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Milena Doroszko
Milena Doroszko
Institute of Biomedicine, University of Turku, Turku, Finland
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Marcin Chrusciel
Marcin Chrusciel
Institute of Biomedicine, University of Turku, Turku, Finland
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Joanna Stelmaszewska
Joanna Stelmaszewska
Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland
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Tomasz Slezak
Tomasz Slezak
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA
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Slawomir Anisimowicz
Slawomir Anisimowicz
Center of Gynecology and Reproductive Endocrinology Artemida, Bialystok, Poland
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Ursula Plöckinger
Ursula Plöckinger
Interdisciplinary Center of Metabolism: Endocrinology, Diabetes and Metabolism, Charité University Medicine Berlin, Berlin, Germany
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Marcus Quinkler
Marcus Quinkler
Endocrinology in Charlottenburg, Berlin, Germany
Department of Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany
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Department of Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany
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Marco Bonomi
Marco Bonomi
Department of Clinical Sciences & Community Health, University of Milan, Milan, Italy
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Slawomir Wolczynski
Slawomir Wolczynski
Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland
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Ilpo Huhtaniemi
Ilpo Huhtaniemi
Institute of Biomedicine, University of Turku, Turku, Finland
Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, U.K.
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Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, U.K.
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Jorma Toppari
Jorma Toppari
Institute of Biomedicine, University of Turku, Turku, Finland
Department of Pediatrics, Turku University Hospital, Turku, Finland
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Department of Pediatrics, Turku University Hospital, Turku, Finland
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Nafis A Rahman
Nafis A Rahman
Institute of Biomedicine, University of Turku, Turku, Finland
Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland
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Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland
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, Chrusciel et al. 2014 ). Intact inhα/Tag mice develop gonadal tumors, but when prepubertally gonadectomized, adrenocortical tumors appear with a hyperplasia-adenoma-adenocarcinoma sequence and abundant LHCGR expression ( Kananen et al. 1995 , 1996
Ana Carolina Bueno
Ana Carolina Bueno
Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Rui M P da Silva
Rui M P da Silva
Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Mônica F Stecchini
Mônica F Stecchini
Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Junier Marrero-Gutiérrez
Junier Marrero-Gutiérrez
Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Danillo C de Almeida e Silva
Danillo C de Almeida e Silva
Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
Department of Computation and Mathematics, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Department of Computation and Mathematics, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Izilda Cardinalli
Izilda Cardinalli
Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil
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Carlos Alberto Scrideli
Carlos Alberto Scrideli
Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Thais Junqueira
Thais Junqueira
Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil
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Carlos A F Molina
Carlos A F Molina
Department of Surgery and Anatomy Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Fernando Silva Ramalho
Fernando Silva Ramalho
Department of Pathology Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Silvio Tucci Jr
Silvio Tucci Jr
Department of Surgery and Anatomy Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Fernanda Borchers Coeli-Lacchini
Fernanda Borchers Coeli-Lacchini
Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Ayrton Custodio Moreira
Ayrton Custodio Moreira
Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Leandra N Z Ramalho
Leandra N Z Ramalho
Department of Pathology Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Silvia Brandalise
Silvia Brandalise
Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil
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José Andres Yunes
José Andres Yunes
Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil
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Margaret de Castro
Margaret de Castro
Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Ricardo Zorzetto Nicoliello Vêncio
Ricardo Zorzetto Nicoliello Vêncio
Department of Computation and Mathematics, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Sonir R R Antonini
Sonir R R Antonini
Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Introduction Pediatric adrenocortical tumors (pACT) are rare and represent about 0.2% of all childhood cancers ( Gulack et al. 2016 ). pACT present distinct clinical and prognostic features from the disease in adults, usually presenting with
Patricia de Cremoux
Patricia de Cremoux
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Dan Rosenberg
Dan Rosenberg
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Jacques Goussard
Jacques Goussard
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Catherine Brémont-Weil
Catherine Brémont-Weil
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Frédérique Tissier
Frédérique Tissier
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Carine Tran-Perennou
Carine Tran-Perennou
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Lionnel Groussin
Lionnel Groussin
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Xavier Bertagna
