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Zhe Wang, Ke Ma, Steffie Pitts, Yulan Cheng, Xi Liu, Xiquan Ke, Samuel Kovaka, Hassan Ashktorab, Duane T Smoot, Michael Schatz, Zhirong Wang, and Stephen J Meltzer

functional assays using interference and overexpression of circNF1 revealed that circNF1 promotes cell proliferation. Finally, circNF1 functioned as a miR-16 sponge, derepressing the miR-16 target genes MAP7 and AKT3 . We conclude that circNF1

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Darrell Green, Irina Mohorianu, Iain McNamara, Tamas Dalmay, and William D Fraser

variability in the number of reads assigned to either miRNAs or tRNA fragments in the control samples (when compared to inbred genetic models such as mice and fruit flies where variability is minimal). We identified a low expression of miR-16 in PDB compared

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Goswin Y Meyer-Rochow, Nicole E Jackson, John V Conaglen, Denis E Whittle, Muthusamy Kunnimalaiyaan, Herbert Chen, Gunnar Westin, Johanna Sandgren, Peter Stålberg, Elham Khanafshar, Daniel Shibru, Quan-Yang Duh, Orlo H Clark, Electron Kebebew, Anthony J Gill, Rory Clifton-Bligh, Bruce G Robinson, Diana E Benn, and Stan B Sidhu

cancer came from the observation that the most common deletions in human chronic lymphocytic leukaemia (CLL) occur in the 13q14 chromosomal region ( Calin et al . 2002 ). Two miRNAs (miR-15 and miR-16) are located in this region and have been found to be

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Neetu Dahiya and Patrice J Morin

& Lai 2008 ). A possible link between miRs and cancer was first reported in chronic lymphocytic leukemia, where miR-15 and miR-16 were found to be deleted or down-regulated in the vast majority of tumors ( Calin et al . 2002 ). Since then, a large

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Libero Santarpia, Milena Nicoloso, and George A Calin

cancer cell lines), miR-21 , miR-27 ( MDA-MB-231 cells), miR-29b-2 , miR-146 , miR-155 , miR-181 family, miR-373 and miR-520c (in metastatic tumors) Prostate cancers Let-7 family, miR-15a/miR-16-1 cluster, miR-101 , miR-125a

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Aparna Lakshmanan, Anna Wojcicka, Marta Kotlarek, Xiaoli Zhang, Krystian Jazdzewski, and Sissy M Jhiang

in PCCl3 rat thyroid cells treated with TGFβ, Akti-1/2, or 17-AAG compared with DMSO vehicle control Rat miRs TGFβ/DMSO Akti-1/2/DMSO 17-AAG/DMSO rno-miR-3578 −1.6 −2.1 −1.2 rno-miR-465 −1.6 −1.9 1.0 rno-miR-3571 1.1 −2.2 −1.4 rno-miR-344a-3p 1.1 −1

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Andrea Vecchione and Carlo M Croce

Caspase-3 miR-15a 13q14 Regulates pancreatic regeneration BCL-2 miR-16-1 13q14 Negatively regulates cell cycle progression and cell growth BCL-2 Regulates pancreatic regeneration miR-21 17q23 Unknown PTEN TMP1 PDCD

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Zsófia Tömböl, Peter M Szabó, Viktor Molnár, Zoltán Wiener, Gergely Tölgyesi, János Horányi, Peter Riesz, Peter Reismann, Attila Patócs, István Likó, Rolf-Christian Gaillard, András Falus, Károly Rácz, and Peter Igaz

frozen in liquid nitrogen after removal and stored at −80 °C until RNA isolation. miR expression profiling and quantitative reverse transcription-PCR Simultaneous miR and mRNA profiling was performed in 16 samples (four from each group). miRs showing

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Helen C Miller, Adam E Frampton, Anna Malczewska, Silvia Ottaviani, Euan A Stronach, Rashpal Flora, Daniel Kaemmerer, Gert Schwach, Roswitha Pfragner, Omar Faiz, Beata Kos-Kudła, George B Hanna, Justin Stebbing, Leandro Castellano, and Andrea Frilling

,d 2.0 0.011434466 miR-98 c,d 2.4 2.88E-15 miR-582-5p 2.0 0.003108321 let-7i-5p c,d 2.3 9.27E-16 miR-660-5p c,d 2.0 0.005523635 miR-148b-3p c,d 2.3 1.74E-22 let-7f-5p 2.0 0.011434466 miR-29b-3p 2

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Valeria Coppola, Ruggero De Maria, and Désirée Bonci

↑ ↓ ↓ miR-125b ↓ ↓ ↓ ↑ miR-128 ↓ ↓ miR-141 ↑ ↑ miR-143 ↓ ↓ miR-145 ↓ ↓ miR-146 ↑ ↓ miR-148 ↑ ↓ miR-16 ↑ ↓ ↓ ↓ miR-181