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David Viola
David Viola
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Laura Valerio
Laura Valerio
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Laura Agate
Laura Agate
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Valeria Bottici
Valeria Bottici
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Agnese Biagini
Agnese Biagini
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Loredana Lorusso
Loredana Lorusso
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Virginia Cappagli
Virginia Cappagli
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Letizia Pieruzzi
Letizia Pieruzzi
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Carlotta Giani
Carlotta Giani
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Elena Sabini
Elena Sabini
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Paolo Passannati
Paolo Passannati
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Luciana Puleo
Luciana Puleo
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Antonio Matrone
Antonio Matrone
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Benedetta Pontillo-Contillo
Benedetta Pontillo-Contillo
Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Valentina Battaglia
Valentina Battaglia
Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Salvatore Mazzeo
Salvatore Mazzeo
Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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. 2013 ). Until recently, no effective therapeutic options have been available for patients with any type of advanced thyroid cancer. In fact, EBRT has significant toxicity and mainly plays a palliative role, and classical cytotoxic chemotherapies have
Eyun Song
Eyun Song
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Dong Eun Song
Dong Eun Song
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Jonghwa Ahn
Jonghwa Ahn
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Tae Yong Kim
Tae Yong Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Won Bae Kim
Won Bae Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Young Kee Shong
Young Kee Shong
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Min Ji Jeon
Min Ji Jeon
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Won Gu Kim
Won Gu Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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thyroid carcinomas (PTCs) to develop a homogeneous cohort ( Cancer Genome Atlas Research Network 2014 ). Limited data exist regarding the mutational profile in advanced thyroid cancers, such as poorly differentiated thyroid carcinomas (PDTCs), anaplastic
Mabel Ryder
Mabel Ryder
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Ronald A Ghossein
Ronald A Ghossein
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Julio C M Ricarte-Filho
Julio C M Ricarte-Filho
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Jeffrey A Knauf
Jeffrey A Knauf
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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James A Fagin
James A Fagin
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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density of TAMs ( n =3) and tumors with a high density of TAMs ( n =3). Discussion Our study demonstrates, for the first time, that an increased density of TAMs is associated with tumor progression in advanced thyroid cancers. There is a remarkably strong
Xiangqian Zheng
Xiangqian Zheng
Thyroid Neck Oncology Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin, China
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Meiyu Fang
Meiyu Fang
Department of Thoracic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
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Yun Fan
Yun Fan
Department of Thoracic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
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Yuping Sun
Yuping Sun
Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China
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Meili Sun
Meili Sun
Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China
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Ankui Yang
Ankui Yang
Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Bin Zhang
Bin Zhang
Head and Neck Surgery Department, Beijing Cancer Hospital, Beijing, Beijing, China
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Qinjiang Liu
Qinjiang Liu
Head and Neck Surgery, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China
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Hui Liu
Hui Liu
Head and Neck Oncology Surgical Department, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China
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Xiaohong Zhou
Xiaohong Zhou
Head and Neck Surgery, Chongqing Cancer Hospital, Chongqing, Chongqing, China
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Tao Huang
Tao Huang
Breast and Thyroid Surgery, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China
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Jianwu Qin
Jianwu Qin
Head and Neck Surgery, Henan Cancer Hospital, Zhengzhou, Henan, China
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Zhaohui Wang
Zhaohui Wang
Head and Neck Surgery Department, Sichuan Cancer Hospital & Institute, Chengdu, Sichuan, China
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Mengmeng Qin
Mengmeng Qin
Clinical Department, CStone Pharmaceuticals (Suzhou) Co., Ltd., Suzhou, Jiangsu, China
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Zhenwei Shen
Zhenwei Shen
Clinical Department, CStone Pharmaceuticals (Suzhou) Co., Ltd., Suzhou, Jiangsu, China
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Sheng Yao
Sheng Yao
Clinical Department, CStone Pharmaceuticals (Suzhou) Co., Ltd., Suzhou, Jiangsu, China
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Jason Yang
Jason Yang
Clinical Department, CStone Pharmaceuticals (Suzhou) Co., Ltd., Suzhou, Jiangsu, China
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Yu Wang
Yu Wang
Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China
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Ming Gao
Ming Gao
Thyroid Neck Oncology Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin, China
Department of Breast and Thyroid Surgery, Tianjin Union Medical Center, Tianjin, Tianjin, China
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Department of Breast and Thyroid Surgery, Tianjin Union Medical Center, Tianjin, Tianjin, China
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–2 treatment-related adverse events reported in at least 10% of patients and all grades 3–5 events are shown. MTC, medullary thyroid cancer; RET , rearranged during transfection. Discussion To date, Chinese patients with advanced MTC
Marcia S Brose
Marcia S Brose
Department of Medical Oncology, Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Jaume Capdevila
Jaume Capdevila
Gastrointestinal and Endocrine Tumor Unit, Medical Oncology Department, Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
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Rossella Elisei
Rossella Elisei
Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Lars Bastholt
Lars Bastholt
Department of Clinical Oncology, Odense University Hospital, Odense, Denmark
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Dagmar Führer-Sakel
Dagmar Führer-Sakel
Department of Endocrinology, Diabetes and Metabolism and Clinical Chemistry, University Hospital Essen, Essen, Germany
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France
Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Hôpitaux Universitaires de Genève, Geneve, Switzerland
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Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Hôpitaux Universitaires de Genève, Geneve, Switzerland
