Lionel Groussin, and Charlotte Lussey-Lepoutre

membrane of normal and tumoral thyroid epithelial cells of a symporter, the sodium iodide symporter (NIS), that transports two sodium ions and one iodide ion into the cytosol. Iodide is then handled by an iodine-metabolizing machinery that concentrates

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Garcilaso Riesco-Eizaguirre, Pilar Santisteban, and Antonio De la Vieja

characterized ( Dai et al. 1996 ). Nancy Carrasco’s group demonstrated that a sodium/iodide symporter (NIS) actively transports two ions of sodium along with one of iodide into the cells using the favorable gradient of Na + . NIS is localized in the

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C Spitzweg, P J Nelson, E Wagner, P Bartenstein, W A Weber, M Schwaiger, and J C Morris

Introduction Based on its well-characterized role in radioiodine imaging and therapy in differentiated thyroid cancer, the sodium iodide symporter (NIS) represents one of the oldest targets for molecular imaging and targeted radionuclide

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Wei Li and Kenneth B Ain

, suggesting the presence of a trans -acting repressor of hNIS transcription, termed NIS-repressor ( Li et al . 2007 ). Multiple cellular and nuclear factors are reported to be important for NIS transcription, including thyrotropin (TSH)/receptor ( Riedel et

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Marie-Claude Hofmann, Muthusamy Kunnimalaiyaan, Jennifer R Wang, Naifa L Busaidy, Steven I Sherman, Stephen Y Lai, Mark Zafereo, and Maria E Cabanillas

, immunotherapy can be used as an effective therapy to improve the benefits of kinase inhibitors ( Iyer et al. 2018 ). Redifferentiation therapies The uptake of iodine by thyroid follicular cells is mediated by a sodium iodide symporter (NIS) located in

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Yu-Yu Liu, Xiaoli Zhang, Matthew D Ringel, and Sissy M Jhiang

Introduction The Na + /I − symporter (NIS) is a transmembrane glycoprotein that is expressed on the basolateral membrane of thyroid follicular cells. NIS-mediated iodide uptake from the circulating bloodstream into the thyroid follicular cells is