different degrees of malignancy from benign adenomas, which are not invasive and very well differentiated, to the undifferentiated anaplastic thyroid carcinomas, which are very aggressive and always fatal. Papillary and follicular carcinomas, the most common
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P Pallante, R Visone, M Ferracin, A Ferraro, M T Berlingieri, G Troncone, G Chiappetta, C G Liu, M Santoro, M Negrini, C M Croce, and A Fusco
Alfred King-yin Lam and Nassim Saremi
Introduction Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is an uncommon variant of papillary thyroid carcinoma. It is a variant of papillary thyroid carcinoma recognized in the current World Health Organization (WHO
Kensey Bergdorf, Donna C Ferguson, Mitra Mehrad, Kim Ely, Thomas Stricker, and Vivian L Weiss
analysis. In this Institutional Review Board approved study, files from 2008 to 2017 containing diagnoses of classical papillary thyroid carcinoma (PTC, N = 20), follicular variant of PTC (FVTPC, N = 12) and non-invasive follicular thyroid neoplasm with
Luca Morandi, Alberto Righi, Francesca Maletta, Paola Rucci, Fabio Pagni, Marco Gallo, Sabrina Rossi, Leonardo Caporali, Anna Sapino, Ricardo V Lloyd, and Sofia Asioli
Introduction Thyroid cancer is the most common type of endocrine malignancy. The vast majority of thyroid tumors originate from thyroid follicular cells and encompasses well-differentiated papillary carcinoma and follicular carcinoma. Its
Rodolfo Iuliano, Dario Palmieri, Huiling He, Angela Iervolino, Eleonora Borbone, Pierlorenzo Pallante, Alessandra Cianflone, Rebecca Nagy, Hansjuerg Alder, George A Calin, Francesco Trapasso, Carla Giordano, Carlo M Croce, Albert de la Chapelle, and Alfredo Fusco
Introduction Papillary thyroid carcinoma (PTC), a differentiated tumor arising from the follicular cells of thyroid, is the most frequent type of thyroid cancer. Although a major risk factor for PTC is the exposure to ionizing radiations ( Nagataki
Adam Stenman, Samuel Backman, Klara Johansson, Johan O Paulsson, Peter Stålberg, Jan Zedenius, and C Christofer Juhlin
-cell derived neoplasia denoted as pediatric papillary thyroid carcinoma (pPTC) or pediatric follicular thyroid carcinoma, while small subsets of cases are derived from the parafollicular C-cells; namely pediatric medullary thyroid carcinoma. As in adult
Seog Yun Park, Yuh-S Jung, Chang Hwan Ryu, Chang Yoon Lee, You Jin Lee, Eun Kyung Lee, Seok-Ki Kim, Tae Sung Kim, Tae Hyun Kim, Jeyun Jang, Daeyoon Park, Seung Myung Dong, Jae-Goo Kang, Jin Soo Lee, and Junsun Ryu
). Papillary thyroid carcinoma (PTC) comprises ∼90% of all thyroid malignancies and has an excellent prognosis with conventional therapies such as surgery and radioactive iodine therapy. Despite advances in the understanding of the underlying biological
Eric Y Lian, Sarah M Maritan, Jessica G Cockburn, Katayoon Kasaian, Mathieu J F Crupi, David Hurlbut, Steven J M Jones, Sam M Wiseman, and Lois M Mulligan
in sporadic forms of MTC ( Mulligan 2014 ). In contrast, in the follicular cell tumour papillary thyroid carcinoma (PTC), rearrangements of the RET gene result in a constitutively active RET kinase fusion protein (RET/PTC) localised in the cytosol
Seo Ki Kim, Jung-Woo Woo, Jun Ho Lee, Inhye Park, Jun-Ho Choe, Jung-Han Kim, and Jee Soo Kim
Introduction With a rapidly increasing incidence worldwide, papillary thyroid carcinoma (PTC) represents the majority of thyroid cancer cases ( Ahn & Park 2009 , Siegel et al . 2014 ). The recently discovered BRAF V600E mutation (hereafter
Raffaele Ciampi, Thomas J Giordano, Kathryn Wikenheiser-Brokamp, Ronald J Koenig, and Yuri E Nikiforov
Introduction Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and accounts for ~80% of all thyroid malignancies ( Hundahl et al. 2000 ). Genetic alterations along the RET/RAS/BRAF/ MAPK signaling