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Kristen Wong
Kristen Wong
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
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Francesca Di Cristofano
Francesca Di Cristofano
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
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Michela Ranieri
Michela Ranieri
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
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Daniela De Martino
Daniela De Martino
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
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Antonio Di Cristofano
Antonio Di Cristofano
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
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the cell cycle into the S phase is controlled by complexes formed by D-type cyclins and the CDK4 and CDK6 kinases, which phosphorylate and inactivate the RB tumor suppressor. In turn, RB inactivation releases the E2F transcription factors to promote
Chellappagounder Thangavel
Chellappagounder Thangavel
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Jeffry L Dean
Jeffry L Dean
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Adam Ertel
Adam Ertel
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Karen E Knudsen
Karen E Knudsen
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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C Marcelo Aldaz
C Marcelo Aldaz
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Agnieszka K Witkiewicz
Agnieszka K Witkiewicz
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Robert Clarke
Robert Clarke
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Erik S Knudsen
Erik S Knudsen
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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Kimmel Cancer Center, Cancer Biology, Pathology, Department of Carcinogenesis, Lombardi Cancer Center, Department of Oncology and Physiology and Biophysics, Philadelphia, Pennsylvania 19107, USA Departments of
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such, inhibition of CDK activity results in the maintenance of the retinoblastoma tumor suppressor protein (RB) in a hypophosphorylated and active state ( Watts et al . 1995 ). In its hypophosphorylated state, RB serves to repress E2F-regulated genes
Toru Tateno
Toru Tateno
Department of Medicine, The Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
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Tae Nakano-Tateno
Tae Nakano-Tateno
Department of Medicine, The Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
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Shereen Ezzat
Shereen Ezzat
Department of Medicine, The Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
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Sylvia L Asa
Sylvia L Asa
Department of Pathology, The Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
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, the sustentacular cells of the adenohypophysis, yet our data unmask a novel dispensable role for Rb in those cells. Materials and methods Generation of constitutive NG2 cell-specific pRb conditional knockout mice For constitutive deletion
Roeliene C Kruizinga
Roeliene C Kruizinga
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Wim J Sluiter
Wim J Sluiter
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Elisabeth G E de Vries
Elisabeth G E de Vries
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Bernard A Zonnenberg
Bernard A Zonnenberg
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Cornelis J Lips
Cornelis J Lips
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Anouk N A van der Horst-Schrivers
Anouk N A van der Horst-Schrivers
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Annemiek M E Walenkamp
Annemiek M E Walenkamp
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Thera P Links
Thera P Links
Departments of Medical Oncology, Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Weiss GH Alexander RB Hayes WS Long JP Thakore KN Linehan WM 1992 The natural history of renal lesions in von Hippel–Lindau disease: a serial CT study in 28 patients . AJR. American Journal of Roentgenology 159 1229 – 1234 . ( doi:10.2214/ajr.159
Julien Hadoux
Julien Hadoux
Oncologie Endocrinienne, Département d’Imagerie, Gustave Roussy, Villejuif, France
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Thomas Walter
Thomas Walter
Service d’Oncologie, ENETS Centre of Excellence, Hospices Civils de Lyon et Université de Lyon, Lyon, France
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Christina Kanaan
Christina Kanaan
Service de Pathologie, Département de Biologie et Pathologie Médicale, Gustave Roussy, Villejuif, France
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Ségolène Hescot
Ségolène Hescot
Département d’Oncologie, Institut Curie, Paris, France
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Vincent Hautefeuille
Vincent Hautefeuille
Service d’Hépato-gastro-entérologie et Cancérologie Digestive, CHU Amiens Picardie, Amiens, France
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Marine Perrier
Marine Perrier
Département d’Hépato-gastro-entérologie, CHU de Reims, Reims, France
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Igor Tauveron
Igor Tauveron
Service d'Endocrinologie, Diabétologie et Maladies Métaboliques, CHU Clermont-Ferrand, Clermont-Ferrand, France
Laboratoire GReD, Université Clermont Auvergne, Clermont-Ferrand, France
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Laboratoire GReD, Université Clermont Auvergne, Clermont-Ferrand, France
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Sandrine Laboureau
Sandrine Laboureau
Département d’Endocrinologie-Diabétologie-Nutrition, CHU d’Angers, Angers Cedex 9, France
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Christine Do Cao
Christine Do Cao
CHU de Lille, Service d’Endocrinologie, Lille, France
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Caroline Petorin
Caroline Petorin
CHU Clermont-Ferrand, Service de Chirurgie Digestive et Hépatobiliaire, Clermont-Ferrand, France
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Odile Blanchet
Odile Blanchet
CRB, CHU d’Angers, Angers Cedex 9, France
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Matthieu Faron
Matthieu Faron
Département de Chirurgie, Gustave Roussy, Villejuif, France
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Emmanuelle Leteurtre
Emmanuelle Leteurtre
CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Université de Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277, Lille, France
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Marie-Christine Rousselet
Marie-Christine Rousselet
Département de Pathologie, CHU d’Angers, Angers Cedex 9, France
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Juliette Joubert Zakeyh
Juliette Joubert Zakeyh
Laboratoire d’Anatomie Pathologique, CHU Clermont-Ferrand, Clermont-Ferrand, France
