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Wouter T Zandee
Wouter T Zandee
Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands
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Kimberly Kamp
Kimberly Kamp
Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands
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Roxanne C van Adrichem
Roxanne C van Adrichem
Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands
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Richard A Feelders
Richard A Feelders
Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands
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Wouter W de Herder
Wouter W de Herder
Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands
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the incidence of peptic ulcer disease ( Hirschowitz et al . 2005 ). It is without question that before all these contemporary options were available, patients with a hypersecreting NET had a worse prognosis, due to the complications of hormone
Kristina Warton
Kristina Warton
Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia
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Kate L Mahon
Kate L Mahon
Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia
Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia
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Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia
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Goli Samimi
Goli Samimi
Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia
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Methylated circulating DNA in cancer prognosis and monitoring Genomics is anticipated to bring major improvements in the treatment of cancer patients. The capacity to quickly and relatively inexpensively sequence tumor DNA on a genome-wide scale
Mojun Zhu
Mojun Zhu
Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
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Karl R Sorenson
Karl R Sorenson
Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
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Rebecca Liu
Rebecca Liu
Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
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Bonnie E Gould Rothberg
Bonnie E Gould Rothberg
Smilow Cancer Hospital, Yale-New Haven Health System, New Haven, Connecticut, USA
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Thorvardur R Halfdanarson
Thorvardur R Halfdanarson
Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
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, Kunz et al. 2018 , Halfdanarson et al. 2020 ). Diagnosis and prognosis of PNETs depend on both cell morphology (degree of differentiation) and tumor grade as measured by the rate of cell proliferation (Ki-67 index and/or mitotic rate). This field
Xianhui Ruan
Xianhui Ruan
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Jiaoyu Yi
Jiaoyu Yi
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Linfei Hu
Linfei Hu
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Jingtai Zhi
Jingtai Zhi
Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital, Nankai District of Tianjin, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Clinical Discipline of Tianjin (Otolaryngology), Otolaryngology Clinical Quality Control Centre, Tianjin, People’s Republic of China
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Yu Zeng
Yu Zeng
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Xiukun Hou
Xiukun Hou
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Jianfeng Huang
Jianfeng Huang
Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA
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Pengfei Gu
Pengfei Gu
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Weijing Hao
Weijing Hao
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Ming Gao
Ming Gao
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, Tianjin, People’s Republic of China
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Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, Tianjin, People’s Republic of China
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Yi Pan
Yi Pan
Department of Pathology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China
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Songfeng Wei
Songfeng Wei
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Xiangqian Zheng
Xiangqian Zheng
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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, including melanoma, breast cancer, colorectal cancer, ovarian cancer, prostate cancer, glioma, and non-small cell lung cancer, have found an association between tsMHC-II and a favorable prognosis ( Yazawa et al. 1999 , Bustin et al. 2001 , Soos et al
Massimo Milione
Massimo Milione
1st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Patrick Maisonneuve
Patrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology (IEO), Milan, Italy
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Alessio Pellegrinelli
Alessio Pellegrinelli
1st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Federica Grillo
Federica Grillo
Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova and Policlinico San Martino, Genova, Italy
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Luca Albarello
Luca Albarello
Pathology Unit, IRCCS San Raffaele Scientifica Institute, Milan, Italy
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Paola Spaggiari
Paola Spaggiari
Cancer Center Humanitas, Milan, Italy
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Alessandro Vanoli
Alessandro Vanoli
Fondazione IRCCS Policlinico San Matteo and Department of Molecular Medicine, University of Pavia, Pavia, Italy
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Giovanna Tagliabue
Giovanna Tagliabue
Lombardy Cancer Registry, Varese Province Cancer Registry Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Eleonora Pisa
Eleonora Pisa
Division of Pathology, European Institute of Oncology (IEO), Milan, Italy
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Luca Messerini
Luca Messerini
Diagnostic and Molecular Pathology, Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy
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Giovanni Centonze
Giovanni Centonze
Department of Experimental Oncology and Molecular Medicine, Unit of Tumor Genomics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Clinical Research Lab (CRAB), Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Clinical Research Lab (CRAB), Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Frediano Inzani
Frediano Inzani
Anatomic Pathology Unit, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy
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Aldo Scarpa
Aldo Scarpa
ARC-Net Research Centre and Department of Diagnostics and Public Health-Section of Pathology, University and Hospital Trust of Verona, Verona, Italy
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Mauro Papotti
Mauro Papotti
Department of Oncology, University of Turin, Turin, Italy
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Marco Volante
Marco Volante
Department of Oncology, University of Turin, Turin, Italy
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Fausto Sessa
Fausto Sessa
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Nicola Fazio
Nicola Fazio
Gastrointestinal Medical Oncology and Neuroendocrine Tumors Unit, European Institute of Oncology (IEO), Milan, Italy
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Giancarlo Pruneri
Giancarlo Pruneri
1st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
University of Milan, School of Medicine, Milan, Italy
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University of Milan, School of Medicine, Milan, Italy
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Guido Rindi
Guido Rindi
Institute of Anatomic Pathology, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario A. Gemelli, Rome, Italy
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Enrico Solcia
Enrico Solcia
Fondazione IRCCS Policlinico San Matteo and Department of Molecular Medicine, University of Pavia, Pavia, Italy
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Stefano La Rosa
Stefano La Rosa
Service of Clinical Pathology, Lausanne University Hospital, Institute of Pathology, Lausanne, Switzerland
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Carlo Capella
Carlo Capella
