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genetic data, these tumours are being diagnosed by endocrinologists and oncologists, but much of the published literature is in more specialised ENT or surgical journals. We think that it will be useful to survey current data on the management of these
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, integrative treatments, procedures, and NET-directed treatments in people with symptom-related NET. Treatment type (✓ if relatively specific to palliation of NET) Intervention Typical indication in people with NET Symptom management
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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American Multiple Endocrine Neoplasia Support (AMENSupport), Maryville, Tennessee, USA
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Departments of Intelligent Systems Engineering and Informatics, Indiana University, Bloomington, Indiana, USA
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) were present, as were representatives from the pharmaceutical industry and the Neuroendocrine Tumor Research Foundation (NETRF). In a case-based approach, participants addressed early detection, surveillance, prognostic factors and management of
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: LN metastases were present in 15% of patients with tumours ≤1.0 cm in diameter, 47% with tumours >1 cm but ≤2 cm in diameter and 86% with tumours >2 cm in diameter ( Mullen & Savarese 2011 ). Treatment The management of aNENs depends on the size and
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is technically impossible, a repeat noninvasive localization work-up after 2–6 months is a more attractive and preferable choice. Management After precise localization, surgical removal of the tumor should follow with the expectation that all symptoms
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Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
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, ranging between 10% and 38% on CT imaging and 4–20% on MRI compared to the incidence of macroadenomas (range between 0.16% on MRI and 0.3% on CT) ( Freda et al. 2011 ). The management of NFpitNETs includes replacement hormonal therapy in the presence
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improve diagnosis, prognosis evaluation, and treatment. This review will summarize the advances in the molecular mechanisms of adrenocortical tumors development that have recently been made and the current clinical management of ACC
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. Management should be guided by the Consensus Guidelines for Management of NETs, for example those produced by the European Neuroendocrine Tumour Society (ENETS). In low- and intermediate-grade metastatic midgut NETs, somatostatin analogues are the mainstay of
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Department of Internal Medicine and Medical Specialties, Department of Internal Medicine, Department of Health Sciences, University of Rome ‘Sapienza’, Viale del Policlinico 155, 00161 Rome, Italy
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appropriate, cost-effective management of the current generation of DTCs. Table 1 Paradigm shifts in the management of differentiated thyroid cancers Old paradigms Current paradigms a Future paradigms What is the appropriate operation for DTCs? Total
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data by panels of clinical and research experts from nearly all specialties involved in the care of patients with thyroid cancer. Most guidelines are updated periodically to reflect additional data that influence clinical management over time. However