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Aparna Lakshmanan, Anna Wojcicka, Marta Kotlarek, Xiaoli Zhang, Krystian Jazdzewski, and Sissy M Jhiang

Introduction Na + /I − symporter (NIS)-mediated radioiodide uptake (RAIU) in thyroid cells allows for targeted treatment of thyroid cancer. Many patients with advanced thyroid cancer do not benefit from radioiodine therapy due to reduced

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Christina Schug, Sarah Urnauer, Carsten Jaeckel, Kathrin A Schmohl, Mariella Tutter, Katja Steiger, Nathalie Schwenk, Markus Schwaiger, Ernst Wagner, Peter J Nelson, and Christine Spitzweg

. The resulting clones were isolated and analyzed for NIS-mediated radioiodide uptake activity using an iodide uptake assay (see below). Among ~40 screened colonies, the stably transfected cell clone with the highest levels of iodide accumulation was

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T Kogai, K Taki, and G A Brent

al. 1997 , Saito et al. 1997 , Pekary & Hershman 1998 ). The influence of TSH on the stimulation of radioiodide uptake in metastatic thyroid cancer has been recognized, since radioiodine was first used in the 1950s. TSH stimulation is achieved by

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Douangsone D Vadysirisack, Anjli Venkateswaran, Zhaoxia Zhang, and Sissy M Jhiang

metastatic thyroid cancers. However, NIS expression, as well as NIS-mediated radioiodide uptake (RAIU) activity, is lost in some patients with advanced thyroid cancers, such that these patients cannot benefit from radioiodine imaging and therapy ( Arturi

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Garcilaso Riesco-Eizaguirre, Pilar Santisteban, and Antonio De la Vieja

cancer models ( Bollag et al. 2010 ). Therefore, potent inhibition of ERK signaling seems to be required to adequately induce iodide uptake, rendering tumor cells susceptible to a therapeutic dose of radioiodide. An allosteric MEK inhibitor (CKI) that

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W Imruetaicharoenchoke, A Fletcher, W Lu, R J Watkins, B Modasia, V L Poole, H R Nieto, R J Thompson, K Boelaert, M L Read, V E Smith, and C J McCabe

et al . 2007 ). PBF also binds to the sodium iodide symporter (NIS) and monocarboxylate transporter 8 (MCT8), modulating their subcellular localisation, and regulating radioiodide uptake and thyroid hormone efflux, respectively ( Smith et al . 2009

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Yu-Yu Liu, Xiaoli Zhang, Matthew D Ringel, and Sissy M Jhiang

parental thyroid cells, albeit with different magnitude and temporal dynamics ( Garcia & Santisteban 2002 , Knauf et al . 2003 , Vadysirisack et al . 2007 b ). NIS-mediated radioiodide uptake (RAIU) was transiently decreased at 4 h, but increased at 24

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Kathleen A Luckett, Jennifer R Cracchiolo, Gnana P Krishnamoorthy, Luis Javier Leandro-Garcia, James Nagarajah, Mahesh Saqcena, Rona Lester, Soo Y Im, Zhen Zhao, Scott W Lowe, Elisa de Stanchina, Eric J Sherman, Alan L Ho, Steven D Leach, Jeffrey A Knauf, and James A Fagin

tyrosine kinases ( Fagin & Wells 2016 ). There is an inverse correlation between the MAPK signaling flux of PTCs, as measured by its transcriptional output, and the expression of genes required for iodine uptake and thyroid hormone biosynthesis ( Cancer

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Camille Buffet, Johanna Wassermann, Fabio Hecht, Laurence Leenhardt, Corinne Dupuy, Lionel Groussin, and Charlotte Lussey-Lepoutre

Kobayashi T 2004 Histone deacetylase inhibitors restore radioiodide uptake and retention in poorly differentiated and anaplastic thyroid cancer cells by expression of the sodium/iodide symporter thyroperoxidase and thyroglobulin . Endocrinology 145

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Sissy M Jhiang and Jennifer A Sipos

precursor cells are committed to the differentiated gastric mucosa. NIS expression in breast tissues NIS expression and radioiodide uptake in breast tissues are at the highest levels during active lactation ( Cho et al. 2000 , Tazebay et al