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Elina Ritvonen Division of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Eliisa Löyttyniemi Department of Biostatistics, University of Turku, Turku, Finland

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Pia Jaatinen School of Medicine, University of Tampere, Tampere, Finland
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Department of Internal Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland

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Tapani Ebeling University of Oulu, Oulu, Finland
Oulu University Hospital, Oulu, Finland

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Leena Moilanen University of Eastern Finland, Kuopio, Finland
Kuopio University Hospital, Kuopio, Finland

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Pirjo Nuutila Turku PET centre, University of Turku, Turku, Finland
Department of Endocrinology, Turku University Hospital, Turku, Finland

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Ritva Kauppinen-Mäkelin Center of Internal Medicine and Rehabilitation, Jorvi Hospital, Helsinki University Hospital, Helsinki, Finland

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Camilla Schalin-Jäntti Division of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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neoplasms ( Colao et al . 2004 , Melmed 2006 , Dekkers et al . 2008 ). In studies published before 1995, acromegaly was reported to associate with two- to three-fold increases in mortality rates compared with the general population ( Wright et al

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Zixia Tao Department of General Surgery, Thyroid and Parathyroid Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xianzhao Deng Department of General Surgery, Thyroid and Parathyroid Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Bomin Guo Department of General Surgery, Thyroid and Parathyroid Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zheng Ding Department of General Surgery, Thyroid and Parathyroid Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Youben Fan Department of General Surgery, Thyroid and Parathyroid Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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mortality, due to its high degree of malignancy ( Lim et al. 2017 ). Over the past few decades, the incidence of thyroid cancer in the USA has increased significantly ( Lim et al. 2017 , Megwalu & Moon 2022 ). This may be due to the growth in the

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Olga Husson Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands
Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Harm R Haak Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Liza N van Steenbergen Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Willy-Anne Nieuwlaat Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Boukje A C van Dijk Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Grard A P Nieuwenhuijzen Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Henrike Karim-Kos Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Johannes L Kuijpens Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Lonneke V van de Poll-Franse Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands
Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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Jan Willem W Coebergh Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands
Department of Medical Psychology and Neuropsychology, Comprehensive Cancer Centre South (CCCS), Maxima Medisch Centrum Eindhoven, Department of Endocrinology, Department of Registry and Research, Department of Surgery, Department of Public Health, VGZ Health Insurance Company, Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands

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incidence, mortality from TC remained stable in North America ( Davies & Welch 2006 ) and decreased (−23 and −28%, for men and women respectively) in the European Union ( Pacini et al . 2010 ) and prognosis is good (except for the anaplastic type of tumour

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Tae Hyuk Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Young-Eun Kim Green Cross Genome, Yongin, Korea

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Soomin Ahn Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Ji-Youn Kim Center for Clinical Medicine, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea

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Chang-Seok Ki Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Young Lyun Oh Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Kyunga Kim Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Won Yun Samsung Genome Institute, Samsung Medical Center, Seoul, Korea
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea

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Woong-Yang Park Samsung Genome Institute, Samsung Medical Center, Seoul, Korea
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung-Han Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sun Wook Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Hoon Chung Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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is important to distinguish patients who need aggressive treatment to reduce mortality from those who do not. Several clinicopathological prognostic variables have been used to stratify cancer patients, including increased age, histological type

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Marta García-Goñi Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain

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Beatriz Vázquez Gutiérrez Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain

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Miguel F Sanmamed Department of Oncology, University of Navarra, Pamplona, Spain

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Salvador Martín-Algarra Department of Oncology, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la Salud de Navarra), Pamplona, Spain

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José Luis Pérez-Gracia Department of Oncology, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la Salud de Navarra), Pamplona, Spain

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María Olmedo Department of Oncology, University of Navarra, Pamplona, Spain

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Estefanía Chumbiauca Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain

