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Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
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Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, Ile-de-France, France
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be hallmarks of cancer (31) are directly regulated by the circadian clock. Specific biological processes under circadian regulation are specified in red. Circadian rhythm disruption and endocrine related cancers The adaptation of animal
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Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore
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Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore
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rhythm that follow a 24-h periodicity governing the essential cellular and molecular events. Several landmark studies in mammals, zebrafish, plants, fungi and cyanobacteria support the concept of biological clock or circadian rhythm impacting different
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore
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centuries since, oscillations that coordinate normal physiology with the 24 h light:24 h darkness cycle have been discovered across the kingdoms of life ( Rosbash 2009 ). Disrupted circadian rhythms contribute to many human diseases including diabetes
Department of Urology, University of California at Davis, Sacramento, California, USA
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Department of Urology, University of California at Davis, Sacramento, California, USA
Department of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, California, USA
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responsible for maintaining circadian rhythms may result in deregulation of clock-associated biological processes, such as androgen expression, and consequently influence an individual’s risk of prostate cancer’ ( Zhu et al . 2006 ). In support of a role for
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Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Introduction Circadian rhythms are biological rhythms that exhibit a periodicity close to 24 h. In mammals, these rhythms are generated by a master biological clock, located centrally in the suprachiasmatic nucleus (SCN) of the hypothalamus
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Lombardi Comprehensive Cancer Center and Department of Oncology, Department of Physiology and Biophysics, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
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regulates metabolism and circadian rhythm ( Duez & Staels 2009 ). Despite its orphan status, Rev-Erbα and the related Rev-Erbβ (NR1D2) are known to bind heme ( Burris 2008 ). Rev-Erbα is localized to chromosome 17q21, a region that is frequently amplified in
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France
Université Paris-Sud UMRS 1018, Villejuif, France
Biostatistical Unit MRC, Cambridge, UK
School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France
Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France
Département d'informatique médicale Center Georges-François Leclerc, Dijon, France
Center Eugène Marquis Rennes, France
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-regulated feedback loop. The circadian rhythm pathway plays a key role in the maintenance of various endocrine, physiological, and behavioral functions including cell cycle regulation, hormone secretion, body temperature, and sleep/wake cycle. The disruption of the
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
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maintained by the circadian organization of these daily bioenergetic, metabolic, signaling, and proliferative activities into coordinated rhythms that help ultimately slow the expansion of tumor biomass. Both host and tumor rhythms are driven by the circadian
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energetic demand. Period proteins associate with cryptochrome (CRY) proteins to regulate the activity of the central circadian rhythm transcription factors BMAL1 and Clock. Circadian rhythm is established through a negative feedback loop in which period
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.6–10 year FU: 3.6–10 year Age at FU: 6.9–18.2 year RT: all had 18.9 (18–24) Gy, 10–12# ITT 24 h ACTH and cortisol profiling 20-min intervals • ITT: normal peak cortisol responses Profiles: normal preserved circadian rhythm ACTH