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-associated fibroblasts (TAFs) act by inducing the expression of factors, such as the stromal-derived factor 1 (SDF1, also called CXCL12), as well as myofibroblast markers, including alpha-smooth muscle actin (α-SMA), vimentin and fibroblast surface protein. SDF1
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Lundberg Laboratory for Cancer Research, Department of Zoology, Department of Neuroscience and Physiology, Lundberg Laboratory for Cancer Research, Department of Pathology and Cytology, Sahlgrenska Academy, University of Göteborg, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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membrane integrity, angiogenesis and haematopoiesis ( Semenza 2003 ). The chemokine CXCL12 (stromal cell-derived factor 1 (SDF-1)) and its receptor C-X-C chemokine receptor type 4 (CXCR4) are known to regulate the homing process of haematopoietic cells as
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INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
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INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
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comprises 16 members, among which CXCL1 (GRO-α), CXCL2 (GRO-β), CXCL3 (GRO-γ), CXCL4 (PF4), CXCL4V1 (PF4V1), CXCL5 (ENA-78), CXCL6 (GCP-2), CXCL7 (NAP-2), CXCL8 (IL-8), CXCL9 (MIG), CXCL10 (IP-10), CXCL11 (I-TAC), and CXCL12 (SDF-1) are the most studied
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CXCL4V1 CXCL5 ENA-78 CXCR2 CXCL6 GCP-2 CXCR1, CXCR2 CXCL7 NAP-2 CXCR2 CXCL8 IL-8 CXCR1, CXCR2 CXCL9 MIG CXCR3, CXCR3B CXCL10 IP-10 CXCR3, CXCR3B CXCL11 I-TAC CXCR3, CXCR3B, CXCR7 CXCL12 SDF-1α/β CXCR4, CXCR7 CXCL13 BLC, BCA-1 CXCR5 CXCL14 BRAK
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B Arenzana-Seisdedos F Thelen M Bachelerie F 2005 The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes . Journal of Biological Chemistry 280 35760 – 35766 . Bleul CC Farzan M Choe H
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PHD Course in Experimental Medicine, University of Pavia, Pavia, Italy
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Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
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Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
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-thyroid extension in rats (Fang et al . 2014) CXCR3 CXCL4, CXCL9-10-11 Normal human thyroid cells, human TPC-1 cell line, non-metastatic human PTC (Urra et al . 2018) No data available No data available CXCR4 CXCL12 Normal human thyroid
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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characterisation of CAF and NBF cultures, we measured secretion of the chemokine CXCL12, also known as stromal derived factor-1 (SDF1), and cellular expression of α-smooth muscle actin (α-SMA). These factors may be regarded as two of the hallmarks of CAFs ( Mishra
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Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
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phenotype and IL-4, -6, -13 or stromal cell-derived factor 1 (SDF-1) for the anti-inflammatory M2 phenotype ( Comito et al. 2014 , Di Mitri et al. 2019 ), but it is also possible for macrophages to be polarised through their effector functions, for
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proliferation and invasion through autocrine/paracrine activity of SDF-1α/CXCL12 . Carcinogenesis 26 1706 – 1715 . ( https://doi.org/10.1093/carcin/bgi137 ) Lanz RB McKenna NJ Onate SA Albrecht U Wong J Tsai SY Tsai MJ O’Malley BW 1999
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Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany
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Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany
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-SMA) ACCCACAATGTCCCCATCTA GAAGGAATAGCCACGCTCAG ACTB (β-actin) AGAAAATCTGGCACCACACC TAGCACAGCCTGGATAGCAA CXCL12 (SDF-1) AGAGCCAACGTCAAGCATCT CTTTAGCTTCGGGTCAATGC DES (desmin) AAGCTGCAGGAGGAGATTCA GGCAGTGAGGTCTGGCTTAG EGF CAGGGAAGATGACCACCACT CAGTTCCCACCACTTCAGGT FAP