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Takako Araki, Ning-Ai Liu, Yukiko Tone, Daniel Cuevas-Ramos, Roy Heltsley, Masahide Tone, and Shlomo Melmed

results are representative of three independent experiments (D). hPOMC transcription is regulated by E2F1 Ser-337 phosphorylation As E2F1 DNA binding was modulated by R-roscovitine, we assessed whether E2F1 phosphorylation status affects E2F

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Catherine M Olsen, Christina M Nagle, David C Whiteman, Roberta Ness, Celeste Leigh Pearce, Malcolm C Pike, Mary Anne Rossing, Kathryn L Terry, Anna H Wu, The Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Study Group, Harvey A Risch, Herbert Yu, Jennifer A Doherty, Jenny Chang-Claude, Rebecca Hein, Stefan Nickels, Shan Wang-Gohrke, Marc T Goodman, Michael E Carney, Rayna K Matsuno, Galina Lurie, Kirsten Moysich, Susanne K Kjaer, Allan Jensen, Estrid Hogdall, Ellen L Goode, Brooke L Fridley, Robert A Vierkant, Melissa C Larson, Joellen Schildkraut, Cathrine Hoyo, Patricia Moorman, Rachel P Weber, Daniel W Cramer, Allison F Vitonis, Elisa V Bandera, Sara H Olson, Lorna Rodriguez-Rodriguez, Melony King, Louise A Brinton, Hannah Yang, Montserrat Garcia-Closas, Jolanta Lissowska, Hoda Anton-Culver, Argyrios Ziogas, Simon A Gayther, Susan J Ramus, Usha Menon, Aleksandra Gentry-Maharaj, and Penelope M Webb

(GER) 1993–1998 21–75 Germany 254 519 Hospital admissions (58%) Ser 106 (42%) Ser 15 (6%) Population registries (51%) Y Y Muc 26 (10%) Muc 9 (4%) End 26 (10%) Other 3 (1%) CC 6 (2%) Other 63 (25%)  Hawaii Ovarian Cancer Study (HAW) 1993–2008 18

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J A Vendrell, I Bieche, C Desmetz, E Badia, S Tozlu, C Nguyen, J C Nicolas, R Lidereau, and P A Cohen

enter to S phase in the three cell lines (Fig. 1 , compare panel A with B, E with F and I with J). However, the proportion of cells in the S phase under E 2 treatment was greater in the two OTR cell lines than in the MVLN cells (35 vs 26%; Fig. 1

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Tobias Krauss, Alfonso Massimiliano Ferrara, Thera P Links, Ulrich Wellner, Irina Bancos, Andrey Kvachenyuk, Karina Villar Gómez de las Heras, Marina Y Yukina, Roman Petrov, Garrett Bullivant, Laura von Duecker, Swati Jadhav, Ursula Ploeckinger, Staffan Welin, Camilla Schalin-Jäntti, Oliver Gimm, Marija Pfeifer, Joanne Ngeow, Kornelia Hasse-Lazar, Gabriela Sansó, Xiaoping Qi, M Umit Ugurlu, Rene E Diaz, Nelson Wohllk, Mariola Peczkowska, Jens Aberle, Delmar M Lourenço Jr, Maria A A Pereira, Maria C B V Fragoso, Ana O Hoff, Madson Q Almeida, Alice H D Violante, Ana R P Quidute, Zhewei Zhang, Mònica Recasens, Luis Robles Díaz, Tada Kunavisarut, Taweesak Wannachalee, Sirinart Sirinvaravong, Eric Jonasch, Simona Grozinsky-Glasberg, Merav Fraenkel, Dmitry Beltsevich, Viacheslav I Egorov, Dirk Bausch, Matthias Schott, Nikolaus Tiling, Gianmaria Pennelli, Stefan Zschiedrich, Roland Därr, Juri Ruf, Timm Denecke, Karl-Heinrich Link, Stefania Zovato, Ernst von Dobschuetz, Svetlana Yaremchuk, Holger Amthauer, Özer Makay, Attila Patocs, Martin K Walz, Tobias B Huber, Jochen Seufert, Per Hellman, Raymond H Kim, Ekaterina Kuchinskaya, Francesca Schiavi, Angelica Malinoc, Nicole Reisch, Barbara Jarzab, Marta Barontini, Andrzej Januszewicz, Nalini Shah, William F Young Jr, Giuseppe Opocher, Charis Eng, Hartmut P H Neumann, and Birke Bausch

>T p.Ala56Val 1 1 1/0 1 c.188T>G p.Leu63Arg 1 1 1/0 1 c.191G>C p.Arg64Pro 1 2 2/0 1 c.194C>G p.Ser65Trp 2 1 1/0 1 c.194C>T p.Ser65Leu 1 1 1/0 1 c.202T>C p.Ser68Pro 1

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Cindy M Staka, Robert I Nicholson, and Julia M W Gee

al. 2001 , Chen et al. 2002 ). Interestingly, we (and others including Shou et al. 2004 ) have shown that increased nuclear ER phosphorylation on Ser118ER and Ser167ER occurs as a consequence of elevated EGFR/HER2/IGF-1R-regulated MAPK and AKT

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Fabio L Forti and Hugo A Armelin

, 5 min, 4 °C), loaded on 10% SDS-PAGE gels (150 μg protein aliquots), and finally processed for western blotting. Total Erk1/2 or Thr202/Tyr204-phosphorylated ERK1/2, total Akt or Ser473-phosphorylated Akt, and total GSK-3α/β or Ser21/9-phosphorylated

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M Muşat, M Korbonits, B Kola, N Borboli, M R Hanson, A M Nanzer, J Grigson, S Jordan, D G Morris, M Gueorguiev, M Coculescu, S Basuand, and A B Grossman

quantification of Akt1, Akt2 and PTEN transcripts using a TaqMan Gold assay (PE-Applied Biosystems). Total RNA (1 μg) for each sample was reverse transcribed in a 50 μl reaction. Another five dilutions of mRNA from a different sample (i.e. 1, 0.2, 0.04, 0.008 and

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Misu Lee, Ninelia Minaskan, Tobias Wiedemann, Martin Irmler, Johannes Beckers, Behrooz H Yousefi, Georgios Kaissis, Rickmer Braren, Iina Laitinen, and Natalia S Pellegata

chromaffin cell function such as catecholamine secretion or exocytosis (i.e. Serpine1 , +11.18; VGF , +10.42; SV2c , +3.37; Npy , +1.88) were significantly induced by BEZ235 treatment. Altogether, PI3K/mTOR inhibition induced gene expression changes

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Monia Zidane, Jean-Baptiste Cazier, Sylvie Chevillard, Catherine Ory, Martin Schlumberger, Corinne Dupuy, Jean-François Deleuze, Anne Boland, Nadia Haddy, Fabienne Lesueur, and Florent de Vathaire

regulatory binding sites of EWSR1-FLI1, E2F1 and AP-2α ( Tcheandjieu et al. 2016 ). These latter proteins are indeed overexpressed in sporadic PTC cases and may play a role in PTC pathogenesis ( Di Vito et al. 2011 ). NKX2-1 NKX2-1 at 14q13

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Matthias Beyens, Timon Vandamme, Marc Peeters, Guy Van Camp, and Ken Op de Beeck

& Sabatini 2017 ). Once mTORC1 is activated, it can regulate the activity of eukaryotic translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal S6 kinase 1 and 2 (S6K1/2) ( Fig. 3A ). Under basal conditions, 4E-BP1 remains bound to