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David Taïeb
David Taïeb
Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France
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Christelle Fargette
Christelle Fargette
Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France
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Abhishek Jha
Abhishek Jha
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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Karel Pacak
Karel Pacak
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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Nuclear medicine as a component of precision medicine This article is a summary of a plenary lecture presented at the 6th International Symposium on Pheochromocytoma/Paraganglioma (20 October 2022, Prague, Czech Republic), which explored the
Masaki Shiota
Masaki Shiota
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Shusuke Akamatsu
Shusuke Akamatsu
Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Shigehiro Tsukahara
Shigehiro Tsukahara
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Shohei Nagakawa
Shohei Nagakawa
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Takashi Matsumoto
Takashi Matsumoto
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Masatoshi Eto
Masatoshi Eto
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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mutations has been suggested, and information about the mutation status could contribute to the selection of effective treatment for individual patients. Currently, precision medicine utilizing genetic and genomic data is becoming to play an increasingly
Bethany Smith
Bethany Smith
Department of Medicine, Samuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
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Priyanka Agarwal
Priyanka Agarwal
Department of Medicine, Samuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
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Neil A Bhowmick
Neil A Bhowmick
Department of Medicine, Samuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Greater Los Angeles Veterans Administration, Los Angeles, California, USA
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Greater Los Angeles Veterans Administration, Los Angeles, California, USA
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Introduction Precision medicine refers to leveraging larger scale somatic or genomic data in the informing medical decision-making. Although the principles of precision medicine are extending into proteomics and metabolomics, a vast amount of
Lamis Yehia
Lamis Yehia
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Charis Eng
Charis Eng
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Germline High Risk Cancer Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
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Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Germline High Risk Cancer Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
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serving as a model for precision medicine ( Eng 2000 , Tan et al . 2012 , Mester & Eng 2013 , Tilot et al . 2015 , Ngeow et al . 2017 ). Cowden syndrome (CS; MIM 158350) is an autosomal dominant multi-system disorder characterized by multiple
Fabio R Faucz
Fabio R Faucz
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
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Anelia D Horvath
Anelia D Horvath
Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, United States of America
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Guillaume Assié
Guillaume Assié
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, Paris, France
Endocrine Department, Center for Rare Adrenal Diseases, AP-HP, Hôpital Cochin, Paris, France
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Endocrine Department, Center for Rare Adrenal Diseases, AP-HP, Hôpital Cochin, Paris, France
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Madson Q Almeida
Madson Q Almeida
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
Adrenal Unit, Laboratory of Molecular and Cellular Endocrinology LIM/25, Division of Endocrinology and Metabolism, University of Sao Paulo Medical School, São Paulo, Brasil
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Adrenal Unit, Laboratory of Molecular and Cellular Endocrinology LIM/25, Division of Endocrinology and Metabolism, University of Sao Paulo Medical School, São Paulo, Brasil
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Eva Szarek
Eva Szarek
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
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Sosipatros Boikos
Sosipatros Boikos
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
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Anna Angelousi
Anna Angelousi
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
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Isaac Levy
Isaac Levy
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
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Andrea G Maria
Andrea G Maria
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
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Ajay Chitnis
Ajay Chitnis
Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
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Cristina R Antonescu
Cristina R Antonescu
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Rainer Claus
Rainer Claus
Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany
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Jérôme Bertherat
Jérôme Bertherat
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, Paris, France
Endocrine Department, Center for Rare Adrenal Diseases, AP-HP, Hôpital Cochin, Paris, France
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Endocrine Department, Center for Rare Adrenal Diseases, AP-HP, Hôpital Cochin, Paris, France
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Christoph Plass
Christoph Plass
Division of Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany
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Charis Eng
Charis Eng
Genomic Medicine Institute, Lerner Research Institute, and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
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Constantine A Stratakis
Constantine A Stratakis
Section on Endocrinology & Genetics, Program on Developmental Endocrinology & Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
Human Genetics & Precision Medicine, IMBB, Foundation for Research & Technology Hellas, Heraklion, Crete, Greece
Research Institute, ELPEN, Pikermi, Athens, Greece
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Human Genetics & Precision Medicine, IMBB, Foundation for Research & Technology Hellas, Heraklion, Crete, Greece
