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Teresa Gagliano Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Mariaenrica Bellio Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Erica Gentilin Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy
Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Daniela Molè Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Federico Tagliati Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Marco Schiavon Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Narciso Giorgio Cavallesco Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Luigi Gaetano Andriolo Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Maria Rosaria Ambrosio Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Federico Rea Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Ettore degli Uberti Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy
Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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Maria Chiara Zatelli Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy
Section of Endocrinology, Laboratorio in Rete del Tecnopolo ‘Tecnologie delle Terapie Avanzate’ (LTTA), Department of Cardiological, Department of Morphology, Department of Medical Sciences, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

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. 2011 ), providing the basis for the development of specific mTOR inhibitors as new therapeutic tools for NETs ( Dong et al . 2012 ), including BCs ( Dong & Yao 2011 ). Despite their potential efficacy as anticancer agents, mTOR inhibitors have

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0042
Volume/Issue:
Volume 20: Issue 4
Free access
Maria Chiara Zatelli Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

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Giuseppe Fanciulli Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

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Pasqualino Malandrino Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

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Valeria Ramundo Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

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Antongiulio Faggiano Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

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Annamaria Colao Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

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on behalf of NIKE Group
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target of rapamycin (mTOR) inhibitors are emerging among the new targeted therapies as powerful tools in NET medical therapy. mTOR is a serine/threonine protein kinase found in two major complexes: mTORC1 and mTORC2. mTORC1 is sensitive to the inhibition

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0413
Volume/Issue:
Volume 23: Issue 3
Free access
Maria Cristina De Martino Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Peter M van Koetsveld Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Richard A Feelders Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Diana Sprij-Mooij Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Marlijn Waaijers Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Steven W J Lamberts Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Wouter W de Herder Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Annamaria Colao Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Rosario Pivonello Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Leo J Hofland Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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et al . 2010 ). mTOR inhibitors may exert their antitumor effects directly by inhibiting cell growth and proliferation and indirectly by inhibiting tumor angiogenesis ( Guertin & Sabatini 2007 , LoPiccolo et al . 2008 ). Presently, many clinical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0270
Volume/Issue:
Volume 19: Issue 3
Free access
Simona Falletta Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Stefano Partelli Pancreatic Surgery Unit, Pancreas Translational and Research Institute, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy

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Corrado Rubini Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

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Dominik Nann Institut fur Pathologie, University of Bern, Bern, Switzerland

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Andrea Doria Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

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Ilaria Marinoni Institut fur Pathologie, University of Bern, Bern, Switzerland

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Vanessa Polenta Pancreatic Surgery Unit, Pancreas Translational and Research Institute, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy

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Carmelina Di Pasquale Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Ettore degli Uberti Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Aurel Perren Institut fur Pathologie, University of Bern, Bern, Switzerland

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Massimo Falconi Pancreatic Surgery Unit, Pancreas Translational and Research Institute, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy

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Maria Chiara Zatelli Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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responsiveness to mTOR inhibitors ( Righi et al . 2010 , Qian et al. 2013 , Zatelli et al . 2016 ). The mTOR inhibitor has recently shown antitumor activity in advanced, well-differentiated and moderately differentiated P-NETs ( Yao et al . 2011 ), but

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0329
Volume/Issue:
Volume 23: Issue 11
Free access
K Yu Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road, Pearl River, New York 10965, USA.

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L Toral-Barza Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road, Pearl River, New York 10965, USA.

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C Discafani Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road, Pearl River, New York 10965, USA.

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W G Zhang Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road, Pearl River, New York 10965, USA.

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J Skotnicki Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road, Pearl River, New York 10965, USA.

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P Frost Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road, Pearl River, New York 10965, USA.

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J J Gibbons Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road, Pearl River, New York 10965, USA.

