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Yu-Ling Lu Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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Yu-Tung Huang Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Ming-Hsien Wu Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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Ting-Chao Chou Laboratory of Preclinical Pharmacology Core, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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Richard J Wong Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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Shu-Fu Lin Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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Introduction Anaplastic thyroid cancer (ATC) is a rare disease with an incidence of 1–2 per million people per year. ATC is classified as stage IV disease and is one of the most lethal cancers with a median survival of 3–5 months upon

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Robert C Smallridge Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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Laura A Marlow Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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John A Copland Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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, Rocha et al . (2003) evaluated 17 poorly differentiated (but no anaplastic) thyroid cancers. They found loss of cadherin 1, type 1, E-cadherin (epithelial) membrane expression, but no nuclear localization of catenin (cadherin-associated protein), beta

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Amit Mehta Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Lisa Zhang Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Myriem Boufraqech Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Yaqin Zhang Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Dhaval Patel Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Min Shen Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Electron Kebebew Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

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Introduction Thyroid cancer is the most common endocrine malignancy ( Howlader et al . 2013 ). Anaplastic thyroid cancer (ATC) accounts for 1–2% of all thyroid cancers, but is the most common cause of thyroid-cancer-related deaths ( Kebebew et al

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Jiajun Wu Graduate Department, Bengbu Medical College, Bengbu, Anhui, China
Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Juyong Liang Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Ruiqi Liu Graduate Department, Bengbu Medical College, Bengbu, Anhui, China

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Tian Lv Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Kangyin Fu Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Liehao Jiang Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Wenli Ma Graduate Department, Bengbu Medical College, Bengbu, Anhui, China
Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Yan Pan Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Zhuo Tan Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Qing Liu Department of Thyroid and Breast Surgery, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie, Guizhou, China

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Weihua Qiu Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Minghua Ge Graduate Department, Bengbu Medical College, Bengbu, Anhui, China
Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China

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Jiafeng Wang Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Department of Thyroid and Breast Surgery, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie, Guizhou, China

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. (D) and (E) Images and quantifications of TUNEL assay and IHC staining of Ki67, P62, LC3B, HO-1, and GPX4. (F) Schematic of anlotinib-mediated autophagy-ferroptosis signaling in anaplastic thyroid cancer. Tumorigenic markers were assayed by

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Xuguang Zhu Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland, USA

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Li Zhao Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland, USA

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Woo Kyung Lee Doolittle Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland, USA

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Sheue-yann Cheng Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland, USA

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Introduction Anaplastic thyroid cancer (ATC) is one of the most aggressive solid cancers in humans. ATC is usually resistant to conventional radioactive iodine therapy or chemotherapy. At the time of diagnosis, most ATC patients are ineligible

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Francesca Marano Department of Medical Sciences, University of Turin, Turin, Italy

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Roberto Frairia Department of Medical Sciences, University of Turin, Turin, Italy

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Letizia Rinella Department of Medical Sciences, University of Turin, Turin, Italy

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Monica Argenziano Department of Drug Science and Technology, University of Turin, Turin, Italy

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Benedetta Bussolati Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy

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Cristina Grange Department of Medical Sciences, University of Turin, Turin, Italy

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Raffaella Mastrocola Department of Clinical and Biological Sciences, University of Turin, Turin, Italy

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Isabella Castellano Department of Medical Sciences, University of Turin, Turin, Italy

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Laura Berta Med & Sport 2000 Srl, Turin, Italy

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Roberta Cavalli Department of Drug Science and Technology, University of Turin, Turin, Italy

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Maria Graziella Catalano Department of Medical Sciences, University of Turin, Turin, Italy

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Introduction Anaplastic thyroid cancer (ATC) is one of the most lethal cancers, its median survival being only 5 months, and 1-year survival being less than 20% ( Smallridge & Copland 2010 ). To date, a standard therapy for ATC does not exist

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Gahee Park Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Tae Hyuk Kim Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Hae-Ock Lee Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Jung Ah Lim Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Jae-Kyung Won Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Hye Sook Min Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Kyu Eun Lee Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Do Joon Park Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Young Joo Park Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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Woong-Yang Park Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of

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K Hayashi Y Nakachi K Kusunoki Y 2012 Rearranged anaplastic lymphoma kinase ( ALK ) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors . Thyroid 22 1153 – 1159 . ( doi:10.1089/thy.2011.0511 ). Kelly LM Barila

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Woo Kyung Lee Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Won Gu Kim Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

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Laura Fozzatti Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Sunmi Park Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Li Zhao Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Mark C Willingham Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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David Lonard Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Bert W O’Malley Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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Sheue-yann Cheng Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Introduction Anaplastic thyroid carcinoma (ATC) is a rare malignancy, accounting for 1–2% of all thyroid cancers, but it is one of the most aggressive solid cancers in humans ( Molinaro et al . 2017 ). ATC is highly proliferative, easily

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Kristen Wong Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Francesca Di Cristofano Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Michela Ranieri Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Daniela De Martino Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Antonio Di Cristofano Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Introduction Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer subtype, with a median overall survival of less than 9 months when patients are treated with multimodal therapy and less than 3 months with palliative care

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M Onda
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M Emi
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A Yoshida
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S Miyamoto
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J Akaishi
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T Tanaka
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T Tsunoda
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Introduction Thyroid cancers are classified as medullary, papillary, follicular or anaplastic. The medullary type derives from parafollicular C cells; papillary, follicular and anaplastic cancer originate from follicular cells of the

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