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Isabelle Laverdière, Christine Flageole, Étienne Audet-Walsh, Patrick Caron, Yves Fradet, Louis Lacombe, Éric Lévesque and Chantal Guillemette

) genes UGT2B17 and UGT2B28 involved in the catabolism of androgenic sex steroids have been recognized as prognostic markers for localized PCa after radical prostatectomy (RP) ( Nadeau et al . 2011 ). The UGT-mediated metabolic pathways, governed by

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Sciarra Alessandro, Gentile Vincenzo, Autran Gomez Ana Maria, Salciccia Stefano, Gentilucci Alessandro, Monti Salvatore, Toscano Vincenzo and Di Silverio Franco

Introduction Approximately, 40% of prostate cancer patients who choose definitive therapy will undergo radical prostatectomy (RRP; Jemal et al. 2005 , Simmons et al. 2007 ).While overall cancer control rates are high for

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Ken Chow, Stefano Mangiola, Jaideep Vazirani, Justin S Peters, Anthony J Costello, Christopher M Hovens and Niall M Corcoran

and survival. In this study, we aimed to assess the relative importance of these two mechanisms on driving poorer outcomes in obese patients. Materials and methods Patient selection Consecutive patients undergoing prostatectomy for

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Veronica R Placencio-Hickok, Anisha Madhav, Sungjin Kim, Frank Duong, Bryan Angara, Zhenqiu Liu and Neil A Bhowmick

radical prostatectomy, a reliable prognostic biomarker to identify patient recurrence status at the time of surgical intervention would be invaluable in supporting early adjuvant therapy. Approximately 35% of patients will develop biochemical recurrence

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Won-Mook Choi, Jeong-Hoon Lee, Jung-Hwan Yoon, Cheol Kwak, Young Ju Lee, Young Youn Cho, Yun Bin Lee, Su Jong Yu, Yoon Jun Kim, Hyeon Hoe Kim, Hyo-Cheol Kim, Sung Yong Cho, Seung Bae Lee, Hyeon Jeong, Chung Yong Kim and Hyo-Suk Lee

association between obesity and prostate cancer showed conflicting results, a recent meta-analysis has concluded that obesity is associated with increased risk of prostate cancer-specific mortality and biochemical recurrence (BCR) after radical prostatectomy

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Filipa Quintela Vieira, Pedro Costa-Pinheiro, João Ramalho-Carvalho, Andreia Pereira, Francisco Duarte Menezes, Luís Antunes, Isa Carneiro, Jorge Oliveira, Rui Henrique and Carmen Jerónimo

submitted to radical prostatectomy, and further test their clinical usefulness for the prediction of disease progression. Materials and methods Patients and tissue collection Primary tumors from 160 patients with clinically localized prostate adenocarcinoma

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Stefano Mangiola, Ryan Stuchbery, Geoff Macintyre, Michael J Clarkson, Justin S Peters, Anthony J Costello, Christopher M Hovens and Niall M Corcoran

RNA sequencing on periprostatic adipose tissue obtained at the time of prostatectomy, to determine if there existed a transcriptional signature that would allow differentiation between groups of patients at high or low risk of progression. We found

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Yu Wang, Andres Roma, Rosalie Nolley, Fadi Abdul-Karim, Donna M Peehl and Charis Eng

stage T2b–T2c tumors, PSA between 10 and 20 ng/ml, or Gleason score 7 ( D'Amico et al . 1998 b ). After radical prostatectomy (RP), 65–80% of patients with IRPC had 5-year relapse-free survival (RFS) ( D'Amico et al . 1998 b , c , d , Meng et al

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Tianzhu Zang, Mary-Ellen Taplin, Daniel Tamae, Wanling Xie, Clementina Mesaros, Zhenwei Zhang, Glenn Bubley, Bruce Montgomery, Steven P Balk, Elahe A Mostaghel, Ian A Blair and Trevor M Penning

. Neoadjuvant androgen deprivation therapy (NADT) refers to ADT before patients undertake radical prostatectomy or radiation therapy ( Kent & Hussain 2003 ). The aim of this approach is to downstage the malignant tumor, facilitate the complete surgical removal

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Simone de Brot, Atara Ntekim, Ryan Cardenas, Victoria James, Cinzia Allegrucci, David M Heery, David O Bates, Niels Ødum, Jenny L Persson and Nigel P Mongan

not require any therapy ( Draisma et al . 2009 , Cuzick et al . 2014 , Tombal et al . 2014 , Weiner et al . 2015 ). Therefore, most men with clinically localized PCa undergo radical prostatectomy or radiotherapy with curative intent ( Boorjian