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Mark Daniel Masonic Cancer Center, University of Minnesota
Graduate Program in Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, Minnesota, USA

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Todd P Knutson University of Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, USA

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Jamie M Sperger Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Yingming Li Masonic Cancer Center, University of Minnesota

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Anupama Singh Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Charlotte N Stahlfeld Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Courtney Passow University of Minnesota Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA

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Benjamin Auch University of Minnesota Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA

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Joshua M Lang Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Scott M Dehm Masonic Cancer Center, University of Minnesota
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA

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are challenging and a high burden for patients. As a result, assessing CRPC genomic alterations via blood-based 'liquid biopsy' is an attractive alternative. One common liquid biopsy approach involves the examination of circulating tumor cells (CTCs

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0157
Volume/Issue:
Volume 28: Issue 9
Restricted access
Walid Zeyghami Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Marie-Louise Uhre Hansen Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Kathrine Kronberg Jakobsen Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Christian Groenhøj Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Endocrinology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark

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Christian von Buchwald Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark

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Christoffer Holst Hahn Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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for MTC ( Van Veelen et al. 2009 ). Liquid biopsy has been suggested as a new and noninvasive way to diagnose cancer, monitor treatment response, and aid in cancer surveillance ( Payne et al. 2018 ). Liquid biopsies consist of isolating entities

Article Type:
Systematic Review
DOI:
https://doi.org/10.1530/ERC-23-0002
Volume/Issue:
Volume 30: Issue 12
Free access
Karel Pacak Section of Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Mark Kidd WREN Laboratories, Branford, Connecticut, USA

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Leah Meuter Section of Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Irvin M Modlin Gastroenterological and Endoscopic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA

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. A liquid biopsy approach (e.g. using blood as opposed to tissue) has diagnostic value and can, in addition, provide relevant biological information in respect of the presence of a tumor and its behavior. The NETest is a multigenomic mRNA liquid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0216
Volume/Issue:
Volume 28: Issue 11
Restricted access
Ophélie Delcorte CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Julie Craps FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Siam Mahibullah CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Catherine Spourquet CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Ludovic D’Auria Neurochemistry group, Institute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium

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Patrick Van Der Smissen PICT Platform, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Chantal Dessy FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Etienne Marbaix CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Michel Mourad Surgery and Abdominal Transplantation Division, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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Christophe E Pierreux CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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reduce overtreatment, the discovery and the development of more accurate diagnostic tools are a necessity ( Oblak et al. 2021 ). Recently, liquid biopsy has emerged as a promising opportunity to develop non-invasive and sensitive biomarkers for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0343
Volume/Issue:
Volume 29: Issue 7
Restricted access
Alexa Childs UCL Cancer Institute, University College London, London, UK

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Christopher D Steele UCL Cancer Institute, University College London, London, UK

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Clare Vesely UCL Cancer Institute, University College London, London, UK

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Francesca M Rizzo UCL Cancer Institute, University College London, London, UK

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Leah Ensell UCL Cancer Institute, University College London, London, UK

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Helen Lowe UCL Cancer Institute, University College London, London, UK

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Pawan Dhami UCL Cancer Institute, University College London, London, UK

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Heli Vaikkinen UCL Cancer Institute, University College London, London, UK

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Tu Vinh Luong Department of Histopathology, Royal Free London NHS Foundation Trust, London, UK

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Lucia Conde UCL Cancer Institute, University College London, London, UK

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Javier Herrero UCL Cancer Institute, University College London, London, UK

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Martyn Caplin Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK

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Christos Toumpanakis Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK

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Christina Thirlwell UCL Cancer Institute, University College London, London, UK
Department of Oncology, Royal Free London NHS Foundation Trust, London, UK

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John A Hartley UCL Cancer Institute, University College London, London, UK

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Nischalan Pillay Research Department of Pathology, Cancer Institute, University College London, London, UK
Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK

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Tim Meyer UCL Cancer Institute, University College London, London, UK
Department of Oncology, Royal Free London NHS Foundation Trust, London, UK

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. Furthermore, characterization of single-circulating tumor cells (CTCs) as part of a minimally invasive 'liquid biopsy' provides an opportunity to explore tumor biology and identify therapeutic targets. The first clinical applications of CTCs focused on

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0179
Volume/Issue:
Volume 28: Issue 9
Open access
Masaki Shiota Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Shusuke Akamatsu Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Shigehiro Tsukahara Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Shohei Nagakawa Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Takashi Matsumoto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Masatoshi Eto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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patients. Actually, recent analysis by liquid biopsy demonstrated that co-occurrence of AR mutation and amplification was observed in 5 (33.3%) among 15 clinical CRPC patients with AR mutation, in addition to co-occurrence with other genomic alterations

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0140
Volume/Issue:
Volume 29: Issue 10
Free access
Kristina Warton Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia

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Kate L Mahon Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia
Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia

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Goli Samimi Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia

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limitations to obtaining sequence information from solid cancers: due to the clonal evolution and heterogeneity of a tumor, a single biopsy may not represent the diversity of DNA changes present; metastasized disease may be difficult to identify and access

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0369
Volume/Issue:
Volume 23: Issue 3
Open access
Karin Jennbacken Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Tajana Tešan Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Wanzhong Wang Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Heléne Gustavsson Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Jan-Erik Damber Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Karin Welén Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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to cell injection via the abdominal incision. The animal experiments were discontinued after 9 weeks. Tumors were harvested, and one part was fixed in formalin for paraffin embedding and the other part was frozen in liquid nitrogen and stored at −80

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0015
Volume/Issue:
Volume 17: Issue 2
Free access
Vera Cappelletti
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Luigi Celio
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Emilio Bajetta
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Arianna Allevi
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Raffaella Longarini
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Patrizia Miodini
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Raffaella Villa
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Alessandra Fabbri
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Luigi Mariani
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Riccardo Giovanazzi
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Emanuele Galante
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Marco Greco
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Maria Grazia Daidone
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(T2, T3, N0-1, M0) or locally advanced disease (T4b, N0-1, M0) entered the study. Tumor specimens for diagnosis and immunohistochemical assessment (ER-α, PgR) or molecular determinations (ER-β and ER-α mRNA) were obtained by 3–4 core needle biopsies

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00822
Volume/Issue:
Volume 11: Issue 4
Free access
C J Fabian
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B F Kimler
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M S Mayo
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S A Khan
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have previously had a biopsy exhibiting atypical ductal hyperplasia (ADH), ductal or lobular carcinoma in situ (DCIS, LCIS), or currently have an estimated 5-year Gail model risk of >1.67% ( Fisher et al. 1998 , Cuzick et al. 2002 , Hershman et

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01000
Volume/Issue:
Volume 12: Issue 2
Free access