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Andrea Weckman Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Fabio Rotondo Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Antonio Di Ieva Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Luis V Syro Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Henriett Butz Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Michael D Cusimano Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Kalman Kovacs Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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neoplasia, endocrine tumors occur more rarely ( Table 1 ). Endocrine tumors are defined as neoplasia of the hormone-secreting cells of the classic endocrine glands, including the pituitary, thyroid, parathyroid and adrenal glands, as well as the ovaries and

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Thorvardur R Halfdanarson
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Joseph Rubin
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Michael B Farnell Division of Oncology, Department of Surgery, Department of Health Sciences Research, Department of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

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Clive S Grant Division of Oncology, Department of Surgery, Department of Health Sciences Research, Department of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

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Gloria M Petersen Division of Oncology, Department of Surgery, Department of Health Sciences Research, Department of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

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Introduction Pancreatic endocrine tumors (PETs) are uncommon neoplasms with an incidence of <1 per 100 000 person-years in population studies ( Moldow & Connelly 1968 , Buchanan et al . 1986 , Eriksson et al . 1989 , Watson et al . 1989

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Michael Solarski Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital, Toronto, Ontario, Canada

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Fabio Rotondo Division of Pathology, Department of Laboratory Medicine, St. Michael’s Hospital, Toronto, Ontario, Canada

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William D Foulkes Department of Human Genetics, Medicine and Oncology, McGill University, Montreal, Quebec, Canada
Lady Davis Institute, Jewish General Hospital and Research Institute, McGill University Health Centre, Montreal, Quebec, Canada

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John R Priest Department of Medicine, Minneapolis, Minnesota, USA

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Luis V Syro Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia

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Henriett Butz Molecular Medicine Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary

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Michael D Cusimano Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital, Toronto, Ontario, Canada

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Kalman Kovacs Division of Pathology, Department of Laboratory Medicine, St. Michael’s Hospital, Toronto, Ontario, Canada

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in pediatric tumors including Wilms tumor and in pituitary blastoma (PitB), as well as in tumors of various endocrine organs ( Hill et al . 2009 , Huang & Yao 2010 , Schultz et al . 2011 , Heravi-Moussavi et al . 2012 , Darrat et al . 2013

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Aleksander Skardal Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA
The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA

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Hemamylammal Sivakumar Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA

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Marco A Rodriguez Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA

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Liudmila V Popova Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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Priya H Dedhia The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA
Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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Introduction Endocrine tumors are a heterogeneous collection of malignancies that originate from cells that can secrete hormones ( Latteyer et al. 2016 ). These are generally found in the tissues of the endocrine system, such as the thyroid

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A Perren
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S Schmid
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T Locher
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P Saremaslani
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C Bonvin
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P U Heitz
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P Komminoth
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endocrine tumors have been conducted (with the exception of thyroid tumors), although there are several indications pointing towards a possible role of BRAF in this type of tumor also. First, like melanomas ( Dupin & Le Douarin 2003 ), a subset of endocrine

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Arthur Varoquaux Department of Radiology, Conception Hospital, Aix-Marseille University, Marseille, France

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Electron Kebebew Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Fréderic Sebag Department of Endocrine Surgery, Conception Hospital, Aix-Marseille University, Marseille, France

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Katherine Wolf Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA

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Jean-François Henry Department of Endocrine Surgery, Conception Hospital, Aix-Marseille University, Marseille, France

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA

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David Taïeb Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France

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third epibranchial placode (nodose placode) ( Baker 2005 ). Vagal paragangliomas Tumor origin and molecular genetics Vagus nerve paraganglia belong to the family of parasympathetic paraganglia. Members act as chemoreceptors and are involved

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Cuiqi Zhou Pathology, Departments of

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Yunguang Tong Pathology, Departments of

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Kolja Wawrowsky Pathology, Departments of

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Serguei Bannykh Pathology, Departments of

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Ines Donangelo Pathology, Departments of

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Shlomo Melmed Pathology, Departments of

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-time PCR (A and B); Oct-1 and hPTTG1 protein levels were measured by western blot (C and D). Oct-1 and hPTTG1 are concordantly expressed in endocrine tumors and colon cancers hPTTG1 is overexpressed in multiple human tumors including pituitary, breast, and

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Thomas J Giordano Divisions of Anatomic Pathology and Molecular & Genomic Pathology, Departments of Pathology and Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA

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of tumor classification schemes. Together with the identification of novel genetic alterations, these results have profound implications for the treatment of cancer patients. Tumors of endocrine organs are similarly genomic diseases. Compared to

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Yasuhiko Nagano
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Do Ha Kim
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Li Zhang
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Jill A White
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James C Yao
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Stanley R Hamilton
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Asif Rashid
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Introduction Pancreatic endocrine tumors (PETs) are uncommon, mostly well-differentiated and indolent neuroendocrine neoplasms, with an age-adjusted annual incidence of <1 per 100 000 ( Buchanan et al. 1986 ). The molecular

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Y M H Jonkers
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S M H Claessen
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A Perren
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A M Schmitt
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L J Hofland
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W de Herder
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R R de Krijger
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A A J Verhofstad
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A R Hermus
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J A Kummer
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B Skogseid
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M Volante
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A C Voogd
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F C S Ramaekers
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E J M Speel
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Introduction The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict on the basis of their histological features. The presence of metastases is generally accepted to be the only definitive feature of

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