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Fidéline Bonnet-Serrano and Jérôme Bertherat

pigmented micro-nodules widespread in adrenal cortex. PPNAD is usually diagnosed in patients with Cushing syndrome while PBMAH can cause variable degree of cortisol excess. The molecular mechanisms of tumorigenesis are not the same in these different types

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Kiran Nadella, Fabio R Faucz, and Constantine A Stratakis

that produce cortisol in a corticotropin-independent manner, unlike the surrounding adrenal cortex which is frequently atrophic; these nodules may be detected by the cellular accumulation of pigment (i.e. lipofuscin) and using specific immunostaining

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Patricia de Cremoux, Dan Rosenberg, Jacques Goussard, Catherine Brémont-Weil, Frédérique Tissier, Carine Tran-Perennou, Lionnel Groussin, Xavier Bertagna, Jérôme Bertherat, and Marie-Laure Raffin-Sanson

) and monkeys ( Hirst et al . 1992 ), whereas PR was not detected in these species. During fetal development, large amounts of ERβ mRNA are present in the definitive zone of the human adrenal cortex. In these tissues, ERβ mRNA levels have been shown to

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Alessio Imperiale, Karim Elbayed, François-Marie Moussallieh, Nathalie Reix, Martial Piotto, Jean-Pierre Bellocq, Bernard Goichot, Philippe Bachellier, and Izzie-Jacques Namer

Introduction The adrenal gland is a fascinating organ with two functionally distinct structures called the adrenal cortex and medulla, each with its own embryonic origin. While the adrenal cortex derives from mesoderm, the adrenal medulla is

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Sisi Liu, Emmanouil Saloustros, Annabel Berthon, Matthew F Starost, Isabelle Sahut-Barnola, Paraskevi Salpea, Eva Szarek, Fabio R Faucz, Antoine Martinez, and Constantine A Stratakis

PRKAR1A , a gene coding for the type 1a regulatory subunit (R1α) of cAMP-dependent protein kinase (PKA) ( Kirschner et al . 2000 , Stratakis 2008 ). Prkar1a mice with the gene entirely knocked out (KO) specifically in the adrenal cortex (AdKO

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Masanori Murakami, Takanobu Yoshimoto, Kazuhiko Nakabayashi, Yujiro Nakano, Takahiro Fukaishi, Kyoichiro Tsuchiya, Isao Minami, Ryotaro Bouchi, Kohji Okamura, Yasuhisa Fujii, Koshi Hashimoto, Ken-ichiro Hata, Kazunori Kihara, and Yoshihiro Ogawa

42 adrenal tumors were compared to microarray data from normal adrenal cortex (Gene Expression Omnibus [GEO] accession no. GSE68889), which included transcriptomes for adrenocortical layers, the zona glomerulosa (ZG) and zona fasciculate (ZF), from

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Yunhui Cheng, Raili Emilia Kerppola, and Tom Klaus Kerppola

damage to the adrenal cortex (adrenalytic activity). Some inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT; sterol O-acyl transferase; SOAT), which were originally developed for the treatment of atherosclerosis, have adrenalytic activity

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A R Glover, J T Zhao, J C Ip, J C Lee, B G Robinson, A J Gill, P S H Soon, and S B Sidhu

being greatly advanced by the advent of high-throughput genomic medicine, which has shown that ACCs have distinct genome-wide expression, microRNA expression and methylation profiles compared with adrenal cortical adenomas (ACAs) and normal adrenal

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T M A Kerkhofs, M H T Ettaieb, I G C Hermsen, and H R Haak

Introduction Cancer of the adrenal cortex (ACC) occurs in about 1–2 people per million, which renders it a rare endocrine malignancy ( Kebebew et al . 2006 , Fassnacht & Allolio 2009 ). Complete surgical resection is the sole curative option. In

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Barbara Mariniello, Antonio Rosato, Gaia Zuccolotto, Beatrice Rubin, Maria Verena Cicala, Isabella Finco, Maurizio Iacobone, Anna Chiara Frigo, Ambrogio Fassina, Raffaele Pezzani, and Franco Mantero

survival in xenograft mouse models in vivo . The adult adrenal cortex is a highly vascularized organ that abundantly expresses VEGF, possibly to maintain a high density of stable fenestrated microvessels ( Shweiki et al . 1993 ). Our experiments confirm