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different degrees of malignancy from benign adenomas, which are not invasive and very well differentiated, to the undifferentiated anaplastic thyroid carcinomas, which are very aggressive and always fatal. Papillary and follicular carcinomas, the most common

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Alfred King-yin Lam Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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Nassim Saremi Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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Introduction Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is an uncommon variant of papillary thyroid carcinoma. It is a variant of papillary thyroid carcinoma recognized in the current World Health Organization (WHO

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Henry Crayton Department of Endocrine Surgery, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia
Northern Clinical School, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia

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Katherine Wu Department of Endocrinology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia

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David Leong Department of Endocrine Surgery, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia

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Nazim Bhimani The Kinghorn Cancer Centre, Garvan Institute of Medical Research, St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia

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Matti Gild Northern Clinical School, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
Department of Endocrinology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia

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Anthony Glover Department of Endocrine Surgery, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia
Northern Clinical School, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia

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Introduction Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer, comprising 80% of all thyroid cancers ( Hundahl et al. 2000 ). The diffuse sclerosing variant (DSV) of PTC is a rare variant, comprising 0.7–5.3% of

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Kensey Bergdorf Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Donna C Ferguson Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Mitra Mehrad Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Kim Ely Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Thomas Stricker Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Vivian L Weiss Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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analysis. In this Institutional Review Board approved study, files from 2008 to 2017 containing diagnoses of classical papillary thyroid carcinoma (PTC, N  = 20), follicular variant of PTC (FVTPC, N  = 12) and non-invasive follicular thyroid neoplasm with

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Luca Morandi Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology ‘M. Malpighi’ at Bellaria Hospital, University of Bologna, Bologna, Italy

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Alberto Righi Department of Pathology, Rizzoli Institute, (IRCCS), Bologna, Italy

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Francesca Maletta Department of Medical Sciences, University of Turin, Turin, Italy

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Paola Rucci Section of Hygiene and Biostatistics, University of Bologna, Bologna, Italy

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Fabio Pagni Department of Pathology, University of Milano Bicocca, Monza, Italy

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Marco Gallo Oncological Endocrinology Unit, Department of Medical Sciences, AOU Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy

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Sabrina Rossi Department of Pathology, Regional Hospital, Treviso, Italy

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Leonardo Caporali Istituto delle Scienze Neurologiche di Bologna (IRCCS), Bellaria Hospital, Bologna, Italy

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Anna Sapino Institute for Cancer Research and Treatment (IRCCS), Candiolo, Italy

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Ricardo V Lloyd University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

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Sofia Asioli Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology ‘M. Malpighi’ at Bellaria Hospital, University of Bologna, Bologna, Italy

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Introduction Thyroid cancer is the most common type of endocrine malignancy. The vast majority of thyroid tumors originate from thyroid follicular cells and encompasses well-differentiated papillary carcinoma and follicular carcinoma. Its

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Rodolfo Iuliano
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Dario Palmieri Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy
Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Huiling He Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Angela Iervolino Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy
Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Eleonora Borbone Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy
Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Pierlorenzo Pallante Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy
Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Alessandra Cianflone Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Rebecca Nagy Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Hansjuerg Alder Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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George A Calin Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Francesco Trapasso
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Carla Giordano Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Carlo M Croce Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Albert de la Chapelle Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Alfredo Fusco Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy
Dipartimento di Medicina Sperimentale e Clinica, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o, NOGEC (Naples Oncogenomic Center) – CEINGE, Division of Human Cancer Genetics, Sezione di Endocrinologia, Facoltà di Medicina e Chirurgia, Università degli Studi ‘Magna Græcia’ di Catanzaro, Campus ‘Salvatore Venuta’ Viale Europa, località Germaneto, 88100 Catanzaro, Italy

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Introduction Papillary thyroid carcinoma (PTC), a differentiated tumor arising from the follicular cells of thyroid, is the most frequent type of thyroid cancer. Although a major risk factor for PTC is the exposure to ionizing radiations ( Nagataki

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Adam Stenman Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Samuel Backman Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Klara Johansson Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Johan O Paulsson Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Peter Stålberg Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden

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-cell derived neoplasia denoted as pediatric papillary thyroid carcinoma (pPTC) or pediatric follicular thyroid carcinoma, while small subsets of cases are derived from the parafollicular C-cells; namely pediatric medullary thyroid carcinoma. As in adult

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Seog Yun Park Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Yuh-S Jung Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Chang Hwan Ryu Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Chang Yoon Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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You Jin Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Eun Kyung Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Seok-Ki Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Tae Sung Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Tae Hyun Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jeyun Jang Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Daeyoon Park Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Seung Myung Dong Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jae-Goo Kang Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jin Soo Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Junsun Ryu Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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). Papillary thyroid carcinoma (PTC) comprises ∼90% of all thyroid malignancies and has an excellent prognosis with conventional therapies such as surgery and radioactive iodine therapy. Despite advances in the understanding of the underlying biological

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Eric Y Lian Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada
Department of Pathology & Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Sarah M Maritan Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada
Department of Pathology & Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Jessica G Cockburn Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada
Department of Pathology & Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Katayoon Kasaian Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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Mathieu J F Crupi Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada
Department of Pathology & Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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David Hurlbut Department of Pathology & Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Steven J M Jones Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
Department of Medical Genetics, University of British Columbia, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

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Sam M Wiseman Department of Surgery, St Paul’s Hospital & University of British Columbia, Vancouver, British Columbia, Canada

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Lois M Mulligan Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada
Department of Pathology & Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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in sporadic forms of MTC ( Mulligan 2014 ). In contrast, in the follicular cell tumour papillary thyroid carcinoma (PTC), rearrangements of the RET gene result in a constitutively active RET kinase fusion protein (RET/PTC) localised in the cytosol

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Seo Ki Kim Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jung-Woo Woo Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jun Ho Lee Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Inhye Park Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jung-Han Kim Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Introduction With a rapidly increasing incidence worldwide, papillary thyroid carcinoma (PTC) represents the majority of thyroid cancer cases ( Ahn & Park 2009 , Siegel et al . 2014 ). The recently discovered BRAF V600E mutation (hereafter

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