Xavier Bertagna
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Jérôme Bertherat
Jérôme Bertherat
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Marie-Laure Raffin-Sanson
Marie-Laure Raffin-Sanson
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
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Introduction Unilateral tumors account for most cases of adrenocorticotrophin (ACTH)-independent hypercortisolism and may be classified into benign adrenal adenomas (ACAs) and malignant adrenocortical carcinomas (ACCs). ACCs have an extremely poor
Zsófia Tömböl
Zsófia Tömböl
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Peter M Szabó
Peter M Szabó
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Viktor Molnár
Viktor Molnár
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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Zoltán Wiener
Zoltán Wiener
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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Gergely Tölgyesi
Gergely Tölgyesi
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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János Horányi
János Horányi
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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Peter Riesz
Peter Riesz
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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Peter Reismann
Peter Reismann
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Attila Patócs
Attila Patócs
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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István Likó
István Likó
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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Rolf-Christian Gaillard
Rolf-Christian Gaillard
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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András Falus
András Falus
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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Károly Rácz
Károly Rácz
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Peter Igaz
Peter Igaz
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Introduction Sporadic adrenocortical tumors are common, and their prevalence reaches up to 7–9% in pathological series ( Koch et al . 2002 ). Most of these are incidentally discovered, hormonally inactive benign tumors, whereas rare hormone
Barbara Mariniello
Barbara Mariniello
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Antonio Rosato
Antonio Rosato
Endocrinology Unit, Department of Surgery, Istituto Oncologico Veneto IRCCS, Endocrine Surgery Unit, Department of Environmental Medicine and Public Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
Endocrinology Unit, Department of Surgery, Istituto Oncologico Veneto IRCCS, Endocrine Surgery Unit, Department of Environmental Medicine and Public Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
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Endocrinology Unit, Department of Surgery, Istituto Oncologico Veneto IRCCS, Endocrine Surgery Unit, Department of Environmental Medicine and Public Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
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Gaia Zuccolotto
Gaia Zuccolotto
Endocrinology Unit, Department of Surgery, Istituto Oncologico Veneto IRCCS, Endocrine Surgery Unit, Department of Environmental Medicine and Public Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
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Beatrice Rubin
Beatrice Rubin
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Maria Verena Cicala
Maria Verena Cicala
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Isabella Finco
Isabella Finco
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Maurizio Iacobone
Maurizio Iacobone
Endocrinology Unit, Department of Surgery, Istituto Oncologico Veneto IRCCS, Endocrine Surgery Unit, Department of Environmental Medicine and Public Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
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Anna Chiara Frigo
Anna Chiara Frigo
Endocrinology Unit, Department of Surgery, Istituto Oncologico Veneto IRCCS, Endocrine Surgery Unit, Department of Environmental Medicine and Public Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
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Ambrogio Fassina
Ambrogio Fassina
Endocrinology Unit, Department of Surgery, Istituto Oncologico Veneto IRCCS, Endocrine Surgery Unit, Department of Environmental Medicine and Public Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
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Raffaele Pezzani
Raffaele Pezzani
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Franco Mantero
Franco Mantero
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Introduction Adrenocortical masses are common tumors, with a prevalence of at least 3% in the population over the age of 50 years; they are incidentally discovered up to 5% on abdominal imaging and 15% of patients at autopsy ( Grumbach et al . 2003
Régia Caroline Peixoto Lira
Régia Caroline Peixoto Lira
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Paola Fernanda Fedatto
Paola Fernanda Fedatto
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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David Santos Marco Antonio
David Santos Marco Antonio
Department of Research and Development, Fleury Group, Sao Paulo, São Paulo, Brazil
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Letícia Ferro Leal
Letícia Ferro Leal
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Carlos Eduardo Martinelli
Carlos Eduardo Martinelli
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Margaret de Castro
Margaret de Castro
Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Silvio Tucci
Silvio Tucci
Department of Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Luciano Neder
Luciano Neder
Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Leandra Ramalho
Leandra Ramalho
Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Ana Luiza Seidinger
Ana Luiza Seidinger
Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
