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Anika Nagelkerke Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology
Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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Anieta M Sieuwerts Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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Johan Bussink Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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Fred C G J Sweep Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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Maxime P Look Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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John A Foekens Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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John W M Martens Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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Paul N Span Departments of Radiation Oncology, Laboratory Medicine, Department of Medical Oncology

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and are related to the development of insensitivity of the ER or alterations in signaling through the ER ( Osborne 1998 , Giuliano et al . 2011 ). Treatment of breast cancer cells with tamoxifen was found to induce the process of autophagy (Greek for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0183
Volume/Issue:
Volume 21: Issue 1
Free access
Biao Wan Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Leheyi Dai Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Li Wang Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Ying Zhang Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Hong Huang Hospital of Stomatology, Chongqing Medical University, Chongqing, China

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Guanhua Qian Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Tinghe Yu Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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-intact cells. Knockdown of BRCA2 can enhance the cytotoxicty of CDDP and can improve autophagy. CQ enhanced CDDP against BRCA2 -silenced cells, suggesting that modulation of autophagy can be a chemosensitizer for ovarian cancer with a low BRCA2 level

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0261
Volume/Issue:
Volume 25: Issue 1
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Tiago Vieira Augusto UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

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Georgina Correia-da-Silva UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

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Cecília M P Rodrigues Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal

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Natércia Teixeira UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

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Cristina Amaral UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

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region of ER-regulated genes and the recruitment of co-activators to initiate classical genomic transcriptional modulation. The ER can also interact with other transcription factors such as activator protein 1 (AP-1) to bind DNA indirectly, leading to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0425
Volume/Issue:
Volume 25: Issue 5
Free access
Justin S Gundara Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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JingTing Zhao Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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Bruce G Robinson Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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Stan B Sidhu Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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.1158/0008-5472.CAN-08-1573 ). Ding ZB Hui B Shi YH Zhou J Peng YF Gu CY Yang H Shi GM Ke AW Wang XY 2011 Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0325
Volume/Issue:
Volume 19: Issue 6
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Andrea Weckman Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Fabio Rotondo Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Antonio Di Ieva Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Luis V Syro Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Henriett Butz Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Michael D Cusimano Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Kalman Kovacs Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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), suggesting that therapeutic modulation of autophagy may be a promising field of research. In fact, there have been several studies and clinical trials exploring the use of the mTOR inhibitor RAD001 (or everolimus), as well as the receptor tyrosine kinase

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0042
Volume/Issue:
Volume 22: Issue 4
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Federica Morani Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Rossella Titone Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Loredana Pagano Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Alessandra Galetto Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Oscar Alabiso Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Gianluca Aimaretti Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Ciro Isidoro Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Modulation of autophagy could be combined with TRAIL for the treatment of thyroid cancer Jin et al . (2013) 3-MA, 3-methyladenine. Detection of autophagy in thyroid cancer cells The expression of autophagy protein markers can be demonstrated in ex

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0271
Volume/Issue:
Volume 21: Issue 1
Free access
Weijun Wei Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Heather Hardin Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

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Quan-Yong Luo Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Oncology 14 247 – 258 . ( https://doi.org/10.1038/nrclinonc.2016.183 ) 27845767 Galluzzi L Bravo-San Pedro JM Levine B Green DR Kroemer G 2017 b Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles . Nature

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0502
Volume/Issue:
Volume 26: Issue 4
Free access
Shani Avniel-Polak Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Gil Leibowitz Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Victoria Doviner Department of Pathology, Shaare Zedek Medical Center, Jerusalem, Israel

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David J Gross Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Autophagy modulation as a potential therapeutic target for diverse diseases . Nature Reviews Drug Discovery 11 709 – 730 . ( https://doi.org/10.1038/nrd3802 ) 22935804 10.1038/nrd3802 Seitz C Hugle M Cristofanon S Tchoghandjian A Fulda S 2013 The

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0121
Volume/Issue:
Volume 25: Issue 6
Free access
Nan Liu Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China
Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China

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Sheng Tai Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China
Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China

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Boxiao Ding Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China

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Ryan K Thor Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China

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Sunita Bhuta Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China

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Yin Sun Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China

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Jiaoti Huang Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China
Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Biology, Department of Urology and Anhui Geriatric Institute, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, People's Republic of China

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anticancer effect of ATO with Rad001 and the underlying mechanisms in human ovarian cancer cells in vitro and in vivo . We found that the enhanced cytotoxic effect of Rad001 combined with ATO was through enhanced induction of autophagy and apoptosis. In

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0150
Volume/Issue:
Volume 19: Issue 5
Free access
Angelique Huijbers Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Theo S Plantinga Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE
Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Leo A B Joosten Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE
Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Katja K H Aben Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE
Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Julius Gudmundsson Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Martin den Heijer Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Lambertus A L M Kiemeney Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE
Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE
Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Mihai G Netea Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE
Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Ad R M M Hermus Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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Romana T Netea-Maier Department of Endocrinology, Department of Internal Medicine, Nijmegen Institute of Infection, Department of Epidemiology, Department of Urology, Department of Cancer Registry and Research, deCODE

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pathophysiology of the TC malignant process. One of the main mammalian autophagy proteins is autophagy related 16-like 1 (ATG16L1), which is essential for autophagosome formation, induction of autophagy, and modulation of inflammation ( Saitoh et al . 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0302
Volume/Issue:
Volume 19: Issue 3
Free access