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Nerea Martín-Calvo IdiSNA (Instituto de investigación en la Salud de Navarra), Pamplona, Spain
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
CIBER de Fisiopatología de la Obesidad y la Nutrición, Pamplona, Spain

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Juan C Galofré Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

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+ patients). Of the 10 patients who had at least one positive antibody determination, eight had hypothyroidism and two had thyrotoxicosis. There were no significant differences in terms of progression or mortality among those patients with positive antibodies

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Eilon Krashin Translational Oncology Laboratory, Meir Medical Center, Kfar-Saba, Israel
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Barbara Silverman Israel National Cancer Registry, Ministry of Health, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel
School of Public Health, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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David M Steinberg Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel

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Daniel Yekutieli Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel

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Shmuel Giveon Clalit Health Services, Tel Aviv, Israel

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Offer Fabian Translational Oncology Laboratory, Meir Medical Center, Kfar-Saba, Israel

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Aleck Hercbergs Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio, USA

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Paul J Davis Department of Medicine, Albany Medical College, Albany, New York, USA

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Martin Ellis Translational Oncology Laboratory, Meir Medical Center, Kfar-Saba, Israel
Hematology Institute and Blood Bank, Meir Medical Center, Kfar-Saba, Israel
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Osnat Ashur-Fabian Translational Oncology Laboratory, Meir Medical Center, Kfar-Saba, Israel
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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history of hyperthyroidism ( Goldman et al. 1990 , Brandt et al. 2013 ) as well as subclinical hypothyroidism ( Tseng et al. 2015 ) were associated with increased overall cancer mortality. Regarding specific tumor types, few studies have assessed

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Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Brian Herron Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Stephen Cooke Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Jayna Elizabeth Smyth Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Karen R Mullan Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Estelle G Healy Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Jane Evanson Department of Radiology, Barts Health NHS Trust, London, UK

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Stephanie G Craig Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK

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Jacqueline A James Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK
Northern Ireland Biobank, Belfast Health and Social Care Trust, Belfast, UK

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Márta Korbonits Department of Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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-associated hypercortisolaemia results in considerable comorbidity and mortality ( Valassi et al. 2011 , Limumpornpetch et al. 2022 ). Comorbidities include hypertension, type 2 diabetes mellitus, cardiovascular disease, cerebrovascular disease and opportunistic infections

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Vasily N Aushev Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Kalpana Gopalakrishnan Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Susan L Teitelbaum Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Humberto Parada Jr Division of Epidemiology & Biostatistics, School of Public Health, San Diego State University, San Diego, California, USA

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Regina M Santella Department of Environmental Health Sciences, Columbia University, New York, New York, USA

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Marilie D Gammon University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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Jia Chen Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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did not find significant correlations between urinary levels of MPB and breast cancer incidence or mortality ( Parada et al. 2019 ). In our previous studies of a rat model, we found that low-dose exposure to MPB and DEP at critical windows of

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Cheng-Chieh Lin School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Chia-Ing Li School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Chiu-Shong Liu School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Wen-Yuan Lin School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Ching-Chu Chen School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Sing-Yu Yang School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Cheng-Chun Lee School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Tsai-Chung Li School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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been explored to explain the increasing mortality and morbidity of diabetes. Two studies by the same investigators examined the relationship of a 3-year variation in fasting plasma glucose (FPG), measured by coefficient of variation (CV), to cancer

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H J L M Timmers Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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F M Brouwers Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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A R M M Hermus Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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F C G J Sweep Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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A A J Verhofstad Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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A L M Verbeek Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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K Pacak Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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J W M Lenders Endocrinology (741), Pathology, Biostatistics, Department of Reproductive and Adult Endocrinology Program, Departments of

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surgery ( n =3)  Post-surgical mortality <4 weeks ( n =2, both non-metastatic)  Post-surgical follow-up of patients with apparently benign PHEO ( n =64)   Lost to follow-up ( n =3)   Benign recurrence ( n =2)   Metastases, died ( n =7)   Died, recurrence

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