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Eva Hadadi Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium
Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium

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Hervé Acloque INSERM U935, University Paris Saclay, Villejuif, Ile-de-France, France
Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, Ile-de-France, France

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be hallmarks of cancer (31) are directly regulated by the circadian clock. Specific biological processes under circadian regulation are specified in red. Circadian rhythm disruption and endocrine related cancers The adaptation of animal

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Arun Mouli Kolinjivadi Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore

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Siao Ting Chong Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore

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Joanne Ngeow Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore

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rhythm that follow a 24-h periodicity governing the essential cellular and molecular events. Several landmark studies in mammals, zebrafish, plants, fungi and cyanobacteria support the concept of biological clock or circadian rhythm impacting different

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Ewan M Stephenson Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore

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Laura E J Usselmann Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Vinay Tergaonkar Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore

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David M Virshup Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore

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Robert Dallmann Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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centuries since, oscillations that coordinate normal physiology with the 24 h light:24 h darkness cycle have been discovered across the kingdoms of life ( Rosbash 2009 ). Disrupted circadian rhythms contribute to many human diseases including diabetes

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Zsofia Kiss VA Northern California Health Care System, Mather, California, USA
Department of Urology, University of California at Davis, Sacramento, California, USA

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Paramita M Ghosh VA Northern California Health Care System, Mather, California, USA
Department of Urology, University of California at Davis, Sacramento, California, USA
Department of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, California, USA

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responsible for maintaining circadian rhythms may result in deregulation of clock-associated biological processes, such as androgen expression, and consequently influence an individual’s risk of prostate cancer’ ( Zhu et al . 2006 ). In support of a role for

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Anna Angelousi Endocrine Unit, 1st Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Eva Kassi Endocrine Unit, 1st Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Narjes Ansari-Nasiri Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Harpal Randeva Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Gregory Kaltsas Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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George Chrousos First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Introduction Circadian rhythms are biological rhythms that exhibit a periodicity close to 24 h. In mammals, these rhythms are generated by a master biological clock, located centrally in the suprachiasmatic nucleus (SCN) of the hypothalamus

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Rebecca B Riggins Lombardi Comprehensive Cancer Center and Department of Oncology, Department of Physiology and Biophysics, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA

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Mary M Mazzotta Lombardi Comprehensive Cancer Center and Department of Oncology, Department of Physiology and Biophysics, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA

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Omar Z Maniya Lombardi Comprehensive Cancer Center and Department of Oncology, Department of Physiology and Biophysics, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA

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Robert Clarke Lombardi Comprehensive Cancer Center and Department of Oncology, Department of Physiology and Biophysics, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
Lombardi Comprehensive Cancer Center and Department of Oncology, Department of Physiology and Biophysics, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA

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regulates metabolism and circadian rhythm ( Duez & Staels 2009 ). Despite its orphan status, Rev-Erbα and the related Rev-Erbβ (NR1D2) are known to bind heme ( Burris 2008 ). Rev-Erbα is localized to chromosome 17q21, a region that is frequently amplified in

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Thérèse Truong Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Benoît Liquet Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Florence Menegaux Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Sabine Plancoulaine Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Pierre Laurent-Puig Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Claire Mulot Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Emilie Cordina-Duverger Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Marie Sanchez Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Patrick Arveux Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Pierre Kerbrat Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Sylvia Richardson Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Pascal Guénel Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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-regulated feedback loop. The circadian rhythm pathway plays a key role in the maintenance of various endocrine, physiological, and behavioral functions including cell cycle regulation, hormone secretion, body temperature, and sleep/wake cycle. The disruption of the

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Steven M Hill Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Victoria P Belancio Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Robert T Dauchy Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Shulin Xiang Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Samantha Brimer Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Lulu Mao Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Adam Hauch Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Peter W Lundberg Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Whitney Summers Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Lin Yuan Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Tripp Frasch Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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David E Blask Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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maintained by the circadian organization of these daily bioenergetic, metabolic, signaling, and proliferative activities into coordinated rhythms that help ultimately slow the expansion of tumor biomass. Both host and tumor rhythms are driven by the circadian

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Jennifer F Barger Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, Ohio 45267, USA

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David R Plas Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, Ohio 45267, USA

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energetic demand. Period proteins associate with cryptochrome (CRY) proteins to regulate the activity of the central circadian rhythm transcription factors BMAL1 and Clock. Circadian rhythm is established through a negative feedback loop in which period

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Christina Wei St George’s University Hospital, NHS Foundation Trust, London, UK

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Elizabeth C Crowne Bristol Royal Hospital for Children, University Hospitals Bristol, NHS Foundation Trust, Bristol, UK

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.6–10 year FU: 3.6–10 year Age at FU: 6.9–18.2 year RT: all had 18.9 (18–24) Gy, 10–12# ITT 24 h ACTH and cortisol profiling 20-min intervals • ITT: normal peak cortisol responses Profiles: normal preserved circadian rhythm ACTH

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