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Samuel M O’Toole, David S Watson, Tatiana V Novoselova, Lisa E L Romano, Peter J King, Teisha Y Bradshaw, Clare L Thompson, Martin M Knight, Tyson V Sharp, Michael R Barnes, Umasuthan Srirangalingam, William M Drake and J Paul Chapple

Introduction Pheochromocytomas (PCCs) are neuroendocrine tumors that originate from chromaffin cells of the adrenal medulla or autonomic nervous system, where they are termed paragangliomas (PGLs). The majority of the morbidity associated with

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Birke Bausch, Ulrich Wellner, Dirk Bausch, Francesca Schiavi, Marta Barontini, Gabriela Sanso, Martin K Walz, Mariola Peczkowska, Georges Weryha, Patrizia Dall'Igna, Giovanni Cecchetto, Gianni Bisogno, Lars C Moeller, Detlef Bockenhauer, Attila Patocs, Karoly Rácz, Dmitry Zabolotnyi, Svetlana Yaremchuk, Iveta Dzivite-Krisane, Frederic Castinetti, David Taieb, Angelica Malinoc, Ernst von Dobschuetz, Jochen Roessler, Kurt W Schmid, Giuseppe Opocher, Charis Eng and Hartmut P H Neumann

Introduction Pheochromocytomas and paragangliomas are tumors of the overall paraganglial system, mainly the adrenal glands, the retroperitoneum, the pelvis, the thorax, and the skullbase and neck regions ( Neumann 2008 ). Such paraganglial tumors

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Trisha Dwight, Aidan Flynn, Kaushalya Amarasinghe, Diana E Benn, Richard Lupat, Jason Li, Daniel L Cameron, Annette Hogg, Shiva Balachander, Ida L M Candiloro, Stephen Q Wong, Bruce G Robinson, Anthony T Papenfuss, Anthony J Gill, Alexander Dobrovic, Rodney J Hicks, Roderick J Clifton-Bligh and Richard W Tothill

Introduction Pheochromocytomas (PC) and paragangliomas (PGLs) are neuroendocrine tumors derived from neural crest cells of the sympathetic and parasympathetic nervous system – PCs arising in the adrenal medulla and PGLs in paraganglia outside

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Pauline Croisé, Sébastien Houy, Mathieu Gand, Joël Lanoix, Valérie Calco, Petra Tóth, Laurent Brunaud, Sandra Lomazzi, Eustache Paramithiotis, Daniel Chelsky, Stéphane Ory and Stéphane Gasman

. Results Protein expression and activity of RhoA, Rac1 and Cdc42 in human pheochromocytomas The expression level and the activity of Rho GTPases have never been explored in human PCC. To do so, we have used the ELISA-based assay (G-LISA; Cytoskeleton

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Aguirre A de Cubas, L Javier Leandro-García, Francesca Schiavi, Veronika Mancikova, Iñaki Comino-Méndez, Lucía Inglada-Pérez, Manuel Perez-Martinez, Nuria Ibarz, Pilar Ximénez-Embún, Elena López-Jiménez, Agnieszka Maliszewska, Rocío Letón, Álvaro Gómez Graña, Carmen Bernal, Cristina Álvarez-Escolá, Cristina Rodríguez-Antona, Giuseppe Opocher, Javier Muñoz, Diego Megias, Alberto Cascón and Mercedes Robledo

Introduction Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors of neural crest origin. Up to an estimated 60% of PCCs/PGLs are associated with germline or somatic mutations in one many susceptibility genes ( RET

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Joakim Crona, Angela Lamarca, Suman Ghosal, Staffan Welin, Britt Skogseid and Karel Pacak

Introduction The Cancer Genome Atlas (TCGA) proposed that neuroendocrine tumors of adrenal paraganglia, pheochromocytomas (PCCs) and extra-adrenal paraganglia paragangliomas (PGLs, together denoted PPGL) can be divided into three main

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Jenny Welander, Adam Andreasson, Michael Brauckhoff, Martin Bäckdahl, Catharina Larsson, Oliver Gimm and Peter Söderkvist

Introduction Pheochromocytomas and abdominal paragangliomas are catecholamine-producing tumors derived from neuroendocrine chromaffin cells in the adrenal medulla or the extra-adrenal paraganglia. The tumors can be a manifestation of different

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Woo-Jae Park, Ori Brenner, Aviram Kogot-Levin, Ann Saada, Alfred H Merrill Jr, Yael Pewzner-Jung and Anthony H Futerman

gland, and in particular with pheochromocytoma (PCC) ( Pacak 2011 ). In humans, PCC is a rare tumor of which ∼25% of cases are associated with germline mutations, commonly in subunits of succinate dehydrogenase (SDH), which is part of mitochondrial

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Carole Guerin, Pauline Romanet, David Taieb, Thierry Brue, André Lacroix, Frederic Sebag, Anne Barlier and Frederic Castinetti

development of pheochromocytoma (PHEO), and less frequently of hyperparathyroidism (HPTH). The aim of this review is first to detail the main characteristics and the management of MEN2 PHEO and then to define the main other etiologies of hereditary bilateral

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V H M Tsang, T Dwight, D E Benn, G Y Meyer-Rochow, A J Gill, M Sywak, S Sidhu, D Veivers, C M Sue, B G Robinson, R J Clifton-Bligh and N R Parker

Introduction Pheochromocytomas (PCs) are catecholamine-secreting tumours of chromaffin cells of the adrenal medulla and are closely related to paragangliomas (PGLs) which arise from sympathetic and parasympathetic chains ( Favier et al . 2005