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Aude Marchal
Aude Marchal
Service d’Anatomo-Pathologie, CHU Reims, Reims, France
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Denis Chatelain
Denis Chatelain
Service d’Anatomo-Pathologie, CHU Amiens, Amiens, France
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Clément Beaulaton
Clément Beaulaton
Service d’Anatomo-Pathologie, Institut Curie, Paris, France
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Valérie Hervieu
Valérie Hervieu
Service d’Anatomo-Pathologie, ENETS Centre of Excellence, Hospices Civils de Lyon et Université de Lyon, Lyon, France
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Catherine Lombard-Bohas
Catherine Lombard-Bohas
Service d’Oncologie, ENETS Centre of Excellence, Hospices Civils de Lyon et Université de Lyon, Lyon, France
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Michel Ducreux
Michel Ducreux
Service d’Oncologie Digestive, Département de Médecine, Gustave Roussy, Villejuif, France
Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
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Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
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Jean-Yves Scoazec
Jean-Yves Scoazec
Service de Pathologie, Département de Biologie et Pathologie Médicale, Gustave Roussy, Villejuif, France
Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
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Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
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Eric Baudin
Eric Baudin
Oncologie Endocrinienne, Département d’Imagerie, Gustave Roussy, Villejuif, France
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the Groupe d’Etude des Tumeurs Endocrines (GTE)
the Groupe d’Etude des Tumeurs Endocrines (GTE)
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the ENDOCAN-RENATEN network
the ENDOCAN-RENATEN network
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they have shown efficacy in NEC, especially SCLC, EBR, topotecan, CAV (cyclophosphamide, adriamycin and vincristine) and alkylating-based chemotherapy, for example. Recently, concurrent reports have suggested that RB transcriptional corepressor 1 (RB1
Carol A Lange
Carol A Lange
Departments of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street South East, MMC 806, Minneapolis Minnesota 55455, USA
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Douglas Yee
Douglas Yee
Departments of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street South East, MMC 806, Minneapolis Minnesota 55455, USA
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Endocrine-Related Cancer suggests an effective means of targeting loss of cell cycle control in endocrine-resistant breast cancers. These investigators noted that a unique gene signature indicative of retinoblastoma (RB) protein loss of function could
Andreas Venizelos
Andreas Venizelos
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Hege Elvebakken
Hege Elvebakken
Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Aurel Perren
Aurel Perren
Institute of Pathology, University of Bern, Bern, Switzerland
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Oleksii Nikolaienko
Oleksii Nikolaienko
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Wei Deng
Wei Deng
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Inger Marie B Lothe
Inger Marie B Lothe
Department of Pathology, Oslo University Hospital, Oslo, Norway
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Anne Couvelard
Anne Couvelard
Department of Pathology, Université de Paris, Bichat Hospital, AP-HP, Paris, France
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Geir Olav Hjortland
Geir Olav Hjortland
Department of Oncology, Oslo University Hospital, Oslo, Norway
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Anna Sundlöv
Anna Sundlöv
Departmentt of Oncology, Skåne University Hospital, Lund, Sweden
Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Johanna Svensson
Johanna Svensson
Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Harrish Garresori
Harrish Garresori
Department of Oncology, Stavanger University Hospital, Stavanger, Norway
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Christian Kersten
Christian Kersten
Department of Research, Hospital of Southern Norway, Kristiansand, Norway
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Eva Hofsli
Eva Hofsli
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Department of Oncology, St.Olavs Hospital, Trondheim, Norway
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Department of Oncology, St.Olavs Hospital, Trondheim, Norway
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Sönke Detlefsen
Sönke Detlefsen
Department of Pathology, Odense University Hospital, Odense, Denmark
Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Merete Krogh
Merete Krogh
Department of Oncology, Odense University Hospital, Odense, Denmark
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Halfdan Sorbye
Halfdan Sorbye
Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Stian Knappskog
Stian Knappskog
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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( Brennan et al. 2010 , Dasari et al. 2018 ). Regarding potential biomarkers, the benefit of platinum-based treatment for pancreatic NEN G3 has been reported to depend on KRAS mutations and loss of RB1 ( Hijioka et al. 2017 ) and studies on NEC
T P Links
T P Links
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K M van Tol
K M van Tol
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P L Jager
P L Jager
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J Th M Plukker
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D A Piers
D A Piers
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H M Boezen
H M Boezen
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R P F Dullaart
R P F Dullaart
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E G E de Vries
E G E de Vries
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W J Sluiter
W J Sluiter
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In differentiated thyroid carcinoma 10-year survival rates amount to 80–95%. Because age at diagnosis varies widely, these survival rates strongly depend on age at presentation. The aim of the present study was to analyse the attributable risk factors, including therapy per se, on survival in thyroid cancer after proper adjustment for the baseline mortality rate in the general population and to elucidate the adverse treatment effects on survival. Initial treatment in 504 patients consisted of thyroidectomy and 131I ablation. High-dose 131I was administered for residual disease. Patients in complete remission underwent an annual physical examination and thyroglobulin measurements during TSH suppression. Survival time was studied after transformation to standardised survival time to adjust for the baseline mortality rate in the general population.