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The mammalian target of rapamycin (mTOR) is a central regulator of G1 cell cycle protein synthesis that precedes commitment to normal cellular replication. We have studied the effect of cell cycle inhibitor-779 (CCI-779), a rapamycin ester that inhibits mTOR function, on the proliferation of a panel of breast cancer cell lines. Six of eight lines studied were sensitive (IC(50)< or = 50 nM) and two lines were resistant (IC(50)>1.0 microM) to CCI-779. Sensitive lines were estrogen dependent (MCF-7, BT-474, T-47D), or lacked expression of the tumor suppressor PTEN (MDA-MB-468, BT-549), and/or overexpressed the Her-2/neu oncogene (SKBR-3, BT-474). Resistant lines (MDA-MB-435, MDA-MB-231) shared none of these properties. CCI-779 (50 nM) inhibited mTOR function in both a sensitive and a resistant line. In nu/nu mouse xenografts, CCI-779 inhibited growth of MDA-MB-468 (sensitive) but not MDA-MB-435 resistant tumors. Treatment of sensitive lines with CCI-779 resulted in a decrease in D-type cyclin and c-myc levels and an increase in p27(kip-1) levels. There was good correlation between activation of the Akt pathway and sensitivity to CCI-779. Amplification of mTOR-regulated p70S6 kinase, which is downstream of Akt, may also have conferred CCI-779 sensitivity to MCF-7 cells. Taken together, the data suggest that mTOR may be a good target for breast cancer therapy, especially in tumors with Akt activation resulting from either growth factor dependency or loss of PTEN function.

Article Type:
Abstract
Volume/Issue:
Volume 8: Issue 3
Free access
Luisella Righi
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Marco Volante
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Ida Rapa
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Veronica Tavaglione
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Frediano Inzani Division of Pathology, Division of Pathology, National Cancer Institute and University of Milan, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043 Orbassano, Torino, Italy

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Giuseppe Pelosi Division of Pathology, Division of Pathology, National Cancer Institute and University of Milan, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043 Orbassano, Torino, Italy

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Mauro Papotti
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growth factor (VEGF) pathway, and inhibitors of the mammalian target of rapamycin (mTOR), which have shown promising activity in recent clinical studies ( Duran et al . 2007 , Kulke 2007 , Yao et al . 2008 , 2010 ). mTOR is a serine threonine kinase

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0157
Volume/Issue:
Volume 17: Issue 4
Free access
Atsuko Kasajima Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Marianne Pavel Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Silvia Darb-Esfahani Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Aurelia Noske Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Albrecht Stenzinger Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Hironobu Sasano Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Manfred Dietel Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Carsten Denkert Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Christoph Röcken Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Bertram Wiedenmann Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Wilko Weichert Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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( Modlin et al . 2008 ), therefore novel treatment strategies for these tumours are still urgently needed. Recently, the mammalian target of rapamycin (mTOR) inhibitors temsirolimus ( Rini 2008 ) and everolimus ( Sánchez-Fructuoso 2008 ) have entered late

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0126
Volume/Issue:
Volume 18: Issue 1
Free access
Matti L Gild Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Iñigo Landa Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Mabel Ryder Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology
Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Ronald A Ghossein Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Jeffrey A Knauf Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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James A Fagin Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology
Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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also has effects on mammalian target of rapamycin (mTOR), has been shown to inhibit growth and induce apoptosis of the MTC cell line TT ( Kunnimalaiyaan et al . 2006 , Ball et al . 2007 ). Recently, novel natural compounds called withanolides have

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0085
Volume/Issue:
Volume 20: Issue 5
Free access
Rhonda L Bitting Divisions of Medical Oncology and Urology, Duke Cancer Institute, Duke University, DUMC Box 102002, Durham, North Carolina 27710, USA

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Andrew J Armstrong Divisions of Medical Oncology and Urology, Duke Cancer Institute, Duke University, DUMC Box 102002, Durham, North Carolina 27710, USA

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pathway inhibitors as single agents or in combination with other agents in the currently evolving treatment landscape of CRPC. The PI3K/Akt/mTOR signaling pathway The PI3K/Akt/mTOR signaling pathway has a diverse array of functions, including the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0394
Volume/Issue:
Volume 20: Issue 3
Free access
Alessia Di Florio Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Laura Adesso Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Simona Pedrotti Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Gabriele Capurso Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Emanuela Pilozzi Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Vincenzo Corbo Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Aldo Scarpa Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Raffaele Geremia Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Gianfranco Delle Fave Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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Claudio Sette Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

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factor eIF4B and the translation inhibitor 4E-BP1 ( Hay & Sonenberg 2004 ). The implication of mTOR in proliferation control has stimulated studies aimed at interfering with its activity in cancer cells ( Meric-Bernstam & Gonzalez-Angulo 2009

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0153
Volume/Issue:
Volume 18: Issue 5
Free access