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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demonstrates that the prognosis of MANECs from digestive system is driven mostly by the NEC component with special reference to its Ki67 proliferative index. Ki67 index of the NEC component has proven to be far superior to MC or, indeed, to any other prognostic
Yuanliang Yan
Yuanliang Yan
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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Qiuju Liang
Qiuju Liang
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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Yuanhong Liu
Yuanhong Liu
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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Shangjun Zhou
Shangjun Zhou
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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Zhijie Xu
Zhijie Xu
Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
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, COL12A1 was found to influence the therapeutic responses toward durvalumab, an anti-PD-L1 inhibitory ( Bachelot et al. 2021 ) and predict poor prognosis in BC. Moreover, COL12A1 was highly expressed in BC tissues, estrogen receptor (ER
Yihao Chen
Yihao Chen
Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China
Department of Urology, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
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Department of Urology, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
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Jiahong Chen
Jiahong Chen
Department of Urology, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
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Yongcheng Shi
Yongcheng Shi
Department of Urology, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
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Xiaohui Ling
Xiaohui Ling
Reproductive Medicine Center, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
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Shumin Fang
Shumin Fang
Science Research Center, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
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Chuanfan Zhong
Chuanfan Zhong
Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China
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Fengping Liu
Fengping Liu
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China
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Weide Zhong
Weide Zhong
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China
Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China
Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou Institute of Urology, Guangzhou, Guangdong
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Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China
Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou Institute of Urology, Guangzhou, Guangdong
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Xuecheng Bi
Xuecheng Bi
Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
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Zhong Dong
Zhong Dong
Department of Urology, Huizhou Municipal Central Hospital, Huizhou, Guangdong, China
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Jianming Lu
Jianming Lu
Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China
Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China
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Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China
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rate is a mere 35%. Despite the low incidence of ACC, the prognosis for most patients remains poor, with many experiencing local recurrence and metastasis even after undergoing radical surgery. Furthermore, besides radical surgery, few treatment options
Maria Chiara Zatelli
Maria Chiara Zatelli
Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy
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Erika Maria Grossrubatscher
Erika Maria Grossrubatscher
Endocrine Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
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Elia Guadagno
Elia Guadagno
Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy
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Concetta Sciammarella
Concetta Sciammarella
IOS & COLEMAN Srl, Naples, Italy
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Antongiulio Faggiano
Antongiulio Faggiano
Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura Dei Tumori ‘Fondazione G. Pascale’ – IRCCS, Naples, Italy
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Annamaria Colao
Annamaria Colao
IOS & COLEMAN Srl, Naples, Italy
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Introduction Neuroendocrine neoplasms (NENs) are heterogeneous tumors with widely different behavior and prognosis, that to date had been related mainly to the grade of neuroendocrine differentiation as well as the proliferative attitude of
Yuanliang Li
Yuanliang Li
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
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Yiying Guo
Yiying Guo
Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Zixuan Cheng
Zixuan Cheng
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
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Chao Tian
Chao Tian
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
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Yingying Chen
Yingying Chen
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
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Ruao Chen
Ruao Chen
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
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Fuhuan Yu
Fuhuan Yu
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
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Yanfen Shi
Yanfen Shi
Department of Pathology, China-Japan Friendship Hospital, Beijing, China
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Fei Su
Fei Su
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China
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Shuhua Zhao
Shuhua Zhao
Department of Biological Information Research, HaploX Biotechnology Co., Ltd, Shenzhen, Guangdong, China
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Zhizheng Wang
Zhizheng Wang
Academic Department, HaploX Biotechnology, Co., Ltd, Shenzhen, Guangdong, China
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Jie Luo
Jie Luo
Department of Pathology, China-Japan Friendship Hospital, Beijing, China
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Huangying Tan
Huangying Tan
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China
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Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China
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Chinese R-NETs. We investigated frequently altered signaling pathways, variations potentially affecting the prognosis, potentially targetable gene alterations (PTGAs), and gene alterations potentially influencing the efficacy of immune checkpoint blockade
Cristina Gurizzan
Cristina Gurizzan
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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Manuel Zamparini
Manuel Zamparini
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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Marco Volante
Marco Volante
Department of Oncology, University of Turin, AOU San Luigi, Orbassano, Turin, Italy
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Valeria Tovazzi
Valeria Tovazzi
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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Vito Amoroso
Vito Amoroso
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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Francesca Consoli
Francesca Consoli
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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Fausto Petrelli
Fausto Petrelli
ASST Bergamo Ovest, Ospedale Treviglio, Treviglio, Italy
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Salvatore Grisanti
Salvatore Grisanti
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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Paolo Bossi
Paolo Bossi
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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Alfredo Berruti
Alfredo Berruti
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy
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patient prognosis is frequently favorable; however, aggressive cases have also been described, making the identification of prognostic parameters important. This study was undertaken to systematically review all ITC cases described in the literature