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Izilda Cardinalli
Izilda Cardinalli
Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
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Maria José Mastellaro
Maria José Mastellaro
Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
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José Andres Yunes
José Andres Yunes
Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil
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State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil
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Silvia Regina Brandalise
Silvia Regina Brandalise
Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil
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State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil
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Luiz Gonzaga Tone
Luiz Gonzaga Tone
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Sonir Roberto Rauber Antonini
Sonir Roberto Rauber Antonini
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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Carlos Alberto Scrideli
Carlos Alberto Scrideli
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil
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clinical and pathological features of adrenocortical tumors in a large series of pediatric patients’ samples and investigated the effect of IGF1R inhibition by OSI-906 in the ACC cell line NCI-H295A as well as the altered downstream signaling pathways
Susanna Vuorenoja
Susanna Vuorenoja
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Adolfo Rivero-Müller
Adolfo Rivero-Müller
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Adam J Ziecik
Adam J Ziecik
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Ilpo Huhtaniemi
Ilpo Huhtaniemi
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Jorma Toppari
Jorma Toppari
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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Nafis A Rahman
Nafis A Rahman
Department of Physiology, Department of Pediatrics, Institute of Animal Reproduction and Food Research, Department of Reproductive Biology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
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-castration elevation of LH levels apparently induced the ectopic LHR expression, which together with the potent oncogene Tag expression triggered adrenocortical tumorigenesis ( Mikola et al . 2003 ). LH dependence of the tumors was proven by findings that they failed
Maria Cristina De Martino
Maria Cristina De Martino
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Richard A Feelders
Richard A Feelders
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Wouter W de Herder
Wouter W de Herder
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Peter M van Koetsveld
Peter M van Koetsveld
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Fadime Dogan
Fadime Dogan
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Joseph A M J L Janssen
Joseph A M J L Janssen
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A Marlijn Waaijers
A Marlijn Waaijers
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Claudia Pivonello
Claudia Pivonello
Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Steven W J Lamberts
Steven W J Lamberts
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Annamaria Colao
Annamaria Colao
Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Ronald R de Krijger
Ronald R de Krijger
Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Rosario Pivonello
Rosario Pivonello
Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy
Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands
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Leo J Hofland
Leo J Hofland
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negative, 2–3 as low, 4–5 as intermediate, and 6 as high. Finally, adrenocortical tumors (ATs) were dichotomously grouped as having intermediate to high expression of the evaluated protein and phosphoproteins (IHC score ≥4) or not (IHC score <4). In AHs and
P S H Soon
P S H Soon
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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A J Gill
A J Gill
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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D E Benn
D E Benn
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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A Clarkson
A Clarkson
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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B G Robinson
B G Robinson
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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K L McDonald
K L McDonald
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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S B Sidhu
S B Sidhu
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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) can be difficult. The Weiss score, a nine-point histopathological scoring system, is presently the most widely used system for classifying adrenocortical tumors (ACTs) as benign or malignant. A total score of ≤2 is typically associated with a benign
Susanna Vuorenoja
Susanna Vuorenoja
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Bidut Prava Mohanty
Bidut Prava Mohanty
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Johanna Arola
Johanna Arola
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Ilpo Huhtaniemi
Ilpo Huhtaniemi
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Jorma Toppari
Jorma Toppari
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Nafis A Rahman
Nafis A Rahman
Departments of, Physiology, Pediatrics, Department of Pathology, Institute of Reproductive and Developmental Biology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
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Introduction Adrenocortical tumors are rare and aggressive as they often are diagnosed late and have poor survival rate ( Schulick & Brennan 1999 a ). These tumors are 1.5-fold more common in females than males with peak incidences in the first and
