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Claudio Ricci Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Stefano Partelli Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Carlo Ingaldi Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Valentina Andreasi Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Davide Campana Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Francesca Muffatti Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Laura Alberici Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Cecilia Giorgi Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Riccardo Casadei Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Massimo Falconi Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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resulting long overall survival (OS), even in the presence of recurrent disease, makes it difficult to design multi-arm randomized trials due to the long observation period needed. Some authors advocate ( Kulke et al. 2011 ) the use of progression

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Seyedhossein Aharinejad Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Mohamed Salama Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Patrick Paulus Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Karin Zins Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Andreas Berger Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Christian F Singer Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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women who had developed breast cancer during 1992 and 1998, and the results were published in 2008. We prospectively evaluated serum CSF1 concentrations, clinical, and histo-pathological parameters and 5-year overall survival (OS) in 1260 women with

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Klaas Van Den Heede Department of Surgery, Skåne University Hospital, Lund, Sweden
Department of Clinical Sciences, Lund University, Lund, Sweden
Department of General and Endocrine Surgery, OLV Clinic Aalst, Aalst, Belgium

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Swathikan Chidambaram Department of Surgery and Cancer, Imperial College London, London, UK
Department of Endocrine Surgery, Hammersmith Hospital, London, UK

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Sam Van Slycke Department of General and Endocrine Surgery, OLV Clinic Aalst, Aalst, Belgium
Department of Head and Skin, University Hospital Ghent, Ghent, Belgium
Department of General Surgery, AZ Damiaan, Ostend, Belgium

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Nele Brusselaers Center for Translational Microbiome Research Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Global Health Institute, University of Antwerp, Wilrijk, Belgium

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Carl Fredrik Warfvinge Department of Clinical Sciences, Lund University, Lund, Sweden
Department of Oncology and Pathology, Lund University, Lund, Sweden

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Håkan Ohlsson Department of Clinical Sciences, Lund University, Lund, Sweden
Department of Surgery, Ystad Hospital, Ystad, Sweden

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Rita Gustafsson Department of Gastroenterology and Hepatology, Lund University, Lund, Sweden

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Erik Nordenström Department of Surgery, Skåne University Hospital, Lund, Sweden
Department of Clinical Sciences, Lund University, Lund, Sweden

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Martin Almquist Department of Surgery, Skåne University Hospital, Lund, Sweden
Department of Clinical Sciences, Lund University, Lund, Sweden

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siNETs and improved treatment options seem to result in a favorable overall survival, even in an advanced, metastatic setting at diagnosis ( Yao et al. 2008 , Rinke et al. 2009 , Wyld et al. 2021 ). Differences in terminology (historical), lack of

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T P Links
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K M van Tol
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P L Jager
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J Th M Plukker
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D A Piers
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H M Boezen
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R P F Dullaart
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E G E de Vries
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W J Sluiter
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specific and overall, decrease with advancing age at diagnosis and should be reported separately for several age categories within the sample. By analogy, visual presentation as, for example, by Kaplan–Meier plots should include survival curves for each age

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Anela Blažević Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Wouter T Zandee Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Gaston J H Franssen Department of Surgery, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Johannes Hofland Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Marie-Louise F van Velthuysen Department of Pathology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Leo J Hofland Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Richard A Feelders Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Wouter W de Herder Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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(data not shown). Effect of mesenteric fibrosis on survival During a median follow-up time of 62.3 months (IQR 32.9–103.4), 208 patients died. Kaplan–Meier analysis demonstrated that patients with MF had a significantly shorter overall survival

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Yu-Li Chen College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Cheng-Yang Chou College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Ming-Cheng Chang College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Han-Wei Lin College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Ching-Ting Huang College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Shu-Feng Hsieh College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Chi-An Chen College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Wen-Fang Cheng College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan

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Introduction Ovarian carcinoma is the most lethal gynecologic malignancy ( Jemal et al . 2011 ). The standard treatment for this disease is debulking surgery followed by platinum-based chemotherapy; however, the overall survival (OS) rate is around

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Carmine Valenza Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy

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Francesca Spada Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Francesco Multinu Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Lavinia Benini Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Michele Borghesani Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Laura Algeri Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Manila Rubino Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Eleonora Pisa Division of Pathology and Laboratory Medicine, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Lorenzo Gervaso Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Chiara Alessandra Cella Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Silvestro Carinelli Division of Pathology and Laboratory Medicine, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Simone Bruni Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Gabriella Schivardi Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Giuseppe Curigliano Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy

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Vanna Zanagnolo Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Giovanni Aletti Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy
Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Nicoletta Colombo Division of Gynecologic Oncology, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

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Nicola Fazio Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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, respectively ( Gadducci et al. 2017 ). The prognosis is extremely poor and depends on the disease extension: 5-year overall survival (OS) rate ranges from 30 to 60% in patients with early stage disease to 0–15% in those with metastatic disease ( Tempfer et

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Thierry Petit
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Patrick Dufour
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Ian Tannock Department of Medical Oncology, Division of Medical Oncology and Haematology, Paul Strauss Cancer Center, and University of Strasbourg, 3 rue de la Porte de l'Hôpital - BP42, F-67065 Strasbourg, France

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with metastatic breast cancer. These drugs increase the rate of tumour response and enhance progression-free survival from 6 to 10 months, but none of the randomised studies has shown an improvement in overall survival ( Bonneterre et al . 2001

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Zaid Al-Qurayshi Department of Otolaryngology – Head & Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA

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Mohamed A Shama Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA
Department of Head and Neck Surgical Oncology, NCI, Cairo University, Cairo, Egypt

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Gregory W Randolph Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

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Emad Kandil Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA

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://www.facs.org/quality-programs/cancer/ncdb ) Accessed October 15, 2015). The primary study objective is to assess the impact of tumor size and MEE on the overall survival in patients with DTC. The secondary study objective is to assess the survival benefit of total thyroidectomy vs lobectomy and

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Sten Myrehaug Department of Radiation Oncology, University of Toronto

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David L Chan Department of Medical Oncology, University of Sydney, Royal North Shore Hospital, Sydney, Australia

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Victor Rodriguez-Freixinos Division of Medical Oncology, University of Toronto, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada

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Hans Chung Department of Radiation Oncology, University of Toronto

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Julie Hallet Department of Surgery, University of Toronto, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada

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Calvin Law Department of Surgery, University of Toronto, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada

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Chirag Patel Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Canada

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Laurent Milot Body and VIR Department, University Hospital Edouard Herriot, Lyon, France

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John Hudson Department of Radiation Oncology, University of Toronto

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Hanbo Chen Department of Radiation Oncology, University of Toronto

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Simron Singh Division of Medical Oncology, University of Toronto, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada

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rate of combined everolimus and radiation as measured by RECIST v1.1, per-lesion local control, progression-free survival and overall survival. Patients were clinically assessed following 14 and 28 days of initial everolimus, weekly during concurrent

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