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Cristina Capatina Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK

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Georgia Ntali Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK

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Niki Karavitaki Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK

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Ashley B Grossman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK

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genetic data, these tumours are being diagnosed by endocrinologists and oncologists, but much of the published literature is in more specialised ENT or surgical journals. We think that it will be useful to survey current data on the management of these

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Jaydira Del Rivero Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA

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Josh Mailman NorCal CarciNET Community, Oakland, California, USA

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Michael W Rabow Department of Internal Medicine, Division of Palliative Medicine, University of California, San Francisco, San Francisco, California, USA

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Jennifer A Chan Harvard Medical School, Program in Carcinoid and Neuroendocrine Tumors, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Sarah Creed Good Shepherd Community Care, Harvard Kennedy School, Natick, Massachusetts, USA

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Hagen F Kennecke Providence Cancer Institute Franz Clinic, Portland Providence Medical Center, Portland, Oregon, USA

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Janice Pasieka Department of Surgery, Section of General Surgery, University of Calgary, Cumming School of Medicine, Calgary, Canada

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Jennifer Zuar Department of Internal Medicine, Division of Geriatrics and Palliative Medicine, Alpert Medical School, Providence, Rhode Island, USA

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Simron Singh Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Lauren Fishbein Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA

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, integrative treatments, procedures, and NET-directed treatments in people with symptom-related NET. Treatment type (✓ if relatively specific to palliation of NET) Intervention Typical indication in people with NET Symptom management

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C R C Pieterman Section of Surgical Endocrinology, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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S M Sadowski Endocrine Surgery, Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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J E Maxwell Department of Surgical Oncology, University of Texas MD Anderson Cancer Center

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M H G Katz Department of Surgical Oncology, University of Texas MD Anderson Cancer Center

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K E Lines Academic Endocrine Unit, Radcliffe Department of Medicine, OCDEM, University of Oxford, Oxford, UK

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C M Heaphy Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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A Tirosh Neuroendocrine Tumors Service, Division of Endocrinology, Metabolism and Diabetes, The Chaim Sheba Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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J E Blau Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

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N D Perrier Section of Surgical Endocrinology, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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M A Lewis Gastrointestinal Oncology, Intermountain Healthcare, Murray, Utah, USA
American Multiple Endocrine Neoplasia Support (AMENSupport), Maryville, Tennessee, USA

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J P Metzcar Association of Multiple Endocrine Neoplasia Disorders (AMEND), Bloomington, Indiana, USA
Departments of Intelligent Systems Engineering and Informatics, Indiana University, Bloomington, Indiana, USA

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D M Halperin Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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R V Thakker Academic Endocrine Unit, Radcliffe Department of Medicine, OCDEM, University of Oxford, Oxford, UK

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G D Valk Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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) were present, as were representatives from the pharmaceutical industry and the Neuroendocrine Tumor Research Foundation (NETRF). In a case-based approach, participants addressed early detection, surveillance, prognostic factors and management of

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Krystallenia I Alexandraki Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Gregory A Kaltsas Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Simona Grozinsky-Glasberg Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Eleftherios Chatzellis Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Ashley B Grossman Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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: LN metastases were present in 15% of patients with tumours ≤1.0 cm in diameter, 47% with tumours >1 cm but ≤2 cm in diameter and 86% with tumours >2 cm in diameter ( Mullen & Savarese 2011 ). Treatment The management of aNENs depends on the size and

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Asterios Karagiannis
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Dimitri P Mikhailidis Division of Endocrinology, Department of Clinical Biochemistry,, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece

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Vasilios G Athyros
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Faidon Harsoulis
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is technically impossible, a repeat noninvasive localization work-up after 2–6 months is a more attractive and preferable choice. Management After precise localization, surgical removal of the tumor should follow with the expectation that all symptoms

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Maria P Yavropoulou Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Marina Tsoli Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Konstantinos Barkas Department of Neurosurgery, General Hospital of Nikaia-Peiraia, Agios Panteleimon, Athens, Greece

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Gregory Kaltsas Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Ashley Grossman Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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, ranging between 10% and 38% on CT imaging and 4–20% on MRI compared to the incidence of macroadenomas (range between 0.16% on MRI and 0.3% on CT) ( Freda et al. 2011 ). The management of NFpitNETs includes replacement hormonal therapy in the presence

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Rossella Libè
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Amato Fratticci
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Jérôme Bertherat
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improve diagnosis, prognosis evaluation, and treatment. This review will summarize the advances in the molecular mechanisms of adrenocortical tumors development that have recently been made and the current clinical management of ACC

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Mohid S Khan Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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Martyn E Caplin Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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. Management should be guided by the Consensus Guidelines for Management of NETs, for example those produced by the European Neuroendocrine Tumour Society (ENETS). In low- and intermediate-grade metastatic midgut NETs, somatostatin analogues are the mainstay of

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Cosimo Durante
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Giuseppe Costante Department of Internal Medicine and Medical Specialties, Department of Internal Medicine, Department of Health Sciences, University of Rome ‘Sapienza’, Viale del Policlinico 155, 00161 Rome, Italy
Department of Internal Medicine and Medical Specialties, Department of Internal Medicine, Department of Health Sciences, University of Rome ‘Sapienza’, Viale del Policlinico 155, 00161 Rome, Italy

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Sebastiano Filetti
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appropriate, cost-effective management of the current generation of DTCs. Table 1 Paradigm shifts in the management of differentiated thyroid cancers Old paradigms Current paradigms a Future paradigms What is the appropriate operation for DTCs? Total

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Fadi Nabhan Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine, Wexner Medical Center, Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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Matthew D Ringel Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine, Wexner Medical Center, Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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data by panels of clinical and research experts from nearly all specialties involved in the care of patients with thyroid cancer. Most guidelines are updated periodically to reflect additional data that influence clinical management over time. However

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