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Toru Tateno, Tae Nakano-Tateno, Shereen Ezzat, and Sylvia L Asa

Introduction Pituitary tumors are common, with increasing prevalences being reported ( Ezzat et al. 2004 , Daly et al. 2006 , Fernandez et al. 2009 , Fontana & Gaillard 2009 , Tjornstrand et al. 2014 , Agustsson et al. 2015

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Ines Donangelo, Song-Guang Ren, Tamar Eigler, Clive Svendsen, and Shlomo Melmed

Introduction Pituitary tumors are invariably benign neoplasms identified in ∼25% of unselected autopsy specimens, and may cause considerable morbidity due to excess hormone secretion and/or compression of surrounding brain structures ( Melmed 2003

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Kari Hemminki, Asta Försti, and Jianguang Ji

Introduction Pituitary adenomas are indolent tumors, which account for 10–15% of all diagnosed intracranial neoplasms ( Asa & Ezzat 2002 , DeLellis et al. 2004 ). Small adenomas may occur in up to 15% of pituitary glands examined

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Mirela Diana Ilie, Alexandre Vasiljevic, Emmanuel Jouanneau, and Gérald Raverot

Introduction Anterior pituitary tumors are usually benign neoplasms that derive from the endocrine cells of the anterior pituitary gland. However, a small percentage of them have an aggressive behavior, showing resistance and/or multiple

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Charlotte Nys, Yu-Lun Lee, Heleen Roose, Freya Mertens, Ellen De Pauw, Hiroto Kobayashi, Raf Sciot, Marie Bex, Georges Versyck, Steven De Vleeschouwer, Johannes Van Loon, Emma Laporte, and Hugo Vankelecom

prevalent, being detected in 15–25% of the general population, with serious clinical symptoms in 0.1% ( Ezzat et al. 2004 , Daly et al. 2009 , Mete & Lopes 2017 , Melmed 2020 ). Although pituitary tumors mainly represent benign and slow

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Freya Mertens, Lies Gremeaux, Jianghai Chen, Qiuli Fu, Christophe Willems, Heleen Roose, Olivier Govaere, Tania Roskams, Carolina Cristina, Damasia Becú-Villalobos, Mark Jorissen, Vincent Vander Poorten, Marie Bex, Johannes van Loon, and Hugo Vankelecom

Introduction Pituitary tumors are generally benign adenomas. Radiology and autopsy, being performed for reasons other than pituitary-related medical ones, show a high prevalence of 10–15% in the overall population, although most of these lesions are

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S L Asa, O Casar-Borota, P Chanson, E Delgrange, P Earls, S Ezzat, A Grossman, H Ikeda, N Inoshita, N Karavitaki, M Korbonits, E R Laws Jr, M B Lopes, N Maartens, I E McCutcheon, O Mete, H Nishioka, G Raverot, F Roncaroli, W Saeger, L V Syro, A Vasiljevic, C Villa, A Wierinckx, J Trouillas, and and the attendees of 14th Meeting of the International Pituitary Pathology Club, Annecy, France, November 2016

Since the early work of Minkowski, who attributed acromegaly to a pituitary tumor ( Minkowski 1887 ), neoplasms composed of pituitary adenohypophysial cells have been recognized as the cause of significant illness. However, Harvey Cushing

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G Mantovani, D Treppiedi, E Giardino, R Catalano, F Mangili, P Vercesi, M Arosio, A Spada, and E Peverelli

Introduction Pituitary tumors, accounting for 16.2% of all primary brain and other central nervous system tumors ( Ostrom et al. 2017 ), are classified based on their secretory activity in non-functioning pituitary tumors (NFPTs) or hormone

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Cuiqi Zhou, Yunguang Tong, Kolja Wawrowsky, Serguei Bannykh, Ines Donangelo, and Shlomo Melmed

Introduction Pituitary tumor transforming gene (PTTG1), the index mammalian securin, was isolated from rat pituitary tumor cells ( Pei & Melmed 1997 ), and the human homolog (hPTTG1) was identified as a proto-oncogene ( Zhang et al . 1999 b

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Yong Lin, Xiaofei Jiang, Ye Shen, Min Li, Huili Ma, Mingzhao Xing, and Yuan Lu

et al . 2002 , Byun et al . 2003 , Samuels et al . 2004 , Wu et al . 2005 , Kozaki et al . 2006 ). Pituitary tumors are common endocrine neoplastic diseases. Multiple tumor-promoting factors or signaling pathways are known to be involved