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T J G Chambers
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A Giles
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G Brabant Endocrinology and Diabetes Group, Experimental and Clinical Endocrinology, Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK

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J R E Davis
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develop. Pituitary adenomas are surprisingly common with an estimated prevalence of 17% ( Ezzat et al . 2004 ). The proliferation of tumours differs from the physiological expansion in cell populations in that tumours are thought to be monoclonal. However

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0005
Volume/Issue:
Volume 20: Issue 3
Free access
Freya Mertens Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Lies Gremeaux Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Jianghai Chen Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Qiuli Fu Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Christophe Willems Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Heleen Roose Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Olivier Govaere Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Tania Roskams Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Carolina Cristina Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Damasia Becú-Villalobos Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Mark Jorissen Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Vincent Vander Poorten Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Marie Bex Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Johannes van Loon Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Hugo Vankelecom Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Introduction Pituitary tumors are generally benign adenomas. Radiology and autopsy, being performed for reasons other than pituitary-related medical ones, show a high prevalence of 10–15% in the overall population, although most of these lesions are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0546
Volume/Issue:
Volume 22: Issue 4
Free access
Kari Hemminki
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Asta Försti
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Jianguang Ji
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Introduction Pituitary adenomas are indolent tumors, which account for 10–15% of all diagnosed intracranial neoplasms ( Asa & Ezzat 2002 , DeLellis et al. 2004 ). Small adenomas may occur in up to 15% of pituitary glands examined

Article Type:
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DOI:
https://doi.org/10.1677/ERC-06-0008
Volume/Issue:
Volume 14: Issue 1
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Robert C Fowkes
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George Vlotides Endocrine Signalling Group, Department of Internal Medicine II, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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adenomas, as highest levels of microvessel density are detected in rare pituitary carcinomas ( Vidal et al . 2001 ). In the absence of a strong correlation between pituitary tumorigenesis in general and angiogenesis ( Vidal et al . 2000 ), the fact that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0297
Volume/Issue:
Volume 19: Issue 1
Free access
S L Asa Department of Pathology and Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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O Casar-Borota Department of Pathology, Uppsala University Hospital, Uppsala, Sweden

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P Chanson Service of Endocrinology and Reproductive Diseases, Bicêtre Hospital, Paris, France

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E Delgrange Department of Medicine, University of Louvain, Mont-sur-Meuse, Belgium

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P Earls Department of Anatomical Pathology, St Vincent’s Hospital, Sydney, Australia

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S Ezzat Department of Medicine and Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada

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A Grossman Department of Endocrinology, University of Oxford, Oxford, UK

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H Ikeda Research Institute for Pituitary Disease, Southern Tohoku General Hospital, Fukushima, Japan

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N Inoshita Department of Pathology, Toranomon Hospital, Tokyo, Japan

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N Karavitaki Department of Endocrinology, Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK

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M Korbonits Division of Endocrinology, Queen Mary Hospital, Barts and the London School of Medicine, London, UK

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E R Laws Jr Department of Neurosurgery, Harvard Medical School, Brigham & Women’s Hospital, Boston, Massachusetts, USA

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M B Lopes Departments of Pathology and Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA

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N Maartens Department of Neurosurgery, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia

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I E McCutcheon Department of Neurosurgery, UT MD Anderson Cancer Center, Houston, Texas, USA

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O Mete Department of Pathology and Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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H Nishioka Department of Neurosurgery, Toranomon Hospital, Tokyo, Japan

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G Raverot Department of Endocrinology, Groupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France

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F Roncaroli Department of Neuropathology, Imperial College, London, UK

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W Saeger Institute of Neuropathology of the University of Hamburg, Hamburg, Germany

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L V Syro Department of Neurosurgery, Hospital Pablo Tobon Uribe, Medellin, Colombia

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A Vasiljevic Department of Pathology, Groupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France

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C Villa Department of Pathology, Hôpital Foch, Suresnes, France

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A Wierinckx INSERM U1052, Cancer Research Center of Lyon, University of Lyon, Lyon, France

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J Trouillas Faculty of Medicine Lyon-Est, University of Lyon, Lyon, France

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and the attendees of 14th Meeting of the International Pituitary Pathology Club, Annecy, France, November 2016
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. Traditional classifications only recognize malignancy, denoted as pituitary carcinoma, when there is evidence of distant metastasis or cerebrospinal spread ( DeLellis et al. 2004 ). The attempt to classify a subgroup as ‘atypical adenomas’ based on the

Article Type:
Article Commentary
DOI:
https://doi.org/10.1530/ERC-17-0004
Volume/Issue:
Volume 24: Issue 4
Free access
Chiara Villa Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France
Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Maria Stefania Lagonigro Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Flavia Magri Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Maria Koziak Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Marie-Lise Jaffrain-Rea Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France
Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Raja Brauner Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Jerome Bouligand Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Marie Pierre Junier Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Federico Di Rocco Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Christian Sainte-Rose Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Albert Beckers Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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François Xavier Roux Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Adrian F Daly Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Luca Chiovato Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Introduction Pituitary adenomas are the most common tumors arising in the pituitary gland, with a prevalence of about 17% in unselected autopsy and radiological series ( Ezzat et al . 2004 ). Clinically relevant anterior pituitary tumors have

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0059
Volume/Issue:
Volume 18: Issue 3
Free access
Ines Donangelo Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Song-Guang Ren Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Tamar Eigler Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Clive Svendsen Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Shlomo Melmed Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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). However, precisely how pituitary adenomas develop and progress and the molecular bases of their unique features are poorly understood. Stem cells are unspecialized cells with the ability to self-renew (ability to go through numerous cycles of cell division

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0229
Volume/Issue:
Volume 21: Issue 2
Free access
Annamaria Colao Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Carolina Di Somma Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Rosario Pivonello Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Antongiulio Faggiano Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Gaetano Lombardi Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Silvia Savastano Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Introduction Non-functioning pituitary adenomas (NFAs) represent a very heterogeneous group of tumours, accounting for 25% of all pituitary adenomas ( Katznelson et al . 1993 ). They often present with macroadenomas that cause neurological symptoms

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0181
Volume/Issue:
Volume 15: Issue 4
Free access
Katharina Lampichler Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Patricio Ferrer Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Greisa Vila Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Mirjam I Lutz Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Florian Wolf Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Engelbert Knosp Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Ludwig Wagner Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Anton Luger Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Sabina Baumgartner-Parzer Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III

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Introduction The anterior pituitary gland is a key regulator of the endocrine system. During the life-span it undergoes extensive remodeling responding to metabolic changes and is therefore prone to tumor formation. Pituitary adenomas are the most

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0109
Volume/Issue:
Volume 22: Issue 5
Free access
K Revill
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K J Dudley
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R N Clayton
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A M McNicol Human Disease and Genomics Group, Molecular and Cellular Pathology, School of Medicine, Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, Staffordshire ST4 7QB, UK

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W E Farrell
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frequent finding in pituitary adenomas where most studies, with limited exceptions, have adopted candidate gene approaches of primary human adenomas ( Zhang et al . 2003 , Bahar et al . 2004 , Zhao et al . 2005 ). Recently, our laboratory using a whole

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0008
Volume/Issue:
Volume 16: Issue 2
Free access