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Xiaqing Xu
Xiaqing Xu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Meimei Si
Meimei Si
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Honggang Lou
Honggang Lou
Department of Clinical Pharmacology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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Youyou Yan
Youyou Yan
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Yunxi Liu
Yunxi Liu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Hong Zhu
Hong Zhu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Xiaoe Lou
Xiaoe Lou
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Jian Ma
Jian Ma
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Difeng Zhu
Difeng Zhu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Honghai Wu
Honghai Wu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Bo Yang
Bo Yang
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Haoshu Wu
Haoshu Wu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Ling Ding
Ling Ding
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Qiaojun He
Qiaojun He
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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. Adriamycin (ADR) is widely used as a first-line anti-hepatoma drug alone or in combination ( Judson et al . 2014 ). Multiple action mechanisms are involved in ADR-induced apoptosis, intercalating with DNA and RNA synthesis, inhibiting topoisomerase II
J-H Chen
J-H Chen
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R Ling
R Ling
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Q Yao
Q Yao
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Y Li
Y Li
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T Chen
T Chen
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Z Wang
Z Wang
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K-Z Li
K-Z Li
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Introduction Adriamycin (ADR) plays an important role in the treatment of breast cancer. In addition to being a mainstay of therapy in the adjuvant and neoadjuvant settings, ADR is widely used in chemotherapy regimens for patients
Ana Albero
Ana Albero
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Juliana Ester Lopéz
Juliana Ester Lopéz
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Alberto Torres
Alberto Torres
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Luis de la Cruz
Luis de la Cruz
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Tomas Martín
Tomas Martín
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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cytostatics have been tested in small studies with different results, but of all of them adriamycin in monotherapy has been traditionally considered the standard therapy ( Gottlieb et al . 1972 , Leeper & Shimaoka 1980 , Poster et al . 1981 , Schlumberger
Xiaqing Xu
Xiaqing Xu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Meimei Si
Meimei Si
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Honggang Lou
Honggang Lou
Department of Clinical Pharmacology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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Youyou Yan
Youyou Yan
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Yunxi Liu
Yunxi Liu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Hong Zhu
Hong Zhu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Xiaoe Lou
Xiaoe Lou
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Jian Ma
Jian Ma
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Difeng Zhu
Difeng Zhu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Honghai Wu
Honghai Wu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Bo Yanz
Bo Yanz
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Haoshu Wu
Haoshu Wu
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Ling Ding
Ling Ding
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Qiaojun He
Qiaojun He
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
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Elisa Roca
Elisa Roca
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Oncology Unit, ASST Spedali Civili di Brescia, Brescia, Italy
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Alfredo Berruti
Alfredo Berruti
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Oncology Unit, ASST Spedali Civili di Brescia, Brescia, Italy
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Silviu Sbiera
Silviu Sbiera
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg, Germany
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Ida Rapa
Ida Rapa
Department of Oncology, University of Turin, Pathology Unit, San Luigi Gonzaga Hospital, Orbassano, Italy
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Ester Oneda
Ester Oneda
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Oncology Unit, ASST Spedali Civili di Brescia, Brescia, Italy
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Paola Sperone
Paola Sperone
Department of Oncology, University of Turin, Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy
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Cristina L Ronchi
Cristina L Ronchi
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg, Germany
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Laura Ferrari
Laura Ferrari
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Oncology Unit, ASST Spedali Civili di Brescia, Brescia, Italy
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Salvatore Grisanti
Salvatore Grisanti
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Oncology Unit, ASST Spedali Civili di Brescia, Brescia, Italy
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Antonina Germano
Antonina Germano
Department of Clinical and Biological Sciences, University of Turin, Internal Medicine 1, San Luigi Gonzaga Hospital, Orbassano, Italy
