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Misu Lee Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Amelie Lupp Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Nigel Mendoza Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Niamh Martin Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Rudi Beschorner Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Jürgen Honegger Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Jürgen Schlegel Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Talia Shively Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Elke Pulz Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Stefan Schulz Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Federico Roncaroli Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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Natalia S Pellegata Institute of Pathology, Department of Pharmacology and Toxicology, Departments of Neurosurgery, Medicine, Department of Neuropathology, Department of Neurosurgery, Institute of Pathology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

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the effect of pasireotide on regrowth of clinically non-functioning pituitary adenomas (NFPAs) ( www.ClinicalTrials.gov ; identifier NCT01620138). Gonadotroph pituitary adenomas (GPAs) account for approximately 35% of all pituitary tumors. They are

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Odelia Cooper
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George Vlotides Department of Medicine, Department of Medicine II, Department of Biomedical Science and Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, Pituitary Center, Cedars-Sinai Medical Center, Academic Affairs, Room 2015, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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Hidenori Fukuoka
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Mark I Greene Department of Medicine, Department of Medicine II, Department of Biomedical Science and Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, Pituitary Center, Cedars-Sinai Medical Center, Academic Affairs, Room 2015, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
Department of Medicine, Department of Medicine II, Department of Biomedical Science and Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, Pituitary Center, Cedars-Sinai Medical Center, Academic Affairs, Room 2015, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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Shlomo Melmed
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expression and function in gonadotroph adenomas. Overall, 75% of the 56 non-functioning adenomas tested express EGF either by IHC or by RT-PCR with rates varying between 10 and 100% in different series ( Chaidarun et al . 1994 a , Kontogeorgos et al . 1996

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Iain R Thompson Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Annisa N Chand Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Peter J King Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Olaf Ansorge Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Niki Karavitaki Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Ceri Alexander Jones Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Dolkun Rahmutula Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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David G Gardner Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Vladimir Zivkovic Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Caroline P Wheeler-Jones Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Imelda M McGonnell Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Márta Korbonits Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Richard A Anderson Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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John A H Wass Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Alan S McNeilly Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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Robert C Fowkes Endocrine Signalling Group, Developmental Biology Research Group, Department of Endocrinology, Neuropathology Department, Department of Endocrinology, School of Medicine, Department of Medicine, Medical Research Council Human Reproductive Sciences Unit, Veterinary Basic Sciences

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gonadotroph and somatotroph adenoma paraffin-fixed samples were sectioned to 4 μm for analysis. Paraffin embedding was removed with Histoclear before subjecting the sections to antigen retrieval and immunohistochemistry for GC-B using a rabbit polyclonal

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Graeme B Bolger Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Department of Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama, USA

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Mariana F Bizzi Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Sergio V Pinheiro Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Giampaolo Trivellin Center for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK

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Lisa Smoot Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

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Mary-Ann Accavitti Department of Microbiology and Immunology, University of Alabama at Birmingham, Birmingham, Alabama, USA

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Márta Korbonits Center for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK

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Antonio Ribeiro-Oliveira Jr Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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analysis of somatotroph, corticotroph, lactotroph, and clinically nonfunctioning gonadotroph adenomas as well as normal pituitary tissue. Normal pituitary architecture was evaluated by reticulin staining. After deparaffinization and hydrating procedures

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Françoise Galland Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Ludovic Lacroix Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Patrick Saulnier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Philippe Dessen Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Geri Meduri Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Michèle Bernier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Stéphane Gaillard Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Jean Guibourdenche Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Thierry Fournier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Danièle Evain-Brion Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Jean Michel Bidart Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Philippe Chanson Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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features. Most NFPAs are gonadotroph adenomas expressing steroidogenic factor 1 ( Asa et al . 1996 , Al-Shraim & Asa 2006 ), required for differentiation of gonadotroph cells, and producing follicle-stimulating hormone (FSH)β and/or luteinizing hormone

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K Revill
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K J Dudley
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R N Clayton
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A M McNicol Human Disease and Genomics Group, Molecular and Cellular Pathology, School of Medicine, Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, Staffordshire ST4 7QB, UK

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W E Farrell
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-localize with ∼40% of somatotrophs, ∼30% of corticotrophs, ∼50% of thyrotrophs, ∼30% of lactotrophs and ∼20% of gonadotrophs. NNAT expression status in pituitary adenomas A total of 47 pituitary adenomas were analysed by real-time RT-qPCR for NNAT transcript

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Audrey Ziverec Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Marie Chanal Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Perrine Raymond Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Mirela Diana Ilie Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France
Endocrinology Department, “C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania

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Dario De Alcubierre Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Arja Pasternack Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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Olli Ritvos Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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Gerald Raverot Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France
Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France
Department of Endocrinology, Reference center for rare pituitary disease (HYPO), Groupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France

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Philippe Bertolino Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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.07.009 ) Chesnokova V Zonis S Wawrowsky K Tani Y Ben-Shlomo A Ljubimov V Mamelak A Bannykh S Melmed S 2012 Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth . Molecular Endocrinology 26 2092 – 2103 . ( https

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Cuong V Duong
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Richard D Emes Institute of Science and Technology in Medicine, School of Veterinary Medicine and Science, Keele University School of Medicine, Stoke‐on‐Trent, Staffordshire ST4 7QB. UK

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Frank Wessely Institute of Science and Technology in Medicine, School of Veterinary Medicine and Science, Keele University School of Medicine, Stoke‐on‐Trent, Staffordshire ST4 7QB. UK

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Kiren Yacqub-Usman
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Richard N Clayton
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William E Farrell
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epimutations, methylation-mediated silencing of the MEG3 gene is a frequent finding in pituitary adenomas of gonadotroph origin whereas methylation-mediated silencing of the p16 gene ( CDKN2A ) is infrequent in somatotrophinomas but is a common finding in

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Maria P Yavropoulou Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Marina Tsoli Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Konstantinos Barkas Department of Neurosurgery, General Hospital of Nikaia-Peiraia, Agios Panteleimon, Athens, Greece

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Gregory Kaltsas Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Ashley Grossman Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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factor 1; TPIT, T-box family member TBX19; TSH, thyroid stimulating hormone; WHO, World Health Organization. Subtypes of non-functioning PitNETs Non-functioning-silent gonadotroph adenomas Silent gonadotroph adenomas (sGAs) comprise the

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Annamaria Colao Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Carolina Di Somma Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Rosario Pivonello Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Antongiulio Faggiano Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Gaetano Lombardi Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Silvia Savastano Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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secretion from gonadotroph adenomas by repetitive administration of a gonadotropin-releasing hormone antagonist . Journal of Clinical Endocrinology and Metabolism 71 92 – 97 . Dekkers OM Hammer S de Keizer RJ Roelfsema F Schutte PJ Smit JW

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