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Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan
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Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan
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Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan
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Introduction Anaplastic thyroid cancer (ATC) is a rare disease with an incidence of 1–2 per million people per year. ATC is classified as stage IV disease and is one of the most lethal cancers with a median survival of 3–5 months upon
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, Rocha et al . (2003) evaluated 17 poorly differentiated (but no anaplastic) thyroid cancers. They found loss of cadherin 1, type 1, E-cadherin (epithelial) membrane expression, but no nuclear localization of catenin (cadherin-associated protein), beta
Endocrine Oncology Branch, Geisel School of Medicine at Dartmouth, National Institutes of Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
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Introduction Thyroid cancer is the most common endocrine malignancy ( Howlader et al . 2013 ). Anaplastic thyroid cancer (ATC) accounts for 1–2% of all thyroid cancers, but is the most common cause of thyroid-cancer-related deaths ( Kebebew et al
Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
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Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Department of Thyroid and Breast Surgery, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie, Guizhou, China
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. (D) and (E) Images and quantifications of TUNEL assay and IHC staining of Ki67, P62, LC3B, HO-1, and GPX4. (F) Schematic of anlotinib-mediated autophagy-ferroptosis signaling in anaplastic thyroid cancer. Tumorigenic markers were assayed by
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Introduction Anaplastic thyroid cancer (ATC) is one of the most aggressive solid cancers in humans. ATC is usually resistant to conventional radioactive iodine therapy or chemotherapy. At the time of diagnosis, most ATC patients are ineligible
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Introduction Anaplastic thyroid cancer (ATC) is one of the most lethal cancers, its median survival being only 5 months, and 1-year survival being less than 20% ( Smallridge & Copland 2010 ). To date, a standard therapy for ATC does not exist
Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
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Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
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Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
Samsung Genome Institute, Internal Medicine, Surgery, Biomedical Sciences, Department of Internal Medicine, Department of Molecular Cell Biology, Samsung Medical Center, 50 Irwondong, Gangnamgu, Seoul 135-710, Korea Departments of
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K Hayashi Y Nakachi K Kusunoki Y 2012 Rearranged anaplastic lymphoma kinase ( ALK ) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors . Thyroid 22 1153 – 1159 . ( doi:10.1089/thy.2011.0511 ). Kelly LM Barila
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Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
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Introduction Anaplastic thyroid carcinoma (ATC) is a rare malignancy, accounting for 1–2% of all thyroid cancers, but it is one of the most aggressive solid cancers in humans ( Molinaro et al . 2017 ). ATC is highly proliferative, easily
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Introduction Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer subtype, with a median overall survival of less than 9 months when patients are treated with multimodal therapy and less than 3 months with palliative care
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Introduction Thyroid cancers are classified as medullary, papillary, follicular or anaplastic. The medullary type derives from parafollicular C cells; papillary, follicular and anaplastic cancer originate from follicular cells of the