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Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK
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. 2017 ). Membranes were probed with the primary antibodies rabbit anti-menin, rabbit-anti mortality factor 4-like 2 (MORF4L2), rabbit-anti GAPDH or rabbit-anti calnexin (all Abcam) and anti-rabbit horseradish peroxidase (HRP)-conjugated secondary
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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). CSCs are molecularly characterized based on the expression of cell surface receptors including integrin α6 (CD49f), integrin β1 (CD29), hylauronan receptor (CD44), and the stem cell self-renewal transcription factors NANOG , OCT4 , and SOX2 . NANOG
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
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% confidence interval 1.86–4.17). For cancer mortality, the HRs were 5.32 (2.52–11.21), whereas the HRs for cancer incidence or mortality were 2.61 (1.78–3.82). Table 3 The hazard ratios (HRs) of cancer incidence or mortality according to tertiles of time
Peptide Hormones Supraregional Assay Service (SAS), Faculty of Health and Medical Sciences, Clinical Biochemistry Department, Royal Surrey County Hospital NHS Trust, Guildford, Surrey GU2 7XX, UK
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. Molecular Endocrinology 10 286 – 297 . ( doi:10.1210/me.10.3.286 ). Elmlinger MW Sanatani MS Bell M Dannecker GE Ranke MB 1998 Elevated insulin-like growth factor (IGF) binding protein (IGFBP)-2 and IGFBP-4 expression of leukaemic T cells
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.02 (20.2–4.50) <0.001 Sensitive 30 168 1.00 56 56 1 Data were analyzed by Cox proportional hazard regression model. IGF1, insulin-like growth factor 1; IGFBP2, IGF-binding protein 2. Figure 1 (A) Overall survival (OS) and (B) progression-free survival
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IGF1R/IR HRs. Insulin-like growth factor binding proteins (IGFBPs) and type 2 insulin-like growth factor receptor (IGF2R) bind to and prevent IGF1 or IGF2 from activating receptor signaling cascade. IGF1R/IR signaling is mediated intracellulary by
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Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA
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40 to 54 . Annals of Epidemiology 4 205 – 213 . McGreevy K Hoel B Lipsitz S Hoel D 2007 Impact of nutreints on insulin-like growth factor-I, insulin-like growth factor binding protein-3, and their ratio in
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Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon
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molecules like c-Jun NH (2)-terminal kinase (JNK) and nuclear factor κB inhibitor kinase (IKK-β), indicate that the induction of stress kinase inhibitors such as heat-shock proteins (Hsp) 72 and Hsp27 improves insulin signaling via inhibition of stress
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influence some of these factors and may affect the risk of cancer and cancer-related mortality. In this review, we present epidemiological evidence of the relationship between obesity, T2D, and cancer. We also review the available literature regarding the
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cancer and nutrition. Nature Reviews. Cancer 4 206 –215. Chan JM , Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH & Pollak M 1998 Plasma insulin-like growth factor-I and prostate cancer risk: a