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Barbara Zaggia
Barbara Zaggia
Department of Clinical and Biological Sciences, University of Turin, Internal Medicine 1, San Luigi Gonzaga Hospital, Orbassano, Italy
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Giorgio Vittorio Scagliotti
Giorgio Vittorio Scagliotti
Department of Oncology, University of Turin, Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy
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Martin Fassnacht
Martin Fassnacht
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg, Germany
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Marco Volante
Marco Volante
Department of Oncology, University of Turin, Pathology Unit, San Luigi Gonzaga Hospital, Orbassano, Italy
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Massimo Terzolo
Massimo Terzolo
Department of Clinical and Biological Sciences, University of Turin, Internal Medicine 1, San Luigi Gonzaga Hospital, Orbassano, Italy
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Mauro Papotti
Mauro Papotti
Department of Oncology, University of Turin, Pathology Unit, City of Health and Science Hospital, Turin, Italy
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cytotoxic drug in ACC and it is actually unknown whether EDP is more efficacious than cisplatin alone since no randomized studies have been conducted. In our opinion, these data suggest the importance of Adriamycin and etoposide in the EDP scheme
Bertrand Brieau
Bertrand Brieau
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Olivia Hentic
Olivia Hentic
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Rachida Lebtahi
Rachida Lebtahi
Service de médecine nucléaire, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Maxime Palazzo
Maxime Palazzo
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Makrem Ben Reguiga
Makrem Ben Reguiga
Département de pharmacie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Vinciane Rebours
Vinciane Rebours
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Frederique Maire
Frederique Maire
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Pascal Hammel
Pascal Hammel
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Philippe Ruszniewski
Philippe Ruszniewski
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Pierre Fenaux
Pierre Fenaux
Service d’hématologie, Hôpital Saint Louis, AP-HP, Université Paris Diderot, Paris, France
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resection None 25, 121 months Left ischial tuberosity and occipital part of the skull G2 4, 29.9, PR None Yes CT at 54 months: streptozotocin+adriamycin+interferon (9), PR G2 NE, G1 TH TACE at 75 months
P J Barrett-Lee
P J Barrett-Lee
Cardiff Breast Unit, Velindre NHS Trust, Cardiff CF14 2 TL, UK
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relation to anthracycline-containing regimens such as 5-fluorouracil adriamycin cyclophosphamide (FAC)/FEC or AC/epirubicin cyclophosphamide (EC) are not numerous. In a recent study from Belgium, 59 patients were selected form a database of 350 patients
Alfredo Berruti
Alfredo Berruti
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Massimo Terzolo
Massimo Terzolo
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Paola Sperone
Paola Sperone
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Anna Pia
Anna Pia
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Silvia Della Casa
Silvia Della Casa
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David J Gross
David J Gross
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Carlo Carnaghi
Carlo Carnaghi
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Paolo Casali
Paolo Casali
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Francesco Porpiglia
Francesco Porpiglia
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Franco Mantero
Franco Mantero
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Giuseppe Reimondo
Giuseppe Reimondo
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Alberto Angeli
Alberto Angeli
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Luigi Dogliotti
Luigi Dogliotti
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respect to the original EDP scheme, the dose of etoposide was reduced from 120 mg/m 2 to 100 mg/m 2 while the doses of cisplatin and adriamycin did not change. The feasibility of the EDP scheme in association with mitotane was tested by our group in
Justin S Gundara
Justin S Gundara
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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JingTing Zhao
JingTing Zhao
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Bruce G Robinson
Bruce G Robinson
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Stan B Sidhu
Stan B Sidhu
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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cell lines (DU145 and PC3); effect on autophagy and cell response to adriamycin observed EGFR knockdown induces autophagy in vitro ; loss of EGFR knockdown-related autophagy enhances the therapeutic response to adriamycin Xu & Weihua (2011) Prostate
Robert C Smallridge
Robert C Smallridge
Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine
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Laura A Marlow
Laura A Marlow
Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine
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John A Copland
John A Copland
Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine
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resectability, radiotherapy, and distant metastases at diagnosis. At the Roswell Cancer Institute, 21 patients were treated between 1968 and 1992 ( Tan et al . 1995 ). Five had complete resection, 18 received XRT, and six were given adriamycin +/− one or more