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Iwao Sugitani
Iwao Sugitani
Department of Endocrine Surgery, Nippon Medical School Graduate School of Medicine, Tokyo, Japan
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Matthew H Taylor
Matthew H Taylor
Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA
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Zhuoying Wang
Zhuoying Wang
Department of Head Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Head Neck Surgery, Renji Hospital Affiliated to Jiaotong University School of Medicine, Shanghai, China
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Department of Head Neck Surgery, Renji Hospital Affiliated to Jiaotong University School of Medicine, Shanghai, China
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Lori J Wirth
Lori J Wirth
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Francis P Worden
Francis P Worden
Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
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John Bernard
John Bernard
Sanofi, Cambridge, Massachusetts, USA
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Paolo Caferra
Paolo Caferra
Sanofi, Amsterdam, The Netherlands
Department of Pharmacy, University of Pisa, Pisa, Italy
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Department of Pharmacy, University of Pisa, Pisa, Italy
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Raffaella M Colzani
Raffaella M Colzani
Sanofi, Cambridge, Massachusetts, USA
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Shiguang Liu
Shiguang Liu
Sanofi, Cambridge, Massachusetts, USA
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Martin Schlumberger
Martin Schlumberger
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France
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confirmed histological diagnosis of locally advanced or metastatic DTC (including poorly differentiated thyroid cancer and follicular DTC) not amenable to surgical resection, external beam radiotherapy, or other local therapies. Measurable disease, as
Mimi I Hu
Mimi I Hu
Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Marek Dedecjus
Marek Dedecjus
M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
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Aron Popovtzer
Aron Popovtzer
Davidoff Cancer Center, Tel-Aviv University, Petah Tikva, Israel
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Maralyn Druce
Maralyn Druce
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
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Ellen Kapiteijn
Ellen Kapiteijn
Leiden University Medical Center, Leiden, The Netherlands
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Furio Pacini
Furio Pacini
Thyroid Unit, University of Siena, Siena, Italy
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Laura Locati
Laura Locati
Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Jolanta Krajewska
Jolanta Krajewska
M. Sklodowska-Curie Memorial Institute Cancer Center, Gliwice Branch, Gliwice, Poland
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Richard Weiss
Richard Weiss
Sanofi Genzyme, Cambridge, Massachusetts, USA
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Robert F Gagel
Robert F Gagel
Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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advanced medullary thyroid cancer: review of adverse event management strategies . Advances in Therapy 30 945 – 966 . ( https://doi.org/10.1007/s12325-013-0069-5 ) 24249433 10.1007/s12325-013-0069-5 Hundahl SA Fleming ID Fremgen AM Menck HR 1998
Olga Karapanou
Olga Karapanou
Endocrine Department, 401 General Military Hospital of Athens, Athens, Greece
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George Simeakis
George Simeakis
Endocrine Department, 401 General Military Hospital of Athens, Athens, Greece
Department of Clinical Therapeutics, Alexandra Hospital Athens University School of Medicine, Endocrine Unit, Athens, Greece
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Department of Clinical Therapeutics, Alexandra Hospital Athens University School of Medicine, Endocrine Unit, Athens, Greece
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Barbara Vlassopoulou
Barbara Vlassopoulou
Endocrine Department, Evangelismos Athens General Hospital, Athens, Greece
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Maria Alevizaki
Maria Alevizaki
Department of Clinical Therapeutics, Alexandra Hospital Athens University School of Medicine, Endocrine Unit, Athens, Greece
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Katerina Saltiki
Katerina Saltiki
Department of Clinical Therapeutics, Alexandra Hospital Athens University School of Medicine, Endocrine Unit, Athens, Greece
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reasons or after nuclear accidents. The acquisition of further activating mutations in other genes or loss of function mutations in tumor suppressor genes ex TP53 is a frequent event in advanced thyroid cancer leading to dedifferentiation ( Fagin & Wells
Tara Williamson
Tara Williamson
Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA
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Thais Biude Mendes
Thais Biude Mendes
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Universidade Federal de São Paulo, São Paulo, Brazil
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Natalie Joe
Natalie Joe
Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA
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Janete M Cerutti
Janete M Cerutti
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Universidade Federal de São Paulo, São Paulo, Brazil
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Gregory J Riggins
Gregory J Riggins
Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA
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-stage papillary thyroid cancers (>5 cm in diameter), resulting in increased annual mortality rates in thyroid cancer in the United States ( Lim et al . 2017 ). PTC can progress to advanced poorly differentiated (PDTC) or anaplastic (ATC) subtypes without the
Ana Albero
Ana Albero
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Juliana Ester Lopéz
Juliana Ester Lopéz
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Alberto Torres
Alberto Torres
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Luis de la Cruz
Luis de la Cruz
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Tomas Martín
Tomas Martín
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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SS Karamouzis MV Burmeister LA 2008 A phase II trial of doxorubicin and interferon alpha 2b in advanced, non-medullary thyroid cancer . Investigational New Drugs 26 183 – 188 . ( doi:10.1007/s10637-007-9091-2 ). Benker G Reinwein D
Xianhui Ruan
Xianhui Ruan
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xianle Shi
Xianle Shi
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Qiman Dong
Qiman Dong
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Yang Yu
Yang Yu
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xiukun Hou
Xiukun Hou
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xinhao Song
Xinhao Song
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Xi Wei
Xi Wei
Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Lingyi Chen
Lingyi Chen
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Ming Gao
Ming Gao
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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, radioiodine, and thyroid hormone therapy ( McFarland & Misiukiewicz 2014 ). However, there are few treatment options available for patients with advanced disease, including radioiodine-resistant and metastatic differentiated thyroid cancer and anaplastic
