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Zijie Feng Department of Cancer Biology Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Jian Ma Department of Cancer Biology Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania, Philadelphia, Pennsylvania, USA
State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

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Xianxin Hua Department of Cancer Biology Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Introduction In recent years, prevalence of neuroendocrine tumors is increasing ( Jiao et al. 2011 ), and the multiple endocrine neoplasia type 1 (MEN1) gene, which encodes protein menin, is genetically well characterized for its function in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0298
Volume/Issue:
Volume 24: Issue 10
Free access
Koen M A Dreijerink Department of Endocrinology VU University Medical Center, Amsterdam, The Netherlands

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H T Marc Timmers German Cancer Consortium (DKTK) partner site Freiburg German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany

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Myles Brown Department of Medical Oncology Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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Introduction In the 1997 paper reporting the positional cloning of the multiple endocrine neoplasia type 1 ( MEN1 ) gene, the authors proposed the name menin for its protein product. Chandrasekharappa and coworkers noted that analysis of the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0281
Volume/Issue:
Volume 24: Issue 10
Free access
C R C Pieterman Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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E B Conemans Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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K M A Dreijerink Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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J M de Laat Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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H Th M Timmers Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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M R Vriens Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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G D Valk Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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review are based on the experience of the authors and on an extensive search in PubMed. The following terms were used in the search string: ‘MEN1’ and all relevant synonyms OR ‘menin’ and all relevant synonyms. For lung NET, this search string was

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0482
Volume/Issue:
Volume 21: Issue 3
Free access
Razan Abou Ziki Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Romain Teinturier Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Yakun Luo Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Catherine Cerutti Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France

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Jean-Marc Vanacker Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France

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Coralie Poulard Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Thomas Bachelot Department of Medical Oncology, Centre Léon Bérard, Lyon, France

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Mona Diab-Assaf Faculty of Sciences II, Lebanese University Fanar, Beirut, Lebanon

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Isabelle Treilleux Département de Biopathologie, Centre Léon Bérard, Lyon, France

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Chang Xian Zhang Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Muriel Le Romancer Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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order to overcome resistance to endocrine therapy ( Miller et al. 2010 ). Menin, encoded by the MEN1 gene, is a multifaceted cofactor, interacting physically or functionally with numerous transcription and epigenetic factors, including Smad3, JunD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0337
Volume/Issue:
Volume 29: Issue 8
Restricted access
Z Hamze INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C Vercherat INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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A Bernigaud-Lacheretz INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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W Bazzi INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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R Bonnavion INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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J Lu INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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A Calender INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C Pouponnot INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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P Bertolino INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C Roche INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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R Stein INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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J Y Scoazec INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C X Zhang INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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M Cordier-Bussat INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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insulinoma and NETs research is to understand how the loss of appropriate expression of the Men1 gene product, MENIN, contributes to the development of these endocrine tumours ( Gracanin et al . 2009 ). MENIN is a protein that is ubiquitously expressed

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0164
Volume/Issue:
Volume 20: Issue 6
Free access
Hermine Mohr Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

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Natalia S Pellegata Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

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11q13 was identified as the gene responsible for the MEN1 syndrome ( Chandrasekharappa et al . 1997 , Lemmens et al . 1997 ). The encoded 610-aa long protein named Menin is a tumor suppressor, and tumors of MEN1 patients usually show loss

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0249
Volume/Issue:
Volume 24: Issue 10
Free access
Kreepa G Kooblall OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Victoria J Stokes OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Omair A Shariq OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Katherine A English OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Mark Stevenson OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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John Broxholme Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Benjamin Wright Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Helen E Lockstone Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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David Buck Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Endocrinology & Metabolism Department, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Israel

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Christopher J Yates OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Rajesh V Thakker OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK

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Kate E Lines OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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with MEN1 have pathogenic mutations in the MEN1 gene, which leads to loss of its encoded 610 amino acid tumour suppressor protein, menin ( Brandi et al. 2021 ). Pathogenic germline and somatic MEN1 mutations reported in both familial and sporadic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0045
Volume/Issue:
Volume 29: Issue 10
Open access
Kerong Shi Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 8C-101, Bethesda, Maryland 20892, USA

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Vaishali I Parekh Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 8C-101, Bethesda, Maryland 20892, USA

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Swarnava Roy Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 8C-101, Bethesda, Maryland 20892, USA

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Shruti S Desai Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 8C-101, Bethesda, Maryland 20892, USA

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Sunita K Agarwal Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 8C-101, Bethesda, Maryland 20892, USA

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Introduction In patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome, germline inactivating mutation in one copy of the MEN1 gene encoding menin predisposes to endocrine tumors of the parathyroids, anterior pituitary, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0077
Volume/Issue:
Volume 20: Issue 1
Free access
M Theodoropoulou Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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I Cavallari Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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L Barzon Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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D M D'Agostino Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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T Ferro Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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T Arzberger Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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Y Grübler Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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L Schaaf Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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M Losa Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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F Fallo Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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V Ciminale Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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G K Stalla Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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U Pagotto Max Planck Institute of Psychiatry, Neuroendocrinology Group, 80804 Munich, Germany. marily@mpipsykl.mpg.de

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Pituitary adenomas represent one of the key features of multiple endocrine neoplasia type 1. The gene involved in this syndrome (MEN1) is a putative tumor suppressor, that codes for a 610-amino acid nuclear protein termed 'menin'. Analyses of sporadic pituitary adenomas have so far failed to reveal MEN1 mutations or defects in MEN1 transcription in these tumors. In the present study we detected menin protein expression in a panel of normal and tumoral pituitary tissues, using a monoclonal antibody against the carboxy-terminus of menin. In the normal human pituitary gland, strong nuclear staining for menin was detectable in the majority of the endocrine cells of the anterior lobe, without a clear association with a particular hormone-producing type. In sporadic pituitary adenomas, menin expression was variable, with a high percentage of cases demonstrating a significant decrease in menin immunoreactivity when compared with the normal pituitary. Interestingly, metastatic tissues derived from one pituitary carcinoma had no detectable menin levels. Altogether, our data provide the first information regarding the status of menin expression in human normal and neoplastic pituitary as determined by immunohistochemistry (IHC).

Article Type:
Abstract
DOI:
https://doi.org/10.1677/erc.0.0110333
Volume/Issue:
Volume 11: Issue 2
Free access
Vincenzo Corbo ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Irene Dalai ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Maria Scardoni ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Stefano Barbi ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Stefania Beghelli ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Samantha Bersani ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy
ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Luca Albarello ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Claudio Doglioni ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Christina Schott ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Paola Capelli ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Marco Chilosi ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy
ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Letizia Boninsegna ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Karl-Friedrich Becker ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Massimo Falconi ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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Aldo Scarpa ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy
ARC-NET Research Center, Department of Pathology, Department of Pathology, Technische Universität München, Department of Surgical and Gastroenterological Sciences, University of Verona, Policlinico G.B. Rossi c/o Piastra Odontoiatrica, Piazzale L.A. Scuro, 10, 37134 Verona, Italy

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. 1998 , Gortz et al . 1999 , Jonkers et al . 2006 ). MEN1 gene encodes for menin, a 610 amino acid protein ( Chandrasekharappa et al . 1997 , Lemmens et al . 1997 ) that is ubiquitously expressed in adult tissues ( Chandrasekharappa et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0028
Volume/Issue:
Volume 17: Issue 3
Free access