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Isadora Ramos-Andrade Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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João Moraes Redox Biology Laboratory Programa de Pesquisa em Farmacologia e Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

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Renata Machado Brandão-Costa Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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Simone Vargas da Silva Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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Antônio de Souza Serviço de Cirurgia Plástica, Departamento de Cirurgia Geral, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

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César da Silva Serviço de Cirurgia Plástica, Departamento de Cirurgia Geral, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

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Mariana Renovato-Martins Laboratory of Inflammation and Metabolism, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brasil

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Christina Barja-Fidalgo Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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. 2018 ). Along with the AT release of adipokines that may contribute to tumor progression, extracellular vesicles (EVs) derived from obese AT also play a role in this scenario ( Robado de Lope et al. 2018 ). EVs are small membrane vesicles coated

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Yu-Ling Tai Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

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Chun-Jung Lin Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Tsai-Kun Li Department and Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

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Tang-Long Shen Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

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Jer-Tsong Hsieh Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Benjamin P C Chen Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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isolation, storage, recovery, and the characterization from biofluids, such as plasma, serum, or urine, need to be optimized and standardized for clinical applications. The International Society for Extracellular Vesicles recently provided guidelines for EV

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Ophélie Delcorte CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Julie Craps FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Siam Mahibullah CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Catherine Spourquet CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Ludovic D’Auria Neurochemistry group, Institute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium

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Patrick Van Der Smissen PICT Platform, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Chantal Dessy FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Etienne Marbaix CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Michel Mourad Surgery and Abdominal Transplantation Division, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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Christophe E Pierreux CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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various malignancies, including PTC ( Khatami & Tavangar 2018 , Rappa et al. 2019 , Toraih et al. 2021 ). Special attention was paid to small non-coding RNAs, micro-RNAs (miRNAs), and small lipid bilayer-enclosed extracellular vesicles (EVs), both

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Mona Alharbi Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane Queensland, Australia

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Felipe Zuñiga Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile

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Omar Elfeky Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane Queensland, Australia

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Dominic Guanzon Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane Queensland, Australia

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Andrew Lai Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane Queensland, Australia

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Gregory E Rice Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane Queensland, Australia
Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
Perinatology Research Branch, NICHD/NIH, Wayne State University, Detroit, Michigan, USA

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Lewis Perrin Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia
Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, Queensland, Australia

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John Hooper Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia
Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, Queensland, Australia

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Carlos Salomon Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane Queensland, Australia
Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile
Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

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and metastasis. At the beginning, cancer cells activate the endogenic oncogenic pathways and prompt the cells to proliferate in their local niches. Nevertheless, at some point, these cells recruit endogenous secretions, such as extracellular vesicles

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Luca Varinelli Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Dario Caccia Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Chiara C Volpi Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Claudio Caccia Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Maida De Bortoli Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Elena Taverna Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Ambra V Gualeni Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Valerio Leoni Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Annunziata Gloghini Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Giacomo Manenti Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Italia Bongarzone Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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-tubulin was used as loading control. Western blots analysis were performed in triplicate. (B) Extracellular MIF was endocytosed in vesicle-like structures via CD74. Cells were incubated with 400 ng/ml Alexa 546 MIF for 30 and 60 min at 37 °C. Negligible

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Lei Qiao Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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Chao Dong Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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Wenlei Jia Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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Gang Sun Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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). Exosomes are extracellular vesicles (diameter 30–150 nm) secreted by cells with various biological functions ( Mears et al. 2004 , Sharma et al. 2016 ). Their involvement in intercellular communication has been widely depicted by delivering signaling

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Catalina Simion Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA

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Maria Elvira Cedano-Prieto Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA

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Colleen Sweeney Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA

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tail ( Fig. 1 ). LRIGs show homology in their extracellular domains and also in the juxtamembrane portion of their cytoplasmic domains. The remainder of the cytoplasmic domain diverges significantly amongst LRIGs ( Abraira et al . 2010 ) and may impart

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Himisha Beltran Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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Francesca Demichelis Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy

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). Extracellular vesicles (EVs) derived from metastatic tumor cells can also be detected in the circulation in men with CRPC, including those that are CTC-negative, and may carry tumor-associated proteins that can be quantified and tracked serially ( Gerdtsson et

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B Kwabi-Addo Department of Pathology, Baylor College of Medicine and Michael E DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA

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M Ozen Department of Pathology, Baylor College of Medicine and Michael E DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA

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M Ittmann Department of Pathology, Baylor College of Medicine and Michael E DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA

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transported across the plasma membrane ( Schafer et al. 2004 ) and/or can be released by extracellular vesicle shedding ( Taverna et al. 2003 ). FGF7 is present at approximately 28 ng/g wet weight in normal prostate ( Giri et al. 1999 a ). FGF7 contains

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Françoise Galland Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Ludovic Lacroix Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Patrick Saulnier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Philippe Dessen Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Geri Meduri Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Michèle Bernier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Stéphane Gaillard Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Jean Guibourdenche Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Thierry Fournier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Danièle Evain-Brion Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Jean Michel Bidart Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Philippe Chanson Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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melanosomes, smooth endoplasmic reticulum, recycling endosomes, neurotransmitter vesicles, mRNA ( Reck-Peterson et al . 2000 , Langford 2002 , Salerno et al . 2008 ), and neuroendocrine vesicles ( Rudolf et al . 2003 ). A role for MYO5A in tumor cell

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