, Shiau et al. 2005 ). PPARγ agonists regulate development and cellular growth and metabolism in various tissues. In particular, they mediate adipocyte differentiation, which has led to an examination of their potential anti-tumour effects. PPARγ
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Manali Mody, Nachiket Dharker, Mark Bloomston, Pei-Shan Wang, Fu-Sheng Chou, Theodore S Glickman, Timothy McCaffrey, Zhaoqing Yang, Anne Pumfery, Daniel Lee, Matthew D Ringel, and Joseph J Pinzone
Martyn E Caplin, Marianne Pavel, Jarosław B Ćwikła, Alexandria T Phan, Markus Raderer, Eva Sedláčková, Guillaume Cadiot, Edward M Wolin, Jaume Capdevila, Lucy Wall, Guido Rindi, Alison Langley, Séverine Martinez, Edda Gomez-Panzani, Philippe Ruszniewski, and on behalf of the CLARINET Investigators
Introduction CLARINET was a landmark 96-week study that confirmed anti-tumour effects for the long-acting somatostatin analogue lanreotide Autogel (depot in the USA) 120 mg. Lanreotide prolonged progression-free survival (PFS) over placebo in
Michael Höpfner, Viola Baradari, Alexander Huether, Christof Schöfl, and Hans Scherübl
inhibition, induction of apoptosis and cell-cycle arrest in NE gastrointestinal tumour cells. Moreover, we checked for additive anti-neoplastic effects of NVP-AEW541 when combined with conventional cytostatic drugs or the 3-hydroxy-3-methylglutaryl coenzyme A
Michele Caraglia, Daniele Santini, Monica Marra, Bruno Vincenzi, Giuseppe Tonini, and Alfredo Budillon
anti-proliferative effects of NBPs. Two mechanisms of NBP-induced tumour growth inhibition have been described: cell cycle disruption and apoptosis. In this regard, it has recently been demonstrated in vitro that NBPs, such as PAM and ZOL, induce
Simona Grozinsky-Glasberg, Ilan Shimon, Márta Korbonits, and Ashley B Grossman
SSA anti-proliferative, apoptotic and anti-angiogenetic effects are summarised (using reports on tissues other than NETs as well, as data specific to NETs are few) and second, in which the clinical symptomatic, biochemical and tumour-shrinkage effects
C Schaaf, B Shan, M Buchfelder, M Losa, J Kreutzer, W Rachinger, G K Stalla, T Schilling, E Arzt, M J Perone, and U Renner
might have therapeutic effects on pituitary tumours. Cell cycle arrest induced by curcumin treatment on pituitary tumour cell lines Having demonstrated the anti-proliferative effect of curcumin in pituitary tumour cells, FACS analysis was performed to
Kathrin A Schmohl, Andrea M Müller, Alexandra Wechselberger, Svenja Rühland, Nicole Salb, Nathalie Schwenk, Heike Heuer, Janette Carlsen, Burkhard Göke, Peter J Nelson, and Christine Spitzweg
. 2015 ). In contrast, tetrac exerts a tumour growth-inhibitory effect based on the inhibition of T 3 /T 4 effects, but also on agonist-independent direct anti-angiogenic and pro-apoptotic effects ( Davis et al . 2011 , Yalcin et al . 2013 ). In this
Pedro Marques, Sayka Barry, Eivind Carlsen, David Collier, Amy Ronaldson, Sherine Awad, Neil Dorward, Joan Grieve, Nigel Mendoza, Samiul Muquit, Ashley B Grossman, Frances Balkwill, and Márta Korbonits
). In addition to their inhibitory effects on tumour cells ( Ibanez-Costa & Korbonits 2017 ), they may also display an indirect anti-tumoural effect by targeting cells of the tumour microenvironment, as shown in a recent study where the anti
Matthias Schott
Introduction Therapeutic cancer vaccines are intended to activate the immune system for treating an existing tumour or preventing its recurrence. Anti-tumour immunity is coordinated by both innate and adaptive immunity, and mainly
Kathrin A Schmohl, Peter J Nelson, and Christine Spitzweg
its anti-tumour activity. Aside from angiogenesis, chemokine signalling is also fundamental for intra- and intercellular communication in the tumour microenvironment. Effects on transcription of other angiogenesis-relevant genes Tetrac and
