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Introduction Pituitary tumors are invariably benign neoplasms identified in ∼25% of unselected autopsy specimens, and may cause considerable morbidity due to excess hormone secretion and/or compression of surrounding brain structures ( Melmed 2003
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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Introduction Pituitary tumors are generally benign adenomas. Radiology and autopsy, being performed for reasons other than pituitary-related medical ones, show a high prevalence of 10–15% in the overall population, although most of these lesions are
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The pituitary The anterior pituitary produces peptide hormones under the control of feedback from hormones secreted by the hypothalamus and the peripheral endocrine glands. This is enabled by five different populations of cells: corticotrophs
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Introduction Pituitary tumors are common, with increasing prevalences being reported ( Ezzat et al. 2004 , Daly et al. 2006 , Fernandez et al. 2009 , Fontana & Gaillard 2009 , Tjornstrand et al. 2014 , Agustsson et al. 2015
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Introduction The pituitary gland is a principal controller of endocrine homeostasis. Through the release of specific hormones synthesized by five highly differentiated cells, this gland responds to central and peripheral signals. In spite of
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Introduction Pituitary adenomas (PAs) arise in different adenohypophyseal cells and represent 15% of intracranial tumors ( Melmed 2011 , Osamura 2017 a ). The majority are slow-growing, noninvasive and benign neoplasms; however, several
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CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina
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Introduction Pituitary adenomas are mostly benign intracranial tumors, which do not metastasize but may recur after surgical removal, compress nearby structures or produce considerable morbidity related to hormonal dysfunction. A subset of
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Introduction Pituitary adenomas (PA) and phaeochromocytomas/paragangliomas (phaeo/PGL) are relatively rare tumours. The prevalence of symptomatic PA in the general population is around 1 in 1000 ( Daly et al . 2006 , Fernandez et al . 2010 ). The
Guys Richard Dimbleby Department of Cancer Research, Kings College London, London, UK
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Centre for Endocrinology, William Harvey Institute, Barts and the London School of Medicine, London, UK
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Introduction Pituitary tumours represent approximately 10–15% of intracranial tumours. Most of them are non-invasive, showing slow growth and remaining within the sella and/or displacing the surrounding tissues; however, up to 25–55% of
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Since the early work of Minkowski, who attributed acromegaly to a pituitary tumor ( Minkowski 1887 ), neoplasms composed of pituitary adenohypophysial cells have been recognized as the cause of significant illness. However, Harvey Cushing