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Meng Ji Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Yanli Yao Glycochemistry & Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Shanghai, China
University of the Chinese Academy of Sciences, Beijing, China

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Anan Liu Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Ligang Shi Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Danlei Chen Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Liang Tang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Guang Yang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Xing Liang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Junfeng Peng Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Chenghao Shao Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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overexpressed in pNEN tissues and was positively correlated with H19 expression to promote cancer progression. Moreover, higher VGF expression was markedly related to poor differentiation and advanced stage. RNA sequence analysis revealed that H19 activates PI3K/Akt/CREB

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Meng Ji Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Yanli Yao Glycochemistry & Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Shanghai, China
University of the Chinese Academy of Sciences, Beijing, China

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Anan Liu Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Ligang Shi Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Danlei Chen Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Liang Tang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Guang Yang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Xing Liang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Junfeng Peng Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Chenghao Shao Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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knockdown efficiencies were verified by qPCR assay. CT represents cell transfection with control lentivirus; 1A, 2A and 3A represent cells transfected with three kinds of H19 shRNA lentiviruses. (C, D and E) Proliferation of H19-knockdown and control QGP-1

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Xin Qiu Department of Obstetrics and Gynaecology Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4

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Jung-Chien Cheng Department of Obstetrics and Gynaecology Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4

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Hsun-Ming Chang Department of Obstetrics and Gynaecology Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4

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Peter C K Leung Department of Obstetrics and Gynaecology Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4

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phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway. Moreover, inhibition of COX2 and PGE2 attenuates EGF-induced cancer cell invasion. These results demonstrate that COX2 and PGE2 are involved in EGF-induced human ovarian cancer cell invasion. Materials and

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Kathrin Zitzmann Department of Internal Medicine II, Institute of Molecular Animal Breeding and Biotechnology, University‐Hospital Munich-Grosshadern, Munich, Germany

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George Vlotides Department of Internal Medicine II, Institute of Molecular Animal Breeding and Biotechnology, University‐Hospital Munich-Grosshadern, Munich, Germany

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Stephan Brand Department of Internal Medicine II, Institute of Molecular Animal Breeding and Biotechnology, University‐Hospital Munich-Grosshadern, Munich, Germany

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Harald Lahm Department of Internal Medicine II, Institute of Molecular Animal Breeding and Biotechnology, University‐Hospital Munich-Grosshadern, Munich, Germany

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Gerald Spöttl Department of Internal Medicine II, Institute of Molecular Animal Breeding and Biotechnology, University‐Hospital Munich-Grosshadern, Munich, Germany

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Burkhard Göke Department of Internal Medicine II, Institute of Molecular Animal Breeding and Biotechnology, University‐Hospital Munich-Grosshadern, Munich, Germany

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Christoph J Auernhammer Department of Internal Medicine II, Institute of Molecular Animal Breeding and Biotechnology, University‐Hospital Munich-Grosshadern, Munich, Germany

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with mTOR inhibitors, direct Akt inhibition with perifosine appears to have a more broad inhibitory effect on the PI(3)K–Akt–mTOR pathway without compensatory activation of PI(3)K and ERK1/2 signaling. On the other hand, perifosine induced CREB and JNK

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M Muşat
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M Korbonits
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B Kola
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N Borboli
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M R Hanson
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A M Nanzer
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J Grigson
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S Jordan
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D G Morris
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M Gueorguiev
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M Coculescu
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S Basuand
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A B Grossman
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). The serine/threonine protein kinase PKB/Akt has emerged as a crucial regulator of growth, proliferation, differentiation and apoptosis, and is a major downstream effector of PI3K. Three isoforms of Akt (Akt1, Akt2, Akt3) have been cloned that are in

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M Bullock Hormones and Cancer Group, Cancer Genetics Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital, Pacific Highway Saint Leonards, Sydney, New South Wales 2065, Australia

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is a key feature of breast cancer cells transformed by oncogenic PI3K–AKT signaling ( Zhang et al . 2011 , Fig. 1 ). It is also becoming clear that aberrant FOXO activity promotes a number of characteristic features of hormone-independent breast

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Carl Weidinger Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Kerstin Krause Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Antje Klagge Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Stefan Karger Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Dagmar Fuhrer Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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. For instance, activation of the PI3K/Akt pathway results in an active export of FOXOs into the cytoplasm. By contrast, in response to stress, FOXOs are activated by the members of the c-Jun-N-terminal kinase (JNK) leading to nuclear FOXO accumulation

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Yan Huang Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China
Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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Hongyan Jin Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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Yingtao Liu Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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Jiayi Zhou Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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Jingxin Ding Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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Kwai Wa Cheng Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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Yinhua Yu Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China
Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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Youji Feng Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China
Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China

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(A) SKOV-3 cells and (B) ES-2 cells with different kinetics but did not affect pCREB and pIκB expression. The molecules pAKT, AKT, pJUN, cJUN, pCREB, CREB, pIκB, and IκB were detected by western blot. (C and D) The PI3K/AKT inhibitor LY294002 (LY) and

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Dannah R Miller Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA

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Matthew A Ingersoll Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA

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Ming-Fong Lin Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
Section of Urology, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

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benign cell lines, and induction of miR-331-3p in cancer cells suppresses tumor phenotype through inhibition of PI3K/AKT signaling ( Epis et al. 2009 ). Interestingly, human antigen R (HuR) is an RNA-binding protein with elevated levels in PCa, which

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Daniela Regazzo Department of Medicine – Endocrinology Unit, Padova University Hospital, Padova, Italy

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Loris Bertazza Department of Medicine – Endocrinology Unit, Padova University Hospital, Padova, Italy

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Eva Galletta Department of Biology, University of Padova, Padova, Italy

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Susi Barollo Department of Medicine – Endocrinology Unit, Padova University Hospital, Padova, Italy

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Alberto Mondin Department of Medicine – Endocrinology Unit, Padova University Hospital, Padova, Italy

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Stefania Zovato Hereditary Tumors Unit, Veneto Institute of Oncology-IOV-IRCCS, Padova, Italy

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Maurizio Iacobone Department of Surgery, Oncology and Gastroenterology – Endocrine Surgery Unit, Padova University Hospital, Padova, Italy

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Eleonora Zilio Department of Biology, University of Padova, Padova, Italy

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Carla Scaroni Department of Medicine – Endocrinology Unit, Padova University Hospital, Padova, Italy

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Claudia Maria Radu Department of Medicine – General Medicine and Thrombotic and Haemorrhagic Diseases Unit, Padova University Hospital, Padova, Italy

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Giulietta di Benedetto Neuroscience Institute, National Research Council, Padova Section, Padova, Italy
Foundation for Advanced Biomedical Research, Veneto Institute of Molecular Medicine (VIMM), Padova, Italy

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Caterina Mian Department of Medicine – Endocrinology Unit, Padova University Hospital, Padova, Italy

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Konstantinos Lefkimmiatis Foundation for Advanced Biomedical Research, Veneto Institute of Molecular Medicine (VIMM), Padova, Italy
Department of Molecular Medicine, University of Pavia, Pavia, Italy

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Gianluca Occhi Department of Biology, University of Padova, Padova, Italy

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) and PI3K-PKB/Akt ( Widenmaier et al. 2009 , Prabakaran et al. 2010 , Yabe & Seino 2011 ) or by reducing caspase 3 activity as well as the expression of the pro-apoptotic bax gene through a Foxo1 indirect effect (revised in Seino et al. 2010

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