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have demonstrated the role of miRNAs in physiologic and pathologic conditions, including evidence suggesting miRNA dysregulation in tumorigenesis ( Solomides et al . 2012 ). Among the many miRNAs dysregulated in cancer, miR-145 has been proposed to be
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Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA
The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
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The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
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The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
Center for Integrative Environmental Health Sciences (CIEHS), University of Louisville, Louisville, Kentucky, USA
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in TAM-resistant cell lines. We tested the hypothesis that A2B1 downregulates miRNAs that directly target PHGDH and PSAT1 , resulting in increased protein levels. We identified A2B1-regulated miRNAs, miR-145-5p and miR-424-5p, that directly target
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in DU145 and lowest levels in LNCaP cells ( Fig. 4 A, B, C, D, E, F, G and H). This prompted us to in silico explore the presence of androgen response elements (AREs) and ZEB2-binding sites in MIR200A and MIR200B genes. Figure 10 (A) miR200a and
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Division of Surgery, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
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, miR-145-3p and miR-139-5p to disrupt the miRNAs-mediated inhibition of VEGFA and VEGFC and inactivation of transforming growth factor (TGF)-β signaling. Collectively, our results provide experimental evidence regarding the clinical significance and
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Laboratory of Cellular and Molecular Biology, Department of Pathology, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 6C228, Baltimore, Maryland 21224, USA
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, miR-299 , let7d , miR-155 , miR-140 , miR-222 , miR-337 , miR-124a , miR-99a , miR-331 , miR-104 , miR-150 , miR-184 , miR-152 , miR-145 , miR-424 , miR-224 , miR-302c EOC cell lines versus normal Zhang et al . (2008) None
Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of
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miR-145 are two clustered miRs on chromosome 5q that are commonly downregulated in different tumor types, such as tumors of the colon, breast, and ovary ( Michael et al . 2003 , Iorio et al . 2005 , 2007 , Akao et al . 2007 , Chen et
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Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
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.6 0.04581073 miR-548 0.5 0.006746057 miR-191-5p 0.5 0.04581073 miR-145-5p b,c −0.7 0.018028326 miR-1825 c −0.5 0.04792938 miR-1233 c −0.8 0.00034256 miR-331-5p c −0.7 0.0143562 miR-1 c −0.8 0
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Department of Hematology, Department of Experimental Oncology, Oncology and Molecular Medicine, Istituto Superiore Sanità, viale Regina Elena 299, 00161 Rome, Italy
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↑ ↓ ↓ miR-125b ↓ ↓ ↓ ↑ miR-128 ↓ ↓ miR-141 ↑ ↑ miR-143 ↓ ↓ miR-145 ↓ ↓ miR-146 ↑ ↓ miR-148 ↑ ↓ miR-16 ↑ ↓ ↓ ↓ miR-181
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Department of Surgery and Cancer, Cardiff University School of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Du Cane Road, London W12 0NN, UK
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et al . 2008 , Rokhlin et al . 2008 , Tong et al . 2008 ). Of these, miR-101, miR-145, miR-34a, miR-182, miR-375, miR-181a, miR-92b and miR-125 were upregulated by androgen, whilst miR-16, miR-126*, miR-23b, miR-100, miR-222, miR-133a, miR-499 and
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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subjects and ACA or ACC patients. We demonstrate a strong predictive value of low miR-195 and high miR-483-5p circulating levels for the diagnosis and prognosis of aggressive ACC (aACC). Materials and methods Patients and clinical samples Informed signed