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Kreepa G Kooblall OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Victoria J Stokes OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Omair A Shariq OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Katherine A English OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Mark Stevenson OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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John Broxholme Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Benjamin Wright Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Helen E Lockstone Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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David Buck Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Endocrinology & Metabolism Department, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Israel

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Christopher J Yates OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Rajesh V Thakker OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK

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Kate E Lines OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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. 2017 ). Membranes were probed with the primary antibodies rabbit anti-menin, rabbit-anti mortality factor 4-like 2 (MORF4L2), rabbit-anti GAPDH or rabbit-anti calnexin (all Abcam) and anti-rabbit horseradish peroxidase (HRP)-conjugated secondary

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Qiao Zheng Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Lauren Banaszak Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Sarah Fracci Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Diana Basali Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Sarah M Dunlap Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Stephen D Hursting Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Jeremy N Rich Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Anita B Hjlemeland Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Amit Vasanji Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Nathan A Berger Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Justin D Lathia Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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Ofer Reizes Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA

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). CSCs are molecularly characterized based on the expression of cell surface receptors including integrin α6 (CD49f), integrin β1 (CD29), hylauronan receptor (CD44), and the stem cell self-renewal transcription factors NANOG , OCT4 , and SOX2 . NANOG

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Cheng-Chieh Lin School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Chia-Ing Li School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Chiu-Shong Liu School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Wen-Yuan Lin School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Ching-Chu Chen School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Sing-Yu Yang School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Cheng-Chun Lee School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Tsai-Chung Li School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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% confidence interval 1.86–4.17). For cancer mortality, the HRs were 5.32 (2.52–11.21), whereas the HRs for cancer incidence or mortality were 2.61 (1.78–3.82). Table 3 The hazard ratios (HRs) of cancer incidence or mortality according to tertiles of time

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Callum Livingstone Peptide Hormones Supraregional Assay Service (SAS), Faculty of Health and Medical Sciences, Clinical Biochemistry Department, Royal Surrey County Hospital NHS Trust, Guildford, Surrey GU2 7XX, UK
Peptide Hormones Supraregional Assay Service (SAS), Faculty of Health and Medical Sciences, Clinical Biochemistry Department, Royal Surrey County Hospital NHS Trust, Guildford, Surrey GU2 7XX, UK

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. Molecular Endocrinology 10 286 – 297 . ( doi:10.1210/me.10.3.286 ). Elmlinger MW Sanatani MS Bell M Dannecker GE Ranke MB 1998 Elevated insulin-like growth factor (IGF) binding protein (IGFBP)-2 and IGFBP-4 expression of leukaemic T cells

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Yu-Fang Huang Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

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Wen-Fang Cheng Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

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Yu-Peng Wu Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

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Ya-Min Cheng Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

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Keng-Fu Hsu Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

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Cheng-Yang Chou Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

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.02 (20.2–4.50) <0.001  Sensitive 30 168 1.00 56 56 1 Data were analyzed by Cox proportional hazard regression model. IGF1, insulin-like growth factor 1; IGFBP2, IGF-binding protein 2. Figure 1 (A) Overall survival (OS) and (B) progression-free survival

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W Solarek Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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A M Czarnecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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B Escudier Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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Z F Bielecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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F Lian Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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C Szczylik Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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IGF1R/IR HRs. Insulin-like growth factor binding proteins (IGFBPs) and type 2 insulin-like growth factor receptor (IGF2R) bind to and prevent IGF1 or IGF2 from activating receptor signaling cascade. IGF1R/IR signaling is mediated intracellulary by

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Jay H Fowke Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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Charles E Matthews Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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Herbert Yu Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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Qiuyin Cai Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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Sarah Cohen Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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Maciej S Buchowski Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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Wei Zheng Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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William J Blot Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA
Vanderbilt Epidemiology Center, Yale University, International Epidemiology Institute, Division of Gastroenterology, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA

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40 to 54 . Annals of Epidemiology 4 205 – 213 . McGreevy K Hoel B Lipsitz S Hoel D 2007 Impact of nutreints on insulin-like growth factor-I, insulin-like growth factor binding protein-3, and their ratio in

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Sefirin Djiogue Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Armel Hervé Nwabo Kamdje Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon
Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Lorella Vecchio Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Maulilio John Kipanyula Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Mohammed Farahna Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Yousef Aldebasi Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Paul Faustin Seke Etet Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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molecules like c-Jun NH (2)-terminal kinase (JNK) and nuclear factor κB inhibitor kinase (IKK-β), indicate that the induction of stress kinase inhibitors such as heat-shock proteins (Hsp) 72 and Hsp27 improves insulin signaling via inhibition of stress

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Dara Hope Cohen Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

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Derek LeRoith Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

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influence some of these factors and may affect the risk of cancer and cancer-related mortality. In this review, we present epidemiological evidence of the relationship between obesity, T2D, and cancer. We also review the available literature regarding the

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cancer and nutrition. Nature Reviews. Cancer 4 206 –215. Chan JM , Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH & Pollak M 1998 Plasma insulin-like growth factor-I and prostate cancer risk: a

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