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neoplasia, endocrine tumors occur more rarely ( Table 1 ). Endocrine tumors are defined as neoplasia of the hormone-secreting cells of the classic endocrine glands, including the pituitary, thyroid, parathyroid and adrenal glands, as well as the ovaries and
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Introduction Pancreatic endocrine tumors (PETs) are uncommon neoplasms with an incidence of <1 per 100 000 person-years in population studies ( Moldow & Connelly 1968 , Buchanan et al . 1986 , Eriksson et al . 1989 , Watson et al . 1989
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Lady Davis Institute, Jewish General Hospital and Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
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in pediatric tumors including Wilms tumor and in pituitary blastoma (PitB), as well as in tumors of various endocrine organs ( Hill et al . 2009 , Huang & Yao 2010 , Schultz et al . 2011 , Heravi-Moussavi et al . 2012 , Darrat et al . 2013
The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA
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Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA
Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
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Introduction Endocrine tumors are a heterogeneous collection of malignancies that originate from cells that can secrete hormones ( Latteyer et al. 2016 ). These are generally found in the tissues of the endocrine system, such as the thyroid
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endocrine tumors have been conducted (with the exception of thyroid tumors), although there are several indications pointing towards a possible role of BRAF in this type of tumor also. First, like melanomas ( Dupin & Le Douarin 2003 ), a subset of endocrine
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third epibranchial placode (nodose placode) ( Baker 2005 ). Vagal paragangliomas Tumor origin and molecular genetics Vagus nerve paraganglia belong to the family of parasympathetic paraganglia. Members act as chemoreceptors and are involved
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-time PCR (A and B); Oct-1 and hPTTG1 protein levels were measured by western blot (C and D). Oct-1 and hPTTG1 are concordantly expressed in endocrine tumors and colon cancers hPTTG1 is overexpressed in multiple human tumors including pituitary, breast, and
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of tumor classification schemes. Together with the identification of novel genetic alterations, these results have profound implications for the treatment of cancer patients. Tumors of endocrine organs are similarly genomic diseases. Compared to
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Introduction Pancreatic endocrine tumors (PETs) are uncommon, mostly well-differentiated and indolent neuroendocrine neoplasms, with an age-adjusted annual incidence of <1 per 100 000 ( Buchanan et al. 1986 ). The molecular
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Introduction The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict on the basis of their histological features. The presence of metastases is generally accepted to be the only definitive feature of