Research Institute, ELPEN, Pikermi, Athens, Greece
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, Inc. and Sync, Inc.; he is also the director of Genetics & Precision Medicine, at FORTH ( www.forth.gr ); none of these activities conflict with the contents of this article. F.R.F. holds a patent on the GPR101 gene and/or its function. The other
Xumeng Wang
Xumeng Wang
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Tianxing Ying
Tianxing Ying
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Jimeng Yuan
Jimeng Yuan
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Yue Wang
Yue Wang
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Xingyun Su
Xingyun Su
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Shitu Chen
Shitu Chen
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Yurong Zhao
Yurong Zhao
Institute of Environmental Medicine and Hepatobiliary and Pancreatic Surgery of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China
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Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China
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Yuanyuan Zhao
Yuanyuan Zhao
Institute of Environmental Medicine and Hepatobiliary and Pancreatic Surgery of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China
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Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China
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Jinghao Sheng
Jinghao Sheng
Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China
Institute of Environmental Medicine of Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Institute of Environmental Medicine of Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Lisong Teng
Lisong Teng
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Chi Luo
Chi Luo
Institute of Environmental Medicine and Hepatobiliary and Pancreatic Surgery of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China
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Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China
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Weibin Wang
Weibin Wang
Department of Surgical Oncology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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& Pietzsch J 2007 L-type amino acid transporters LAT1 and LAT4 in cancer: uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo . Journal of Nuclear Medicine 48 2063 – 2071 . ( https://doi.org/10
David Taïeb
David Taïeb
Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France
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Abhishek Jha
Abhishek Jha
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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Giorgio Treglia
Giorgio Treglia
Clinic of Nuclear Medicine and PET/CT Center, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
Health Technology Assessment Unit, General Directorate, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
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Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
Health Technology Assessment Unit, General Directorate, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
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Karel Pacak
Karel Pacak
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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nor ethical. Therefore, adoption of a composite of imaging and/or pathologic findings should be considered a robust alternative ( Hofman & Hicks 2015 ). Theranostics Personalized (precision) medicine has already made its mark and has the
Nely Díaz-Mejía
Nely Díaz-Mejía
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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David García-Illescas
David García-Illescas
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Rafael Morales-Barrera
Rafael Morales-Barrera
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Cristina Suarez
Cristina Suarez
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Jacques Planas
Jacques Planas
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Xavier Maldonado
Xavier Maldonado
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Joan Carles
Joan Carles
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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Joaquin Mateo
Joaquin Mateo
Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
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genomic landscape of lethal prostate cancer allows for reclassifying this disease based on predictive biomarkers for specific drugs, aiming for accelerating the development of precision medicine strategies for advanced prostate cancer. The recent approvals
Sergio Vargas-Salas
Sergio Vargas-Salas
Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile
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José R Martínez
José R Martínez
Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile
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Soledad Urra
Soledad Urra
Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile
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José Miguel Domínguez
José Miguel Domínguez
Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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Natalia Mena
Natalia Mena
GeneproDX, Santiago, Chile
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Thomas Uslar
Thomas Uslar
Department of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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Marcela Lagos
Marcela Lagos
Department of Clinical Laboratories, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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Marcela Henríquez
Marcela Henríquez
Department of Clinical Laboratories, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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Hernán E González
Hernán E González
Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile
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emergence of precision medicine has changed the paradigm of ITC management. The first test released to the market was the Afirma gene expression classifier (Afirma-GEC) ( Alexander et al. 2012 ), followed by ThyGenX/ThyraMIR ( Labourier et al. 2015
Lois M Mulligan
Lois M Mulligan
Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada
Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada
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Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada
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the molecular effects of disease mutations, the mechanisms by which they cause cellular dysfunctions and the implications of these at the organismal level underlie the great strength of precision medicine to effectively target the patient’s needs and
