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Takako Araki, Ning-Ai Liu, Yukiko Tone, Daniel Cuevas-Ramos, Roy Heltsley, Masahide Tone, and Shlomo Melmed

). Subcellular mechanisms for ectopic Cushing’s syndrome are poorly defined. ACTH produced by post-translational cleavage from the proopiomelanocortin (POMC) precursor is abundantly expressed in pituitary corticotroph cells and in the hypothalamus ( Stevens

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K E Lines, P Filippakopoulos, M Stevenson, S Müller, H E Lockstone, B Wright, S Knapp, D Buck, C Bountra, and R V Thakker

). Octreotide did not significantly alter the proliferation of AtT20 cells, either alone or in combination with JQ1 treatment (Supplementary Fig. 5). JQ1 treatment reduces pro-opiomelanocortin (POMC) expression and alters ACTH secretion of AtT20 cells

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Luis G Perez-Rivas, Andrea Oßwald, Thomas Knösel, Kristin Lucia, Christian Schaaf, Michael Hristov, Julia Fazel, Thomas Kirchner, Felix Beuschlein, Martin Reincke, and Marily Theodoropoulou

precursor proopiomelanocortin (POMC, unprocessed or partially cleaved) or, less frequently, corticotropin-releasing hormone (CRH). Bronchial carcinoids and small cell carcinomas of the lung (SCLC) are the most frequent causes of EAS ( Alexandraki & Grossman

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Anne White

making monoclonal antibodies to ACTH and its precursor pro-opiomelanocortin (POMC). Initially, we developed monoclonal antibodies to both the N- and C-terminal regions of ACTH, which enabled us to develop a two-site assay that was more specific and a

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Giampaolo Trivellin, Ricardo R Correa, Maria Batsis, Fabio R Faucz, Prashant Chittiboina, Ivana Bjelobaba, Darwin O Larco, Martha Quezado, Adrian F Daly, Stanko S Stojilkovic, T John Wu, Albert Beckers, Maya B Lodish, and Constantine A Stratakis

hypothalamic neurons expressing proopiomelanocortin ( POMC ), the precursor of ACTH ( Nilaweera et al . 2007 , Bagnol 2010 ). Moreover, GPR101 was shown to mediate the phosphorylation of epidermal growth factor receptor ( EGFR ), leading to enhanced cellular

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Nabahet Ameur, Ludovic Lacroix, Sophie Roucan, Véronique Roux, Sophie Broutin, Monique Talbot, Corinne Dupuy, Bernard Caillou, Martin Schlumberger, and Jean-Michel Bidart

collagen type 1 α-1 and -2, Cadherin 11 ( CDH11 ), the fibroblast activation protein FAP, and FBLN1 , an extracellular matrix protein. The POMC gene, encoding proopiomelanocortin, a pro ACTH–endorphin molecule synthesized by the anterior pituitary gland

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G Schlossmacher, E Platt, A Davies, S Meredith, and A White

neuropeptides including the adrenocorticotropic hormone (ACTH) precursor, pro-opiomelanocortin (POMC; Stovold et al . 2011 ). In certain situations, this can give rise to the ectopic ACTH syndrome ( Stewart et al . 1994 ). However, evidence suggests that SCLC

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Tullio Florio, Federica Barbieri, Renato Spaziante, Gianluigi Zona, Leo J Hofland, Peter M van Koetsveld, Richard A Feelders, Günter K Stalla, Marily Theodoropoulou, Michael D Culler, Jesse Dong, John E Taylor, Jacques-Pierre Moreau, Alexandru Saveanu, Ginette Gunz, Henry Dufour, and Philippe Jaquet

assessed. The second aliquot was used for quantification of FSH, LH, α-subunit, GH, and pro-opiomelanocortin (POMC) mRNA expression, in order to characterize the different NFPAs and to screen for potential contamination of the tumor cells by adjacent

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Ines Donangelo, Song-Guang Ren, Tamar Eigler, Clive Svendsen, and Shlomo Melmed

, Top panel) qRT-PCR results showing that Sca1 + pituitary tumor cells have lower mRNA expression levels of pro-opiomelanocortin ( Pomc ), Gh , and prolactin ( Prl ), but not glycoprotein alpha-subunit ( αGsu )) compared with Sca1 − pituitary tumor

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Maria P Yavropoulou, Marina Tsoli, Konstantinos Barkas, Gregory Kaltsas, and Ashley Grossman

, guanine–adenine–thymine–adenine binding protein 2; Pit-1, pituitary transcription factor 1; T-pit, T-box family member TBX19; POMC, precursor polypeptide pro-opiomelanocortin; ACTH, adrenocorticotropic hormone; ERα, estrogen receptor-αlpha; FSH, follicle