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Takako Araki, Ning-Ai Liu, Yukiko Tone, Daniel Cuevas-Ramos, Roy Heltsley, Masahide Tone, and Shlomo Melmed

). Subcellular mechanisms for ectopic Cushing’s syndrome are poorly defined. ACTH produced by post-translational cleavage from the proopiomelanocortin (POMC) precursor is abundantly expressed in pituitary corticotroph cells and in the hypothalamus ( Stevens

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Luis G Perez-Rivas, Andrea Oßwald, Thomas Knösel, Kristin Lucia, Christian Schaaf, Michael Hristov, Julia Fazel, Thomas Kirchner, Felix Beuschlein, Martin Reincke, and Marily Theodoropoulou

-mediated human POMC expression in ectopic Cushing’s syndrome . Endocrine-Related Cancer 23 857 – 870 . ( doi:10.1530/ERC-16-0206 ) Coates PJ Doniach I Howlett TA Rees LH Besser GM 1986 Immunocytochemical study of 18 tumours

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Georgios K Dimitriadis, Anna Angelousi, Martin O Weickert, Harpal S Randeva, Gregory Kaltsas, and Ashley Grossman

similar endocrine tumour-derived PNS ( Table 2 ). Table 2 Ectopic Cushing’s syndrome (CS): differences in clinical, laboratory and radiological features compared to eutopic secretion. Syndrome Mediator Tumour Clinical

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Gregory Kaltsas, Ioannis I Androulakis, Wouter W de Herder, and Ashley B Grossman

ectopic ACTH production by (neuroendocrine) prostate carcinoma . Pituitary 12 280 – 283 . Arnaldi G Mancini T Kola B Appolloni G Freddi S Concettoni C Bearzi I Masini A Boscaro M Mantero F 2003 Cyclical Cushing's syndrome in a

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R van der Pas, W W de Herder, L J Hofland, and R A Feelders

:10.1530/eje.0.1510173 ). Aniszewski JP Young WF Jr Thompson GB Grant CS van Heerden JA 2001 Cushing syndrome due to ectopic adrenocorticotropic hormone secretion . World Journal of Surgery 25 934 – 940 . ( doi:10.1007/s00268

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Carole Guerin, David Taieb, Giorgio Treglia, Thierry Brue, André Lacroix, Frederic Sebag, and Frederic Castinetti

. ( doi:10.1016/0002-9610(82)90010-1 ). Santhanam P Taieb D Giovanella L Treglia G 2015 PET imaging in ectopic Cushing syndrome: a systematic review . Endocrine 50 297 – 305 . ( doi:10.1007/s12020-015-0689-4 ). Sharma ST Nieman LK

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Dimitra A Vassiliadi and Stylianos Tsagarakis

carcinomas (rare) • ACTH-dependent hyperplasia  ο Cushing’s disease (Fig. 2C) or ectopic ACTH secretion  ο Congenital adrenal hyperplasia  ο GR resistance syndrome Non-adrenal tumors • Metastases (Fig. 2B) • Lymphoma • Myelolipomas

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Fidéline Bonnet-Serrano and Jérôme Bertherat

-dependent Cushing’s syndrome . Journal of Clinical Endocrinology and Metabolism 91 3611 – 3618 . ( https://doi.org/10.1210/jc.2006-0221 ) 10.1210/jc.2006-0221 Lee S Hwang R Lee J Rhee Y Kim DJ Chung U-I Lim S-K 2005 Ectopic expression of vasopressin V1b

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Yu-fang Bi, Rui-xin Liu, Lei Ye, Hai Fang, Xiao-ying Li, Wei-qing Wang, Ji Zhang, Kan-Kan Wang, Lei Jiang, Ting-wei Su, Zhong-yuan Chen, and Guang Ning

adenocarcinomas. Carcinoid tumors derived from the thymus were first documented in 1972 ( Rosai & Higa 1972 ). It can be associated with ectopic ACTH syndrome or may be a component of multiple endocrine neoplasia syndrome type 1 (MEN1). Most carcinoids are benign

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Catherine Goudie, Fady Hannah-Shmouni, Mahmure Kavak, Constantine A Stratakis, and William D Foulkes

. 2013 ARMC5 mutations in macronodular adrenal hyperplasia with Cushing’s syndrome . New England Journal of Medicine 369 2105 – 2114 . ( https://doi.org/10.1056/NEJMoa1304603 ) 10.1056/NEJMoa1304603 Azevedo MF Faucz FR Bimpaki E Horvath A