Median follow-up since diagnosis was 9 years. The 10-year overall survival was 83% and disease-specific survival 91%. After initial treatment, persistent disease occurred in 75 patients (15%). In univariate analysis, T4, N1, M1 status and Hürthle cell type were prognostic for persistent and recurrent disease. Age was not prognostic for recurrent disease in multivariate analysis. The standardised survival time was not altered in disease-free patients. However, patients with persistent disease had a median standardised survival time of only 0.60 (95% confidence interval 0.47;0.72), ranging from 0 to above 1, independent of initial tumour status or age. The cumulative proportion of persistent disease was at least 20% of the whole group.
Disease-free patients after thyroid carcinoma have a normal residual life span. In contrast, in cases of persistent disease the life expectancy ranges widely with its median being reduced to 60%. Overall, treatment including radioiodine is safe but unsuccesful in 20% of the patients. Age is not a disease-specific risk factor and should not be used as an independent factor in treatment algorithms.
Mairéad G McNamara
Mairéad G McNamara
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK
Division of Cancer Sciences, University of Manchester, Manchester, UK
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Division of Cancer Sciences, University of Manchester, Manchester, UK
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Jean-Yves Scoazec
Jean-Yves Scoazec
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Université Paris Sud, Faculté de Médecine de Bicêtre, Le Kremlin-Bicêtre, France
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Université Paris Sud, Faculté de Médecine de Bicêtre, Le Kremlin-Bicêtre, France
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Thomas Walter
Thomas Walter
Department of Gastroenterology and Medical Oncology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France
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-dependent helicase ATRX (ATRX) protein expression defined well differentiated NETs and abnormal p53, Rb and SMAD4 expression signified poorly differentiated NEC ( Tang et al . 2016 ). The disease-specific survival reported was 75 months and 11 months for the well
Thomas Yang Sun
Thomas Yang Sun
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Lan Zhao
Lan Zhao
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Paul Van Hummelen
Paul Van Hummelen
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Brock Martin
Brock Martin
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
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Kathleen Hornbacker
Kathleen Hornbacker
Clinical Trials Office, Stanford University, Stanford, California, USA
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HoJoon Lee
HoJoon Lee
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Li C Xia
Li C Xia
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Division of Biostatistics, Department of Epidemiology and Public Health, Albert Einstein College of Medicine, Bronx, New York, USA
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Division of Biostatistics, Department of Epidemiology and Public Health, Albert Einstein College of Medicine, Bronx, New York, USA
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Sukhmani K Padda
Sukhmani K Padda
Cedars-Sinai Medical Center, Department of Medical Oncology, Los Angeles, California, USA
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Hanlee P Ji
Hanlee P Ji
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Stanford Genome Technology Center, Stanford, California, USA
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Stanford Genome Technology Center, Stanford, California, USA
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Pamela Kunz
Pamela Kunz
Yale School of Medicine, Smilow Cancer Hospital, Yale Cancer Center, New Haven, Connecticut, USA
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organs with paired clinical outcome data. Our analysis revealed that G3 NENs had gene expression profiles that did not easily segregate by organ, that they shared mutations in TP53 , RB1 , APC , CDKN2A , and in the CDK4/6 cell cycling pathway, and
